The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cheD  -  chemotaxis protein

Halobacterium sp. NRC-1

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cheD


High impact information on cheD

  • Inspection of the halobacterial genome suggests that BasB and CosB exclusively mediate chemotaxis responses without any additional role in transport, which is in contrast to bacterial binding proteins, which are always part of ABC transport systems [5].
  • Behavioral testing of deletion mutants indicates that halobacterial chemotaxis towards branched-chain amino acids as well as compatible osmolytes of the betaine family requires both a binding and a transducer protein [5].
  • Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium [6].
  • Our results provide the first experimental evidence for the functional coupling between SRI and HtrI and corroborate the proposed model in which HtrI acts as the signal transducer of this archaeal seven-helix photoreceptor in a way analogous to the bacterial chemotaxis transducers [7].
  • The data suggest direct involvement of methylation and demethylation in mechanisms of both chemotaxis and phototaxis and identify adaptation as the sensory process in which those reactions are likely to be involved [8].

Chemical compound and disease context of cheD


Biological context of cheD


Anatomical context of cheD

  • The deduced protein sequence of HtrII predicts a eubacterial chemotaxis transducer type with two hydrophobic membrane-spanning segments connecting sizable domains in the periplasm and cytoplasm [11].
  • Sensory rhodopsin-I (SRI), a phototaxis receptor of archaebacteria, is a retinal-binding protein that exists in the cell membrane intimately associated with a signal-transducing protein (HtrI) homologous to eubacterial chemotaxis receptors [12].

Associations of cheD with chemical compounds


  1. Phosphorylation in halobacterial signal transduction. Rudolph, J., Tolliday, N., Schmitt, C., Schuster, S.C., Oesterhelt, D. EMBO J. (1995) [Pubmed]
  2. Signal processing and flagellar motor switching during phototaxis of Halobacterium salinarum. Nutsch, T., Marwan, W., Oesterhelt, D., Gilles, E.D. Genome Res. (2003) [Pubmed]
  3. Bacillus subtilis chemotaxis: a deviation from the Escherichia coli paradigm. Bischoff, D.S., Ordal, G.W. Mol. Microbiol. (1992) [Pubmed]
  4. Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1. Bonneau, R., Baliga, N.S., Deutsch, E.W., Shannon, P., Hood, L. Genome Biol. (2004) [Pubmed]
  5. A novel mode of sensory transduction in archaea: binding protein-mediated chemotaxis towards osmoprotectants and amino acids. Kokoeva, M.V., Storch, K.F., Klein, C., Oesterhelt, D. EMBO J. (2002) [Pubmed]
  6. Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium. Rudolph, J., Oesterhelt, D. EMBO J. (1995) [Pubmed]
  7. The methyl-accepting transducer protein HtrI is functionally associated with the photoreceptor sensory rhodopsin I in the archaeon Halobacterium salinarium. Ferrando-May, E., Krah, M., Marwan, W., Oesterhelt, D. EMBO J. (1993) [Pubmed]
  8. Methyl-accepting taxis proteins in Halobacterium halobium. Alam, M., Lebert, M., Oesterhelt, D., Hazelbauer, G.L. EMBO J. (1989) [Pubmed]
  9. Photobiology of microorganisms: how photosensors catch a photon to initialize signalling. Hellingwerf, K.J., Hoff, W.D., Crielaard, W. Mol. Microbiol. (1996) [Pubmed]
  10. Primary structure and functional analysis of the soluble transducer protein HtrXI in the archaeon Halobacterium salinarium. Brooun, A., Zhang, W., Alam, M. J. Bacteriol. (1997) [Pubmed]
  11. The primary structures of the Archaeon Halobacterium salinarium blue light receptor sensory rhodopsin II and its transducer, a methyl-accepting protein. Zhang, W., Brooun, A., Mueller, M.M., Alam, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Multicolored protein conformation states in the photocycle of transducer-free sensory rhodopsin-I. Szundi, I., Swartz, T.E., Bogomolni, R.A. Biophys. J. (2001) [Pubmed]
  13. Signal transduction in the archaeon Halobacterium salinarium is processed through three subfamilies of 13 soluble and membrane-bound transducer proteins. Zhang, W., Brooun, A., McCandless, J., Banda, P., Alam, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  14. BasT, a membrane-bound transducer protein for amino acid detection in Halobacterium salinarum. Kokoeva, M.V., Oesterhelt, D. Mol. Microbiol. (2000) [Pubmed]
  15. Aerotaxis in Halobacterium salinarium is methylation-dependent. Lindbeck, J.C., Goulbourne, E.A., Johnson, M.S., Taylor, B.L. Microbiology (Reading, Engl.) (1995) [Pubmed]
WikiGenes - Universities