High impact information on gs

• Like the keratinocytes of glabrous epidermis, most of the colony-forming cells are classified as holoclones or meroclones when analyzed in a clonal assay [1].
• CD24 is also expressed in the outer epithelial sheath of human hair follicles and in glabrous epidermis [2].
• Together with nerve terminals, Merkel cells form slowly adapting cutaneous mechanoreceptors that transduce steady indentation in hairy and glabrous skin [3].
• Epidermal sheets were separated from the skin of the glabrous part of hind limbs and ears of specific pathogen-free (SPF) mice by ethylenediaminetetraacetic acid (EDTA) treatment and stained for adenosine triphosphatase (ATPase) activity [4].
• Unlike BDNF overexpression, NT4 overexpression did not alter the number of Merkel cells in the glabrous skin, but it did enhance the number of myelinated axons in nerves projecting to skin [5].

Biological context of gs

• A previous study of mice overexpressing BDNF in the developing skin (BDNF-OE mice) revealed that these animals exhibited increased hair follicle innervation, Meissner corpuscle size, and Merkel cell number in glabrous skin, although no change in the total number of sensory neurons was observed [5].
• Nerve regeneration was assessed by morphometry of myelinated nerve fibers in the sciatic nerve and of the epidermal innervation density in the glabrous skin of the hindpaws [6].
• A glabrous polar region appears in primary oocytes and a glabrous polar body in secondary oocytes [7].
• Strains with low virulence, Pb265 or the non-virulent, Pb192, showed glabrous/cerebriform morphology and high genetic similarity (98.7%) when compared to the other isolates studied [8].

Anatomical context of gs

• Using morphological studies we now show that Merkel cells develop normally in both hairy and glabrous skin in these animals until 2 weeks old, but are progressively lost thereafter and have almost completely disappeared 2 months after birth [9].
• Using an in vivo mouse preparation, we studied response properties of tibial nerve afferent fibers innervating glabrous skin [10].
• Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study [10].
• The majority of PACAP-positive nerve fibres are, however, located in the glabrous skin of the nipple and the hairy skin adjacent to the nipple forming a subepithelial plexus from which delicate varicose nerve fibres enter the overlying epithelium [11].
• The distribution of ATPase-positive Langerhans' cells was investigated in whole sheets of the glabrous sole-of-foot epidermis of the mouse [12].

Other interactions of gs

• These results suggest that BDNF is the only TrkB ligand involved in the development of Meissner corpuscles in murine glabrous skin, and it probably regulates the development of the sensory neurons that innervate Meissner corpuscles [13].

Analytical, diagnostic and therapeutic context of gs

• The RAPD technique could only discriminate P. brasiliensis isolates according to glabrous/cerebriform or cottony colonies, and also high from low virulence strains [8].

References