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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Merkel Cells

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Disease relevance of Merkel Cells


High impact information on Merkel Cells


Biological context of Merkel Cells


Anatomical context of Merkel Cells


Associations of Merkel Cells with chemical compounds


Gene context of Merkel Cells

  • In 7 of 15 cases containing CK20-positive Merkel cells, CK7 was also seen to stain Merkel cells [24].
  • These results show that NT-3 signaling is not required for the differentiation of Merkel cells, but that it is essential for their postnatal survival [25].
  • At the time of birth, however, Merkel cells are immunoreactive for NT-3, TrkC and p75NTR [25].
  • An awareness of the CK7 reactivity of Toker cells and Merkel cells as well as attention to the cytologic features of the case should avoid this problem [24].
  • The simple epithelial keratins, K7, K8 and K18, were found in small amounts in the specimens from younger individuals, mainly in epibasal cells of the apex of the matrix and in putative Merkel cells [26].

Analytical, diagnostic and therapeutic context of Merkel Cells


  1. Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. Schlagbauer-Wadl, H., Klosner, G., Heere-Ress, E., Waltering, S., Moll, I., Wolff, K., Pehamberger, H., Jansen, B. J. Invest. Dermatol. (2000) [Pubmed]
  2. Merkel cells and prurigo nodularis. Nahass, G.T., Penneys, N.S. J. Am. Acad. Dermatol. (1994) [Pubmed]
  3. Anti-cytokeratin 20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma. Mahmoodi, M., Asad, H., Salim, S., Kantor, G., Minimo, C. J. Cutan. Pathol. (2005) [Pubmed]
  4. Merked cells and sclerosing epithelial neoplasms. Abesamis-Cubillan, E., El-Shabrawi-Caelen, L., LeBoit, P.E. The American Journal of dermatopathology. (2000) [Pubmed]
  5. Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. Salama, M.E., Azam, M., Ma, C.K., Ormsby, A., Zarbo, R.J., Amin, M.B., Lee, M.W. Arch. Pathol. Lab. Med. (2004) [Pubmed]
  6. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Airaksinen, M.S., Koltzenburg, M., Lewin, G.R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K.V., Thoenen, H., Meyer, M. Neuron (1996) [Pubmed]
  7. Molecular profiling reveals synaptic release machinery in Merkel cells. Haeberle, H., Fujiwara, M., Chuang, J., Medina, M.M., Panditrao, M.V., Bechstedt, S., Howard, J., Lumpkin, E.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Moll, R., Löwe, A., Laufer, J., Franke, W.W. Am. J. Pathol. (1992) [Pubmed]
  9. Neuron-specific enolase in the Merkel cells of mammalian skin. The use of specific antibody as a simple and reliable histologic marker. Gu, J., Polak, J.M., Tapia, F.J., Marangos, P.J., Pearse, A.G. Am. J. Pathol. (1981) [Pubmed]
  10. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. Michel, M., Török, N., Godbout, M.J., Lussier, M., Gaudreau, P., Royal, A., Germain, L. J. Cell. Sci. (1996) [Pubmed]
  11. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Leonard, J.H., Cook, A.L., Van Gele, M., Boyle, G.M., Inglis, K.J., Speleman, F., Sturm, R.A. Int. J. Cancer (2002) [Pubmed]
  12. The appearance, density, and distribution of Merkel cells in human embryonic and fetal skin: their relation to sweat gland and hair follicle development. Kim, D.K., Holbrook, K.A. J. Invest. Dermatol. (1995) [Pubmed]
  13. Transient expression of a functional serotonin transporter in Merkel cells during late gestation and early postnatal rat development. Hansson, S.R., Hoffman, B.J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2000) [Pubmed]
