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Gene Review

GNAS-AS1  -  GNAS antisense RNA 1

Homo sapiens

Synonyms: GNAS-AS, GNAS1AS, GNASAS, NCRNA00075, NESP-AS, ...
 
 
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Disease relevance of NESPAS

  • Previous work from our laboratory suggested that the trans-acting defect which allows packaging of cellular mRNA mapped to the provirus but did not map to the nucleocapsid region of the gag gene (D.J. Anderson, P. Lee, K. L. Levine, J. Sang, S. A. Shah, O. O. Yang, P. R. Shank, and M. L. Linial, J. Virol. 66:204-216, 1992) [1].
  • Primary central nervous system lymphomas in 72 immunocompetent patients: pathologic findings and clinical correlations. Groupe Ouest Est d'étude des Leucénies et Autres Maladies du Sang (GOELAMS) [2].
  • Retraction: Finfer S, Norton R, Bellomo R, Boyce N, French J, Myburch J, on behalf of the SAFE Study Investigators. The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill. Vox Sang 2004; 87 (Suppl. 2): S123-S131 [3].
  • Treatment of patients with advanced or bulky Hodgkin disease with a 12-week doxorubicin, bleomycin, vinblastine, and dacarbazine-like chemotherapy regimen followed by extended-field, full-dose radiotherapy: long-term results of the Groupe Ouest et Est des Leucémies et Autres Maladies de Sang H90-A/B Multicenter Randomized Trial [4].
  • Case report by Dr. Sang Duk Lee. Treatment of Class III malocclusion by sagittal appliance and fixed appliance [5].
 

High impact information on NESPAS

  • It appears, rather, to be caused by a failure in gene expression because one-third of Pk X p hybrids became able to express P antigenicity with a time lag of 3-4 days after cell fusion [Fellous, M., Gerbal, A., Nobillot, G. & Weils, J. (1977) Vox Sang. 32, 262-268] [6].
  • The Rhnull cells, originally described by Seidl, Spielmann, and Martin (Vox Sang. 23:182, 1972) were normal in size, cation, and water content, indicating no significant increase in cell volume as occurs in young human red cells [7].
  • The Genetics Society Autumn Meeting on the genetics of domestication took place in November 2004 at the Royal Society in London, and was organised by Helen Sang (Roslin Institute, UK) and Jonathan Jones (John Innes Centre, UK) [8].
  • Crude extracts from Salvia sclarea seeds were known to contain a lectin which specifically agglutinates Tn erythrocytes (Bird, G. W. G., and Wingham, G. (1974) Vox Sang. 26, 163-166) [9].
  • When poly(ethylene glycol) 3350 is estimated by the method of Skoog [(1979) Vox Sang. 37, 345-349], fine particles form [10].
 

Associations of NESPAS with chemical compounds

  • Patients aged 18-60 years received the Groupe Ouest Est d'Etude des Leucemies Aigues et Maladies du Sang (GOELAMS) 02 protocol: 3 monthly cycles of VCAP (vindesine 3 mg/m2 day 1, doxorubicin 80 mg/m2 day 2, cyclophosphamide 1500 mg/m2 day 2, and prednisone 80 mg/m2 days 1-5) [11].
  • Dr Jean Plouët (Centre de Recherche Cardiovasculaire, INSERM U 689/Institut des Vaisseaux et du Sang) was interviewed by Emma Quigley (Commissioning Editor, Expert Opinion) on 20th June 2006 [12].
  • The traditional medicine prescribed was Petch Sang Kart and the modern alternative was Proctosedyl [13].
  • The Yellow Emperor's Internal Medicine (Nei-Jing) describes the relationship between five internal organs corresponding to five different meridians and five oriental musical tones such as Gung (spleen), Sang (liver), Gak (liver), Chi (heart), Wu (kidney) [14].
 

