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Gene Review

Crhbp  -  corticotropin releasing hormone binding...

Mus musculus

Synonyms: CRF-BP, CRF-binding protein, CRH-BP, Corticotropin-releasing factor-binding protein, Corticotropin-releasing hormone-binding protein
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Disease relevance of Crhbp


High impact information on Crhbp


Biological context of Crhbp


Anatomical context of Crhbp

  • Overexpression of CRF-BP in vivo accelerated the loss of tail muscle cells during spontaneous metamorphosis [7].
  • These changes are consistent with the hypothesis that CRH-BP plays an important in vivo modulatory role by regulating levels of "free" CRH and other CRH-like peptides in the pituitary and central nervous system [8].

Associations of Crhbp with chemical compounds


Physical interactions of Crhbp

  • CRH-binding protein (CRH-BP) binds CRH with high affinity and inhibits CRH-mediated ACTH release from anterior pituitary corticotrope-like cells in vitro [9].

Regulatory relationships of Crhbp

  • To investigate the functional significance of gonadotrope CRH-BP, we examined the molecular mechanisms underlying GnRH-regulated CRH-BP expression in alphaT3-1 gonadotrope-like cells [9].

Other interactions of Crhbp

  • These results provide evidence of the first specific roles for CRF-R2 and CRF-BP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for both drugs of abuse and stress [2].
  • In the pituitary, CRH-binding protein (CRH-BP) neutralizes the ACTH-releasing activity of CRH [4].
  • Similarly, both CRH and urocortin bind to the CRH-binding protein (CRH-BP) [8].

Analytical, diagnostic and therapeutic context of Crhbp

  • CRH-BP is endogenously expressed in alphaT3-1 cells, and quantitative real-time RT-PCR and ribonuclease protection assays demonstrate that GnRH induces a 3.7-fold increase in CRH-BP mRNA levels [9].
  • To assess directly the CRH-BP function, we created a mouse model of CRH-BP deficiency by gene targeting [1].
  • Ovariectomy reduces pituitary CRH-BP mRNA levels to 11% of sham-ovariectomy control levels, and estradiol benzoate treatment restores CRH-BP mRNA to control levels [4].
  • While in vitro and in vivo studies have characterized the biochemical properties and regulation of the CRH-BP, animal models of altered CRH-BP expression can provide additional information on the in vivo role of this important modulatory protein [8].


  1. Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice. Karolyi, I.J., Burrows, H.L., Ramesh, T.M., Nakajima, M., Lesh, J.S., Seong, E., Camper, S.A., Seasholtz, A.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Ungless, M.A., Singh, V., Crowder, T.L., Yaka, R., Ron, D., Bonci, A. Neuron (2003) [Pubmed]
  3. Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice. Burrows, H.L., Nakajima, M., Lesh, J.S., Goosens, K.A., Samuelson, L.C., Inui, A., Camper, S.A., Seasholtz, A.F. J. Clin. Invest. (1998) [Pubmed]
  4. Sexually dimorphic expression of corticotropin-releasing hormone-binding protein in the mouse pituitary. Speert, D.B., MCClennen, S.J., Seasholtz, A.F. Endocrinology (2002) [Pubmed]
  5. Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP). Behan, D.P., Potter, E., Lewis, K.A., Jenkins, N.A., Copeland, N., Lowry, P.J., Vale, W.W. Genomics (1993) [Pubmed]
  6. Biochemical characterization and expression analysis of the Xenopus laevis corticotropin-releasing hormone binding protein. Valverde, R.A., Seasholtz, A.F., Cortright, D.N., Denver, R.J. Mol. Cell. Endocrinol. (2001) [Pubmed]
  7. Corticotropin-releasing factor is cytoprotective in Xenopus tadpole tail: coordination of ligand, receptor, and binding protein in tail muscle cell survival. Boorse, G.C., Kholdani, C.A., Seasholtz, A.F., Denver, R.J. Endocrinology (2006) [Pubmed]
  8. Mouse models of altered CRH-binding protein expression. Seasholtz, A.F., Burrows, H.L., Karolyi, I.J., Camper, S.A. Peptides (2001) [Pubmed]
  9. Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alphaT3-1 cells. Westphal, N.J., Seasholtz, A.F. Mol. Endocrinol. (2005) [Pubmed]
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