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Gene Review

PEBP4  -  phosphatidylethanolamine-binding protein 4

Homo sapiens

Synonyms: CORK-1, CORK1, GWTM1933, HEL-S-300, MGC22776, ...
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Disease relevance of PEBP4

  • Given that MCF-7 breast cancer cells expressed hPEBP4 at a high level, small interfering RNA was used to silence the expression of hPEBP4 [1].
  • All these data indicate that silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer [2].
  • All patients attended the hepatitis C clinic at Cork University Hospital, Cork, Ireland. The study group was homogeneous with respect to gender, hepatitis C virus (HCV) genotype (1b), and duration of infection [3].
  • We showed that the CAEV molecular clone from the Cork isolate was dUTPase defective as a result of a single amino acid substitution [4].
  • The non-fatal deliberate taking of overdoses in Cork city during 1982 was investigated from records in the general hospitals [5].
  • HPEBP4 expression in prostate cancer can activate Akt and deactivate ERK1/2 signaling, leading to TRAIL resistance [6].

Psychiatry related information on PEBP4

  • Based on these results, some concern about the dietary habits and the related health consequences in Cork adolescents appears justified [7].
  • The study evaluates the effectiveness of a sibling support programme (Sibshops) involving three disability agencies in Cork, Ireland. Qualitative and quantitative data were obtained using semi-structured interviews and the Piers-Harris Children's Self-Concept Scale with siblings, together with parent feedback [8].
  • Experiment 1 was modeled after a study by Dorfman, Kihlstrom, Cork, and Misiaszek (1995), in which direct instructions to respond more leniently led to an increase in recognition accuracy in patients with ECT-induced amnesia [9].
  • General Practitioners from Cork City and its environs were sent a questionnaire regarding their experience of parasuicide in the previous twelve months [10].

High impact information on PEBP4


Biological context of PEBP4

  • We demonstrate that silencing of hPEBP4 in CaoV-3 ovarian cancer cells potentiates TRAIL-induced apoptosis [2].
  • Silencing of human phosphatidylethanolamine-binding protein 4 sensitizes breast cancer cells to tumor necrosis factor-alpha-induced apoptosis and cell growth arrest [12].
  • The data indicated that turbot exposed to sediments from Cork Harbor elicited a significant increase in DNA damage in comparison with those exposed to sediment from the reference site and that exposure to the contaminated sediments caused a multi-organ genotoxic response [13].
  • BACKGROUND: A specialist patch test clinic was set up in April 1997 at the Department of Dermatology, South Infirmary-Victoria Hospital, Cork, Ireland. The number of batteries available was expanded from six to 21 and the routine testing of patients to their own products was introduced, as was prick testing for latex hypersensitivity [14].
  • Participants were drawn from the practice lists of 17 general practices in Cork and Kerry using stratified random sampling [15].

Anatomical context of PEBP4

  • The incidence of cancer of the central nervous system (CNS) was established for the counties of Cork and Kerry using the Southern Tumour Registry data base [16].
  • Conclusions: The quality of root canal fillings placed in single-rooted teeth by undergraduate dental students at the University Dental School and Hospital, Cork was acceptable (63% of root fillings placed in single rooted teeth were graded as 'adequate') [17].

Associations of PEBP4 with chemical compounds

  • Five thousand eight hundred four men and women in addition to receiving advice on diet and smoking, have been randomized equally to treatment with 40 mg pravastatin/day or matching placebo in 3 centers (Cork, Ireland, Glasgow, Scotland, and Leiden, The Netherlands) [18].
  • The University College Cork-based Probiotic Research Group has successfully isolated and identified lactic acid bacteria (LAB) which exhibit beneficial probiotic traits [19].
  • Gadodiamide (Omniscan, Amersham Health, Cork, Ireland) and gadoversetamide (OptiMARK, Mallinckrodt, St. Louis, MO) did produce noticeable-and therefore potentially misleading-effects at these concentrations [20].
  • The mean 24-h fluoride excretion in fluoridated Cork was 0.37 mg (+/-0.11) [21].
  • The sodium, potassium and creatinine contents of three non-consecutive 24-h urine samples collected by 34 selected adult individuals (10 m; 24 f) living in Cork City were determined [22].

Analytical, diagnostic and therapeutic context of PEBP4

  • We found that endogenous hPEBP4 interacts with Raf-1 and MEK1 in TRAIL-treated CaoV-3 cells by co-immunoprecipitation analysis [2].
  • Regarding attitudes, respondents from Cork were most favorable toward alternative medicine use and least favorable toward conventional medicine [23].
  • Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay [13].
  • Participants were recruited from the Bone Densitometry Unit of Cork University Hospital, including 381 postmenopausal women aged 61.26 +/- 8.50 (mean +/- SD) and 130 premenopausal women aged 46.30 +/- 6.50 (mean +/- SD) [24].
  • An emergency neurosurgical teleradiology system was initially installed in two referring hospitals in ireland to transmit images to the neurosurgical department in Cork [25].