  14. Apoptosis of Merkel cells in neurotrophin-3 null mice. Halata, Z., Kucera, J., Kucera, T., Grim, M. Anat. Embryol. (2005) [Pubmed]
  15. Expression of MUC 1 and Ep-CAM in Merkel cell carcinomas: implications for immunotherapy. Kurzen, H., Kaul, S., Egner, U., Deichmann, M., Hartschuh, W. Arch. Dermatol. Res. (2003) [Pubmed]
  16. Postnatal loss of Merkel cells, but not of slowly adapting mechanoreceptors in mice lacking the neurotrophin receptor p75. Kinkelin, I., Stucky, C.L., Koltzenburg, M. Eur. J. Neurosci. (1999) [Pubmed]
  17. Expression of cytokeratin-20 in endometrial carcinoma. Zemer, R., Fishman, A., Bernheim, J., Zimlichman, S., Markowicz, O., Altaras, M., Klein, A. Gynecol. Oncol. (1998) [Pubmed]
  18. Presence and coexistence of chromogranin A and multiple neuropeptides in Merkel cells of mammalian oral mucosa. Gauweiler, B., Weihe, E., Hartschuh, W., Yanaihara, N. Neurosci. Lett. (1988) [Pubmed]
  19. Neural cell adhesion molecule immunoreactivity in Merkel cells and Merkel cell tumours. Gallego, R., García-Caballero, T., Fraga, M., Beiras, A., Forteza, J. Virchows Arch. (1995) [Pubmed]
  20. Merkel cells in vitro: production of nerve growth factor and selective interactions with sensory neurons. Vos, P., Stark, F., Pittman, R.N. Dev. Biol. (1991) [Pubmed]
  21. Immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in Merkel cells of various mammals: evidence for a neuromodulator function of the Merkel cell. Hartschuh, W., Weihe, E., Yanaihara, N., Reinecke, M. J. Invest. Dermatol. (1983) [Pubmed]
  22. Responsiveness and ultrastructure of slowly adapting type I cutaneous mechanoreceptors in vitamin A deficient rats. Baumann, K.I., Cheng-Chew, S.B., Hamann, W., Leung, M.S. J. Physiol. (Lond.) (1986) [Pubmed]
  23. Voltage-dependent currents in isolated single Merkel cells of rats. Yamashita, Y., Akaike, N., Wakamori, M., Ikeda, I., Ogawa, H. J. Physiol. (Lond.) (1992) [Pubmed]
  24. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Lundquist, K., Kohler, S., Rouse, R.V. Am. J. Surg. Pathol. (1999) [Pubmed]
  25. Neurotrophin-3 signaling in mammalian Merkel cell development. Szeder, V., Grim, M., Kucera, J., Sieber-Blum, M. Dev. Dyn. (2003) [Pubmed]
  26. Keratin expression in the normal nail unit: markers of regional differentiation. De Berker, D., Wojnarowska, F., Sviland, L., Westgate, G.E., Dawber, R.P., Leigh, I.M. Br. J. Dermatol. (2000) [Pubmed]
  27. Intraepidermal formation of Merkel cells in xenografts of human fetal skin. Moll, I., Lane, A.T., Franke, W.W., Moll, R. J. Invest. Dermatol. (1990) [Pubmed]
  28. Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites. Fradette, J., Larouche, D., Fugère, C., Guignard, R., Beauparlant, A., Couture, V., Caouette-Laberge, L., Roy, A., Germain, L. J. Invest. Dermatol. (2003) [Pubmed]
  29. Met enkephalin-like immunoreactivity in Merkel cells. Hartschuh, W., Weihe, E., Büchler, M., Helmstaedter, V., Feurle, G.E., Forssmann, W.G. Cell Tissue Res. (1979) [Pubmed]
  30. Ultrastructural study of the Merkel cell and its expression of met-enkephalin immunoreactivity during fetal and postnatal development in mice. Cheng Chew, S.B., Leung, P.Y. J. Anat. (1994) [Pubmed]
  31. Identification of Merkel cells in human skin by specific cytokeratin antibodies: changes of cell density and distribution in fetal and adult plantar epidermis. Moll, R., Moll, I., Franke, W.W. Differentiation (1984) [Pubmed]
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