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Maz  -  MYC-associated zinc finger protein (purine...

Mus musculus

Synonyms: MAZI, Myc-associated zinc finger protein, PUR1, Pur-1, Purine-binding transcription factor, ...
 
 
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Disease relevance of Maz

 

High impact information on Maz

 

Biological context of Maz

 

Anatomical context of Maz

  • In vivo evidence of SAF-1 and PKA-Calpha interaction was further revealed by coimmunoprecipitation of these two proteins in cAMP-activated liver cells [6].
  • In a comparison of SAF-1 and Freund's adjuvant, SAF-1 was superior to Freund's adjuvant in eliciting polyclonal and hybridoma antibodies which neutralized the biological activity of IL-1 alpha [8].
 

Associations of Maz with chemical compounds

  • A similar order of adjuvant efficacy: Freund's greater than alum greater than Squalene Arlacel greater than SAF-1, was observed in rabbits [9].
 

Other interactions of Maz

  • Immune responses induced by TCR vaccines formulated with various adjuvants: QS-21, IL-12, SAF-1, CD40L, and GM-CSF were compared [10].
  • QS-21, IL-12, and SAF-1 biased the humoral immune response toward Th1-type, reflected by the induction of IgG2a and IgG2b anti-C6VL TCR Abs [10].
 

Analytical, diagnostic and therapeutic context of Maz

  • Electrophoresis mobility shift assay revealed that Myc-associated zinc finger protein (MAZ) as well as SP1/3 binds a GA box in this region [11].
  • Immunofluorescence and combined immunoprecipitation-Western blot analyses revealed colocalization and interaction between SAF-1 and PKA-Calpha [6].
  • By chromatin immunoprecipitation assay, in vivo, markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients [3].

References

  1. Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis. Ray, A., Shakya, A., Kumar, D., Benson, M.D., Ray, B.K. J. Immunol. (2006) [Pubmed]
  2. Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. Kennedy, G.C., Rutter, W.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Vascular Endothelial Growth Factor Expression in Arthritic Joint Is Regulated by SAF-1 Transcription Factor. Ray, B.K., Shakya, A., Ray, A. J. Immunol. (2007) [Pubmed]
  4. Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. Song, J., Murakami, H., Tsutsui, H., Ugai, H., Geltinger, C., Murata, T., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K., Yokoyama, K.K. Eur. J. Biochem. (1999) [Pubmed]
  5. Structural gene organization and evolutionary aspects of the V-ATPase accessory subunit Ac45. Schoonderwoert, V.T., Martens, G.J. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Catalytic subunit of protein kinase A is an interacting partner of the inflammation-responsive transcription factor serum amyloid A-activating factor-1. Ray, B.K., Chen, J., Ray, A. J. Immunol. (2001) [Pubmed]
  7. Enhancement of antibody responses to influenza B virus haemagglutinin by use of a new adjuvant formulation. Byars, N.E., Allison, A.C., Harmon, M.W., Kendal, A.P. Vaccine (1990) [Pubmed]
  8. Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies. Kenney, J.S., Hughes, B.W., Masada, M.P., Allison, A.C. J. Immunol. Methods (1989) [Pubmed]
  9. Peptide vaccines derived from a malarial surface antigen: effects of dose and adjuvants on immunogenicity. Jones, G.L., Spencer, L., Lord, R., Mollard, R., Pye, D., Saul, A. Immunol. Lett. (1990) [Pubmed]
  10. TCR vaccines against T cell lymphoma: QS-21 and IL-12 adjuvants induce a protective CD8+ T cell response. Wong, C.P., Okada, C.Y., Levy, R. J. Immunol. (1999) [Pubmed]
  11. Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Wu, C.X., Zhao, W.P., Kishi, H., Dokan, J., Jin, Z.X., Wei, X.C., Yokoyama, K.K., Muraguchi, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
 
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