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Gene Review

Mbl1  -  mannose-binding lectin (protein A) 1

Mus musculus

Synonyms: MBL-A, MBP-A, Mannan-binding protein, Mannose-binding protein A, Ra-reactive factor polysaccharide-binding component p28B, ...
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Disease relevance of Mbl1

  • We infected MBL-A and MBL-C double knock-out mice (DKO) with HSV-2 via the intraperitoneal (i.p.) route [1].
  • We found MBL-A null mice had enhanced survival in a septic peritonitis model compared to wild-type mice and complement 3 null mice at 24 h, 48 h and 10 d (P < 0.05) [2].
  • We conclude that MBL-A deficiency does not alter resistance to disseminated candidiasis or initial hepatic invasion by P. yoelii [3].

High impact information on Mbl1


Biological context of Mbl1


Anatomical context of Mbl1

  • In addition to liver, S-MBP mRNA was detected in lung, kidney, and testis, and L-MBP mRNA was detected in kidney, thymus, and small intestine [9].
  • In vitro studies indicate that bacteria opsonized with MBL-A-deficient serum induced significantly less cytokine by peritoneal macrophages compared to those with wild-type serum [2].
  • In the sensitized MBL-A-/- mice, whole lung T helper cell type 2 cytokine levels were significantly decreased at day 4 after conidia, and whole lung interferon-gamma levels were significantly increased at day 28 after conidia when compared with controls [10].
  • These results suggest the presence of a special antigenic marker on activated murine T and B cells which differs from the generally recognized cell surface antigens, such as H-2, Ig, Ala-I, idiotype, Thy-I, MBLA, MTLA, Lyt-1,2,3, and others [11].

Associations of Mbl1 with chemical compounds

  • Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes [8].
  • The sequence of 14 NH2-terminal amino acid residues of the molecule showed 93% identity to rat MBP-A and complete identity to the translated cDNA sequences for mouse MBP-A and mouse Ra-reactive factor component P28b (RaRF P28b) published previously [12].
  • A major cell surface glycoprotein bearing S-MBP ligands was isolated and identified as CD45RO, which is a transmembrane protein with tyrosine phosphatase activity [7].
  • On sucrose density gradient centrifugation the sedimentation velocities of MBL-A and MBL-C were estimated at 7.3 S and 10.8 S, respectively [13].
  • After the induction of acute phase responses by intraperitoneal injection of either casein or lipopolysaccharide (LPS), MBL-A was found to increase approximately two-fold, with a maximum after 32 h, while MBL-C did not increase significantly [13].

Analytical, diagnostic and therapeutic context of Mbl1


  1. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva, M., Paludan, S.R., Thiel, S., Slavov, V., Ruseva, M., Eriksson, K., Löwhagen, G.B., Shi, L., Takahashi, K., Ezekowitz, A., Jensenius, J.C. Clin. Exp. Immunol. (2004) [Pubmed]
  2. Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Takahashi, K., Gordon, J., Liu, H., Sastry, K.N., Epstein, J.E., Motwani, M., Laursen, I., Thiel, S., Jensenius, J.C., Carroll, M., Ezekowitz, R.A. Microbes Infect. (2002) [Pubmed]
  3. Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice. Lee, S.J., Gonzalez-Aseguinolaza, G., Nussenzweig, M.C. Mol. Cell. Biol. (2002) [Pubmed]
  4. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries, B., Walter, S.J., Peutz-Kootstra, C.J., Wolfs, T.G., van Heurn, L.W., Buurman, W.A. Am. J. Pathol. (2004) [Pubmed]
  5. Differential expression of the murine mannose-binding lectins A and C in lymphoid and nonlymphoid organs and tissues. Wagner, S., Lynch, N.J., Walter, W., Schwaeble, W.J., Loos, M. J. Immunol. (2003) [Pubmed]
  6. Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor. Mullin, N.P., Hitchen, P.G., Taylor, M.E. J. Biol. Chem. (1997) [Pubmed]
  7. A unique CD45 glycoform recognized by the serum mannan-binding protein in immature thymocytes. Uemura, K., Yokota, Y., Kozutsumi, Y., Kawasaki, T. J. Biol. Chem. (1996) [Pubmed]
  8. Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes. Sastry, R., Wang, J.S., Brown, D.C., Ezekowitz, R.A., Tauber, A.I., Sastry, K.N. Mamm. Genome (1995) [Pubmed]
  9. L-MBP is expressed in epithelial cells of mouse small intestine. Uemura, K., Saka, M., Nakagawa, T., Kawasaki, N., Thiel, S., Jensenius, J.C., Kawasaki, T. J. Immunol. (2002) [Pubmed]
  10. Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile. Hogaboam, C.M., Takahashi, K., Ezekowitz, R.A., Kunkel, S.L., Schuh, J.M. J. Leukoc. Biol. (2004) [Pubmed]
  11. ACA-1, a new differentiation antigen of activated lymphoid cells. Nesterenko, V.G., Novikova, T.K., Fontalin, L.N., Rubakova, E.I., Gruner, S., Wechnik, E., Sidorova, E.V. Cell. Immunol. (1983) [Pubmed]
  12. Purification and characterization of mannan-binding protein from mouse serum. Holt, P., Holmskov, U., Thiel, S., Teisner, B., Højrup, P., Jensenius, J.C. Scand. J. Immunol. (1994) [Pubmed]
  13. Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses. Liu, H., Jensen, L., Hansen, S., Petersen, S.V., Takahashi, K., Ezekowitz, A.B., Hansen, F.D., Jensenius, J.C., Thiel, S. Scand. J. Immunol. (2001) [Pubmed]
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