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Gene Review

Slc6a13  -  solute carrier family 6 (neurotransmitter...

Mus musculus

Synonyms: GAT-2, GAT-3, GAT3, Gabt2, Gabt3, ...
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High impact information on Slc6a13


Biological context of Slc6a13


Anatomical context of Slc6a13

  • The developmental distribution of GAT3 suggests involvement in central nervous system (CNS) maturation [7].
  • The expression of GAT3 in the peripheral embryonic tissues was confined to the liver, to a layer of cells under the skin, to the mouse kidney, and to hipoccampal blood vessels only in late developmental stages [7].
  • GAT3 was localized to the meninges in developmental stages where two other GABA transporters, GAT1 and GAT4, were adjacently expressed [7].
  • We have investigated the cellular localization and distribution in the cerebral cortex of adult rats of one GABA transporter (GAT), GAT-3, by immunocytochemistry with affinity-purified polyclonal antibodies directed to its predicted C terminus that react monospecifically with a protein of approximately 70 kDa [2].
  • The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective GABA uptake inhibitor) in modulating GABA levels in the hippocampus and thalamus [8].

Associations of Slc6a13 with chemical compounds

  • The Km for GABA uptake by GAT3 was 18 microM and by GAT4 was 0.8 microM [4].
  • GAT3 also transports beta-alanine and taurine with Km of 28 and 540 microM, respectively [4].
  • Uptake experiments indicated that valproate is not transported by mouse GAT3 in the absence or presence of GABA [3].
  • In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and beta-alanine in a sodium chloride-dependent manner [7].
  • Although a contribution of adrenergic agonistic effects cannot be entirely ruled out, it is proposed that inhibition of GAT-3 (mouse GAT4) is primarily responsible for the anticonvulsant action of these two nipecotic acid derivatives in MES, amygdala kindled rats and in sound-induced seizures in GEP-rats and DBA/2 mice [9].

Other interactions of Slc6a13


  1. Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission. Cohen-Kfir, E., Lee, W., Eskandari, S., Nelson, N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex. Minelli, A., DeBiasi, S., Brecha, N.C., Zuccarello, L.V., Conti, F. J. Neurosci. (1996) [Pubmed]
  3. The anticonvulsant valproate increases the turnover rate of gamma-aminobutyric acid transporters. Whitlow, R.D., Sacher, A., Loo, D.D., Nelson, N., Eskandari, S. J. Biol. Chem. (2003) [Pubmed]
  4. Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. Liu, Q.R., López-Corcuera, B., Mandiyan, S., Nelson, H., Nelson, N. J. Biol. Chem. (1993) [Pubmed]
  5. Polarized expression of GABA transporters in Madin-Darby canine kidney cells and cultured hippocampal neurons. Ahn, J., Mundigl, O., Muth, T.R., Rudnick, G., Caplan, M.J. J. Biol. Chem. (1996) [Pubmed]
  6. Phylogenetic conservation of 4-aminobutyric acid (GABA) transporter isoforms. Cloning and pharmacological characterization of a GABA/beta-alanine transporter from Torpedo. Guimbal, C., Klostermann, A., Kilimann, M.W. Eur. J. Biochem. (1995) [Pubmed]
  7. Developmental expression of the neurotransmitter transporter GAT3. Jursky, F., Nelson, N. J. Neurosci. Res. (1999) [Pubmed]
  8. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Dalby, N.O. Neuropharmacology (2000) [Pubmed]
  9. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Dalby, N.O., Thomsen, C., Fink-Jensen, A., Lundbeck, J., Søkilde, B., Man, C.M., Sørensen, P.O., Meldrum, B. Epilepsy Res. (1997) [Pubmed]
  10. Alteration of the glutamate and GABA transporters in the hippocampus of the Niemann-Pick disease, type C mouse using proteomic analysis. Byun, K., Kim, J., Cho, S.Y., Hutchinson, B., Yang, S.R., Kang, K.S., Cho, M., Hwang, K., Michikawa, M., Jeon, Y.W., Paik, Y.K., Lee, B. Proteomics (2006) [Pubmed]
  11. Developmental expression of GABA transporter-1 and 3 during formation of the GABAergic synapses in the mouse cerebellar cortex. Takayama, C., Inoue, Y. Brain Res. Dev. Brain Res. (2005) [Pubmed]
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