  1. A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. Wang, X., Li, N., Liu, B., Sun, H., Chen, T., Li, H., Qiu, J., Zhang, L., Wan, T., Cao, X. J. Biol. Chem. (2004) [Pubmed]
  2. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. Li, P., Wang, X., Li, N., Kong, H., Guo, Z., Liu, S., Cao, X. Int. J. Mol. Med. (2006) [Pubmed]
  3. Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study. Fanning, L., Kenny-Walsh, E., Levis, J., Choudhury, K.R., Cannon, B., Sheehan, M., Whelton, M., Shanahan, F. Hepatology (2000) [Pubmed]
  4. Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses. Turelli, P., Pétursson, G., Guiguen, F., Mornex, J.F., Vigne, R., Quérat, G. J. Virol. (1996) [Pubmed]
  5. Social determinants of self-poisoning. Daly, M., Conway, M., Kelleher, M.J. The British journal of psychiatry : the journal of mental science. (1986) [Pubmed]
  6. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. Li, H., Wang, X., Li, N., Qiu, J., Zhang, Y., Cao, X. J. Biol. Chem. (2007) [Pubmed]
  7. Nutrition and lifestyle survey of 15-17 year old second level school pupils in the Cork city area. McElligott-Tangney, P., Morrissey, P.A. Irish medical journal. (2001) [Pubmed]
  8. Sibshops: an evaluation of an interagency model. D'Arcy, F., Flynn, J., McCarthy, Y., O'Connor, C., Tierney, E. Journal of intellectual disabilities : JOID. (2005) [Pubmed]
  9. Recognition memory in amnesia: effects of relaxing response criteria. Verfaellie, M., Giovanello, K.S., Keane, M.M. Cognitive, affective & behavioral neuroscience. (2001) [Pubmed]
  10. Parasuicide and general practice: a pilot study. Fitzsimons, M.M., Kelleher, M.J., Keeley, H.S., Corcoran, P., Byrne, S., Williamson, E., Burke, U. Irish medical journal. (1997) [Pubmed]
  11. Motor unit behavior in canine motor neuron disease. Pinter, M.J., Waldeck, R.F., Wallace, N., Cork, L.C. J. Neurosci. (1995) [Pubmed]
  12. Silencing of human phosphatidylethanolamine-binding protein 4 sensitizes breast cancer cells to tumor necrosis factor-alpha-induced apoptosis and cell growth arrest. Wang, X., Li, N., Li, H., Liu, B., Qiu, J., Chen, T., Cao, X. Clin. Cancer Res. (2005) [Pubmed]
  13. Genotoxicity of field-collected inter-tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay. Kilemade, M.F., Hartl, M.G., Sheehan, D., Mothersill, C., Van Pelt, F.N., O'Halloran, J., O'Brien, N.M. Environ. Mol. Mutagen. (2004) [Pubmed]
  14. The importance of a dedicated patch test clinic. Ormond, P., Hazelwood, E., Bourke, B., Lyons, J.F., Bourke, J.F. Br. J. Dermatol. (2002) [Pubmed]
  15. Established cardiovascular disease and CVD risk factors in a primary care population of middle-aged Irish men and women. Creagh, D., Neilson, S., Collins, A., Colwell, N., Hinchion, R., Drew, C., O'Halloran, D., Perry, I.J. Irish medical journal. (2002) [Pubmed]
  16. Epidemiology of tumours of the central nervous system in Ireland. Crowley, M.J., O'Brien, D.F. Irish medical journal. (1993) [Pubmed]
  17. Quality of root canal fillings performed by undergraduate dental students on single-rooted teeth*. Lynch, C.D., Burke, F.M. European journal of dental education : official journal of the Association for Dental Education in Europe. (2006) [Pubmed]
  18. The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Shepherd, J., Blauw, G.J., Murphy, M.B., Cobbe, S.M., Bollen, E.L., Buckley, B.M., Ford, I., Jukema, J.W., Hyland, M., Gaw, A., Lagaay, A.M., Perry, I.J., Macfarlane, P.W., Meinders, A.E., Sweeney, B.J., Packard, C.J., Westendorp, R.G., Twomey, C., Stott, D.J. Am. J. Cardiol. (1999) [Pubmed]
  19. Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Dunne, C., Murphy, L., Flynn, S., O'Mahony, L., O'Halloran, S., Feeney, M., Morrissey, D., Thornton, G., Fitzgerald, G., Daly, C., Kiely, B., Quigley, E.M., O'Sullivan, G.C., Shanahan, F., Collins, J.K. Antonie Van Leeuwenhoek (1999) [Pubmed]
  20. Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing. Löwe, A., Balzer, T., Hirt, U. Investigative radiology. (2005) [Pubmed]
  21. Urinary fluoride excretion by preschool children in six European countries. Ketley, C.E., Cochran, J.A., Holbrook, W.P., Sanches, L., van Loveren, C., Oila, A.M., O'Mullane, D.M. Community dentistry and oral epidemiology. (2004) [Pubmed]
  22. Assessment of sodium and potassium intakes. Shortt, C., Flynn, A., Morrissey, P.A. European journal of clinical nutrition. (1988) [Pubmed]
  23. An international survey of the use and attitudes regarding alternative medicine by patients with inflammatory bowel disease. Rawsthorne, P., Shanahan, F., Cronin, N.C., Anton, P.A., Löfberg, R., Bohman, L., Bernstein, C.N. Am. J. Gastroenterol. (1999) [Pubmed]
  24. Investigation of the genetic influence of the OPG, VDR (Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population. Wynne, F., Drummond, F., O'Sullivan, K., Daly, M., Shanahan, F., Molloy, M.G., Quane, K.A. Calcif. Tissue Int. (2002) [Pubmed]
  25. Report of a national neurosurgical teleradiology system. Gray, W.P., Somers, J., Buckley, T.F. Journal of telemedicine and telecare. (1997) [Pubmed]
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