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Gene Review

Etohd1  -  ethanol decreased 1

Mus musculus

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Disease relevance of Etohd1


High impact information on Etohd1

  • Additionally, ethanol decreased several osteoblastic parameters including osteoblast perimeter and osteoblast culture calcium retention in both il6(+/+) and il6(-/-) mice [5].
  • Ethanol decreased the affinity of the high affinity form of the receptor for isoproterenol but had no effect on the affinity of the low affinity form of the receptor, the proportion of high and low affinity forms of the receptor, the total number of agonist-binding sites, or antagonist binding [6].
  • These results indicate that chronic ingestion of ethanol decreased the fluidity and the ethanol sensitivity of the synaptic membranes [7].
  • In a previous study in ob/ob mice, breath ethanol decreased with a course of non-absorbable antibiotics, suggesting that the ethanol is derived from intestinal bacterial flora [8].
  • 3. Concentration-response analysis of NMDA- and glycine-activated current revealed that ethanol decreased the maximal response to both agonists without affecting their EC50 values [9].

Anatomical context of Etohd1


Associations of Etohd1 with chemical compounds


Other interactions of Etohd1

  • Activation of striatal adenylate cyclase by guanyl-5'-yl-imidodiphosphate occurred after a characteristic lag and inclusion of ethanol decreased the T1/2 of activation by guanyl-5'-yl-imidodiphosphate from 16.9 to 11.2 min [15].
  • In mice 4-12 weeks ingestion of ethanol decreased the concentration of a metallothionein-like protein fraction in the liver but not in the kidneys [16].


  1. Ethanol-induced fetal dysmorphogenesis in the mouse is diminished by high antioxidative capacity of the mother. Wentzel, P., Eriksson, U.J. Toxicol. Sci. (2006) [Pubmed]
  2. Effects of prenatal ethanol and long-chain n-3 fatty acid supplementation on development in mice. 1. Body and brain growth, sensorimotor development, and water T-maze reversal learning. Wainwright, P.E., Ward, G.R., Winfield, D., Huang, Y.S., Mills, D.E., Ward, R.P., McCutcheon, D. Alcohol. Clin. Exp. Res. (1990) [Pubmed]
  3. Effects of environmental enrichment on cortical depth and Morris-maze performance in B6D2F2 mice exposed prenatally to ethanol. Wainwright, P.E., Lévesque, S., Krempulec, L., Bulman-Fleming, B., McCutcheon, D. Neurotoxicology and teratology. (1993) [Pubmed]
  4. Interactions between methaqualone and ethanol in rats and mice during acute and chronic states. Ho, C.C., Ho, A.K. Clin. Exp. Pharmacol. Physiol. (1978) [Pubmed]
  5. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. Dai, J., Lin, D., Zhang, J., Habib, P., Smith, P., Murtha, J., Fu, Z., Yao, Z., Qi, Y., Keller, E.T. J. Clin. Invest. (2000) [Pubmed]
  6. Effect of ethanol on mouse cerebral cortical beta-adrenergic receptors. Valverius, P., Hoffman, P.L., Tabakoff, B. Mol. Pharmacol. (1987) [Pubmed]
  7. Physical properties and lipid composition of brain membranes from ethanol tolerant-dependent mice. Harris, R.A., Baxter, D.M., Mitchell, M.A., Hitzemann, R.J. Mol. Pharmacol. (1984) [Pubmed]
  8. Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Nair, S., Cope, K., Risby, T.H., Diehl, A.M., Terence, R.H. Am. J. Gastroenterol. (2001) [Pubmed]
  9. Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis. Peoples, R.W., White, G., Lovinger, D.M., Weight, F.F. Br. J. Pharmacol. (1997) [Pubmed]
  10. Ethanol-induced expression of c-Fos differentiates the FAST and SLOW selected lines of mice. Demarest, K., Hitzemann, B., Phillips, T., Hitzemann, R. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  11. Exercise reverses ethanol inhibition of neural stem cell proliferation. Crews, F.T., Nixon, K., Wilkie, M.E. Alcohol (2004) [Pubmed]
  12. Effects of barbiturates and ethanol on the physical properties of brain membranes. Harris, R.A., Schroeder, F. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  13. Spinal anesthesia by local anesthetics stimulates the enzyme protein kinase C and induces the expression of an immediate early oncogene, c-Fos. Nivarthi, R.N., Grant, G.J., Turndorf, H., Bansinath, M. Anesth. Analg. (1996) [Pubmed]
  14. The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte. Gyamfi, M.A., Wan, Y.J. Hepatol. Res. (2006) [Pubmed]
  15. Multiple sites of action of ethanol on adenylate cyclase. Rabin, R.A., Molinoff, P.B. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  16. The effect of long-term ethanol treatment on a metal binding protein fraction in liver and kidneys of mice. Hopf, G., Böcker, R., Kusch, G., Estler, C.J. Acta pharmacologica et toxicologica. (1986) [Pubmed]
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