Gene Review:
Crhr2 - corticotropin releasing hormone receptor 2
Mus musculus
Synonyms:
CRF 2 receptor, CRF-R-2, CRF-R2, CRF-RB, CRFR-2, ...
Tsatsanis,
Androulidaki,
Alissafi,
Charalampopoulos,
Dermitzaki,
Roger,
Gravanis,
Margioris,
Stiedl,
Meyer,
Kishimoto,
Rosenfeld,
Spiess,
Pournajafi Nazarloo,
Tanaka,
Dorobantu,
Hashimoto,
Korosi,
Veening,
Kozicz,
Henckens,
Dederen,
Groenink,
van der Gugten,
Olivier,
Roubos,
Tsatsanis,
Androulidaki,
Dermitzaki,
Charalampopoulos,
Spiess,
Gravanis,
Margioris,
- Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Kishimoto, T., Radulovic, J., Radulovic, M., Lin, C.R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M.G., Spiess, J. Nat. Genet. (2000)
- Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Brar, B.K., Jonassen, A.K., Egorina, E.M., Chen, A., Negro, A., Perrin, M.H., Mjøs, O.D., Latchman, D.S., Lee, K.F., Vale, W. Endocrinology (2004)
- Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Brar, B.K., Chen, A., Perrin, M.H., Vale, W. Endocrinology (2004)
- Stress-mediated heart rate dynamics after deletion of the gene encoding corticotropin-releasing factor receptor 2. Stiedl, O., Meyer, M., Kishimoto, T., Rosenfeld, M.G., Spiess, J. Eur. J. Neurosci. (2003)
- Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. Sharpe, A.L., Coste, S.C., Burkhart-Kasch, S., Li, N., Stenzel-Poore, M.P., Phillips, T.J. Alcohol. Clin. Exp. Res. (2005)
- Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior. Risbrough, V.B., Hauger, R.L., Roberts, A.L., Vale, W.W., Geyer, M.A. J. Neurosci. (2004)
- Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Bale, T.L., Contarino, A., Smith, G.W., Chan, R., Gold, L.H., Sawchenko, P.E., Koob, G.F., Vale, W.W., Lee, K.F. Nat. Genet. (2000)
- Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Coste, S.C., Kesterson, R.A., Heldwein, K.A., Stevens, S.L., Heard, A.D., Hollis, J.H., Murray, S.E., Hill, J.K., Pantely, G.A., Hohimer, A.R., Hatton, D.C., Phillips, T.J., Finn, D.A., Low, M.J., Rittenberg, M.B., Stenzel, P., Stenzel-Poore, M.P. Nat. Genet. (2000)
- Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain. Korosi, A., Veening, J.G., Kozicz, T., Henckens, M., Dederen, J., Groenink, L., van der Gugten, J., Olivier, B., Roubos, E.W. Brain Res. (2006)
- Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. Tsatsanis, C., Androulidaki, A., Alissafi, T., Charalampopoulos, I., Dermitzaki, E., Roger, T., Gravanis, A., Margioris, A.N. J. Immunol. (2006)
- Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to chromosome 6. Lesh, J.S., Burrows, H.L., Seasholtz, A.F., Camper, S.A. Mamm. Genome (1997)
- Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis. Carlin, K.M., Vale, W.W., Bale, T.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions. Hinkle, R.T., Donnelly, E., Cody, D.B., Samuelsson, S., Lange, J.S., Bauer, M.B., Tarnopolsky, M., Sheldon, R.J., Coste, S.C., Tobar, E., Stenzel-Poore, M.P., Isfort, R.J. Am. J. Physiol. Endocrinol. Metab. (2003)
- Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Refojo, D., Echenique, C., Müller, M.B., Reul, J.M., Deussing, J.M., Wurst, W., Sillaber, I., Paez-Pereda, M., Holsboer, F., Arzt, E. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Bale, T.L., Giordano, F.J., Hickey, R.P., Huang, Y., Nath, A.K., Peterson, K.L., Vale, W.W., Lee, K.F. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Nie, Z., Schweitzer, P., Roberts, A.J., Madamba, S.G., Moore, S.D., Siggins, G.R. Science (2004)
- Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Ungless, M.A., Singh, V., Crowder, T.L., Yaka, R., Ron, D., Bonci, A. Neuron (2003)
- Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Chen, A., Brar, B., Choi, C.S., Rousso, D., Vaughan, J., Kuperman, Y., Kim, S.N., Donaldson, C., Smith, S.M., Jamieson, P., Li, C., Nagy, T.R., Shulman, G.I., Lee, K.F., Vale, W. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Modulation of corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in the mouse heart. Pournajafi Nazarloo, H., Tanaka, Y., Dorobantu, M., Hashimoto, K. Regul. Pept. (2003)
- Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2. Tsatsanis, C., Androulidaki, A., Dermitzaki, E., Charalampopoulos, I., Spiess, J., Gravanis, A., Margioris, A.N. FEBS Lett. (2005)
- IL-1alpha and TNFalpha down-regulate CRH receptor-2 mRNA expression in the mouse heart. Coste, S.C., Heldwein, K.A., Stevens, S.L., Tobar-Dupres, E., Stenzel-Poore, M.P. Endocrinology (2001)
- Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus. Asakawa, A., Toyoshima, M., Fujimiya, M., Harada, K., Ataka, K., Inoue, K., Koizumi, A. Int. J. Mol. Med. (2007)
- The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Bale, T.L., Hoshijima, M., Gu, Y., Dalton, N., Anderson, K.R., Lee, K.F., Rivier, J., Chien, K.R., Vale, W.W., Peterson, K.L. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Evidence for an axonal localization of the type 2 corticotropin-releasing factor receptor during postnatal development of the mouse cerebellum. Lee, K.H., Bishop, G.A., Tian, J.B., King, J.S. Exp. Neurol. (2004)
- A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity. Chen, A.M., Perrin, M.H., Digruccio, M.R., Vaughan, J.M., Brar, B.K., Arias, C.M., Lewis, K.A., Rivier, J.E., Sawchenko, P.E., Vale, W.W. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1. Stevens, S.L., Shaw, T.E., Dykhuizen, E., Lessov, N.S., Hill, J.K., Wurst, W., Stenzel-Poore, M.P. J. Cereb. Blood Flow Metab. (2003)
- Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation. Müller, M.B., Preil, J., Renner, U., Zimmermann, S., Kresse, A.E., Stalla, G.K., Keck, M.E., Holsboer, F., Wurst, W. Endocrinology (2001)