Analytical, diagnostic and therapeutic context of NESPAS

References

  1. The packaging phenotype of the SE21Q1b provirus is related to high proviral expression and not trans-acting factors. Anderson, D.J., Stone, J., Lum, R., Linial, M.L. J. Virol. (1995) [Pubmed]
  2. Primary central nervous system lymphomas in 72 immunocompetent patients: pathologic findings and clinical correlations. Groupe Ouest Est d'étude des Leucénies et Autres Maladies du Sang (GOELAMS). Camilleri-Broët, S., Martin, A., Moreau, A., Angonin, R., Hénin, D., Gontier, M.F., Rousselet, M.C., Caulet-Maugendre, S., Cuillière, P., Lefrancq, T., Mokhtari, K., Morcos, M., Broët, P., Kujas, M., Hauw, J.J., Desablens, B., Raphaël, M. Am. J. Clin. Pathol. (1998) [Pubmed]
  3. Retraction: Finfer S, Norton R, Bellomo R, Boyce N, French J, Myburch J, on behalf of the SAFE Study Investigators. The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill. Vox Sang 2004; 87 (Suppl. 2): S123-S131. Mayr, W., Prowse, C. Vox Sang. (2004) [Pubmed]
  4. Treatment of patients with advanced or bulky Hodgkin disease with a 12-week doxorubicin, bleomycin, vinblastine, and dacarbazine-like chemotherapy regimen followed by extended-field, full-dose radiotherapy: long-term results of the Groupe Ouest et Est des Leucémies et Autres Maladies de Sang H90-A/B Multicenter Randomized Trial. Djeridane, M., Oudard, S., Escoffre-Barbe, M., Lacotte-Thierry, L., Desablens, B., Briére, J., Dib, M., Cassasus, P., Ghandour, C., Lamy, T., Lejeune, F., Simon, M., Traullé, C., Vigier, M., Maisonneuve, H., Briére, J., Colonna, P., Andrieu, J.M. Cancer (2002) [Pubmed]
  5. Case report by Dr. Sang Duk Lee. Treatment of Class III malocclusion by sagittal appliance and fixed appliance. Lee, S.D. The Functional orthodontist. (1990) [Pubmed]
  6. Defects of glycosyltransferase activities in human fibroblasts of Pk and p blood group phenotypes. Kijimoto-Ochiai, S., Naiki, M., Makita, A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  7. Increased potassium transport and ouabain binding in human Rhnull red blood cells. Lauf, P.K., Joiner, C.H. Blood (1976) [Pubmed]
  8. A walk from the wild side: the genetics of domestication of livestock and crops. Goodrich, J., Wiener, P. Bioessays (2005) [Pubmed]
  9. Isolation and characterization of an N-acetylgalactosamine specific lectin from Salvia sclarea seeds. Piller, V., Piller, F., Cartron, J.P. J. Biol. Chem. (1986) [Pubmed]
  10. Poly(ethylene glycol) quantitation by laser nephelometry. Cole, S.C., Christensen, G.A., Olson, W.P. Anal. Biochem. (1983) [Pubmed]
  11. Stage I-IIE primary non-Hodgkin's lymphoma of the testis: results of a prospective trial by the GOELAMS Study Group. Linassier, C., Desablens, B., Lefrancq, T., Le Prise, P.Y., Harousseau, J.L., Jacob, C., Gandhour, C., Haillot, O., Lucas, V., Leloup, R., Escoffre, M., Colombat, P., Tabuteau, S. Clinical lymphoma. (2002) [Pubmed]
  12. Inhibiting angiogenesis: interview with Dr Jean Plouët. Interview by Emma Quigley. Plouët, J. Expert Opin. Ther. Targets (2006) [Pubmed]
  13. Prescription pattern for treatment of hemorrhoids under the universal coverage policy of Thailand. Laosee, O.C., Pathanapornpandh, N., Sitthi-amorn, C., Khiewyoo, J., Somrongthong, R., Dulyavoranun, N. Southeast Asian J. Trop. Med. Public Health (2005) [Pubmed]
  14. An examination of the relationship between five oriental musical tones and corresponding internal organs and meridians. Kim, Y.C., Jeong, D.M., Lee, M.S. Acupuncture & electro-therapeutics research. (2004) [Pubmed]
  15. Use of a novel hepatitis C virus (HCV) major-epitope chimeric polypeptide for diagnosis of HCV infection. Chien, D.Y., Arcangel, P., Medina-Selby, A., Coit, D., Baumeister, M., Nguyen, S., George-Nascimento, C., Gyenes, A., Kuo, G., Valenzuela, P. J. Clin. Microbiol. (1999) [Pubmed]
  16. Intensive therapy before or during the conditioning regimen of allogeneic marrow transplantation in adult acute lymphoblastic leukemia patients: we must choose to reduce Toxicity--a Groupe Ouest-Est d'Etude des Leucemies et Autres Maladies du Sang study. Deconinck, E., Hunault, M., Milpied, N., Bernard, M., Renaud, M., Desablens, B., Delain, M., Witz, F., Lioure, B., Pignon, B., Guyotat, D., Berthou, C., Jouet, J.P., Casassus, P., Ifrah, N., Boiron, J.M. Biol. Blood Marrow Transplant. (2005) [Pubmed]
 
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