Gene Review:
CCR8 - chemokine (C-C motif) receptor 8
Homo sapiens
Synonyms:
C-C CKR-8, C-C chemokine receptor type 8, CC chemokine receptor CHEMR1, CC-CKR-8, CCR-8, ...
Panina-Bordignon,
Papi,
Mariani,
Di Lucia,
Casoni,
Bellettato,
Buonsanti,
Miotto,
Mapp,
Villa,
Arrigoni,
Fabbri,
Sinigaglia,
Douglas,
Thirkill,
Sideris,
Rabieh,
Trollinger,
Nuccitelli,
Segerer,
Cui,
Eitner,
Goodpaster,
Hudkins,
Mack,
Cartron,
Colin,
Schlondorff,
Alpers,
Howard,
Dong,
Shirakawa,
Oppenheim,
Jenkins,
Guan,
Dai,
Li,
Lightburn,
Huang,
Freeze,
Burdi,
Jacutin-Porte,
Bennett,
Chen,
Minor,
Ghosh,
Blackburn,
Gigstad,
Jones,
Kolbeck,
Yin,
Smith,
Cardillo,
Ocain,
Harriman,
Horuk,
Hesselgesser,
Zhou,
Faulds,
Halks-Miller,
Harvey,
Taub,
Samson,
Parmentier,
Rucker,
Doranz,
Doms,
- Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. Goya, I., Gutiérrez, J., Varona, R., Kremer, L., Zaballos, A., Márquez, G. J. Immunol. (1998)
- The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. Horuk, R., Hesselgesser, J., Zhou, Y., Faulds, D., Halks-Miller, M., Harvey, S., Taub, D., Samson, M., Parmentier, M., Rucker, J., Doranz, B.J., Doms, R.W. J. Biol. Chem. (1998)
- Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses. Rucker, J., Edinger, A.L., Sharron, M., Samson, M., Lee, B., Berson, J.F., Yi, Y., Margulies, B., Collman, R.G., Doranz, B.J., Parmentier, M., Doms, R.W. J. Virol. (1997)
- The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. Haque, N.S., Fallon, J.T., Taubman, M.B., Harpel, P.C. Blood (2001)
- A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. Ly, H., Xu, L., Rivera, M.A., Parslow, T.G., Blackburn, E.H. Genes Dev. (2003)
- A skin-selective homing mechanism for human immune surveillance T cells. Schaerli, P., Ebert, L., Willimann, K., Blaser, A., Roos, R.S., Loetscher, P., Moser, B. J. Exp. Med. (2004)
- Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. Qu, C., Edwards, E.W., Tacke, F., Angeli, V., Llodrá, J., Sanchez-Schmitz, G., Garin, A., Haque, N.S., Peters, W., van Rooijen, N., Sanchez-Torres, C., Bromberg, J., Charo, I.F., Jung, S., Lira, S.A., Randolph, G.J. J. Exp. Med. (2004)
- The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. Spinetti, G., Bernardini, G., Camarda, G., Mangoni, A., Santoni, A., Capogrossi, M.C., Napolitano, M. J. Leukoc. Biol. (2003)
- Effects of albumin supplementation on microvascular permeability in septic patients. Margarson, M.P., Soni, N.C. J. Appl. Physiol. (2002)
- Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. Tiffany, H.L., Lautens, L.L., Gao, J.L., Pease, J., Locati, M., Combadiere, C., Modi, W., Bonner, T.I., Murphy, P.M. J. Exp. Med. (1997)
- Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. Iellem, A., Mariani, M., Lang, R., Recalde, H., Panina-Bordignon, P., Sinigaglia, F., D'Ambrosio, D. J. Exp. Med. (2001)
- LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Howard, O.M., Dong, H.F., Shirakawa, A.K., Oppenheim, J.J. Blood (2000)
- Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity. Sebastiani, S., Allavena, P., Albanesi, C., Nasorri, F., Bianchi, G., Traidl, C., Sozzani, S., Girolomoni, G., Cavani, A. J. Immunol. (2001)
- The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. Panina-Bordignon, P., Papi, A., Mariani, M., Di Lucia, P., Casoni, G., Bellettato, C., Buonsanti, C., Miotto, D., Mapp, C., Villa, A., Arrigoni, G., Fabbri, L.M., Sinigaglia, F. J. Clin. Invest. (2001)
- Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Haque, N.S., Fallon, J.T., Pan, J.J., Taubman, M.B., Harpel, P.C. Blood (2004)
- Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. Inngjerdingen, M., Damaj, B., Maghazachi, A.A. J. Immunol. (2000)
- HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. Dairaghi, D.J., Fan, R.A., McMaster, B.E., Hanley, M.R., Schall, T.J. J. Biol. Chem. (1999)
- Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309. Colantonio, L., Iellem, A., Sinigaglia, F., D'Ambrosio, D. Eur. J. Immunol. (2002)
- Structure/Function Relationships of CCR8 Agonists and Antagonists: AMINO-TERMINAL EXTENSION OF CCL1 BY A SINGLE AMINO ACID GENERATES A PARTIAL AGONIST. Fox, J.M., Najarro, P., Smith, G.L., Struyf, S., Proost, P., Pease, J.E. J. Biol. Chem. (2006)
- Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8. Jenkins, T.J., Guan, B., Dai, M., Li, G., Lightburn, T.E., Huang, S., Freeze, B.S., Burdi, D.F., Jacutin-Porte, S., Bennett, R., Chen, W., Minor, C., Ghosh, S., Blackburn, C., Gigstad, K.M., Jones, M., Kolbeck, R., Yin, W., Smith, S., Cardillo, D., Ocain, T.D., Harriman, G.C. J. Med. Chem. (2007)
- Use of alternate coreceptors on primary cells by two HIV-1 isolates. Cilliers, T., Willey, S., Sullivan, W.M., Patience, T., Pugach, P., Coetzer, M., Papathanasopoulos, M., Moore, J.P., Trkola, A., Clapham, P., Morris, L. Virology (2005)
- Changes in and discrepancies between cell tropisms and coreceptor uses of human immunodeficiency virus type 1 induced by single point mutations at the V3 tip of the env protein. Shimizu, N., Haraguchi, Y., Takeuchi, Y., Soda, Y., Kanbe, K., Hoshino, H. Virology (1999)
- Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4. Banwell, M.E., Robinson, D.S., Lloyd, C.M. J. Allergy Clin. Immunol. (2003)
- Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. Bochner, B.S., Hudson, S.A., Xiao, H.Q., Liu, M.C. J. Allergy Clin. Immunol. (2003)
- Chemokine receptor expression by human syncytiotrophoblast. Douglas, G.C., Thirkill, T.L., Sideris, V., Rabieh, M., Trollinger, D., Nuccitelli, R. J. Reprod. Immunol. (2001)
- Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. Napolitano, M., Zingoni, A., Bernardini, G., Spinetti, G., Nista, A., Storlazzi, C.T., Rocchi, M., Santoni, A. J. Immunol. (1996)
- Identification of CCR8, the receptor for the human CC chemokine I-309. Roos, R.S., Loetscher, M., Legler, D.F., Clark-Lewis, I., Baggiolini, M., Moser, B. J. Biol. Chem. (1997)
- Expression of chemokines and chemokine receptors during human renal transplant rejection. Segerer, S., Cui, Y., Eitner, F., Goodpaster, T., Hudkins, K.L., Mack, M., Cartron, J.P., Colin, Y., Schlondorff, D., Alpers, C.E. Am. J. Kidney Dis. (2001)