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Mbl2  -  mannose-binding lectin (protein C) 2

Mus musculus

Synonyms: L-MBP, MBL, MBL-C, MBP-C, Mannan-binding protein, ...
 
 
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Disease relevance of Mbl2

  • Results of the passive hemolysis experiment using sheep erythrocytes coated with yeast mannan suggest that this MBP has the ability to activate complement [1].
  • The objective of this study is to investigate the involvement of MBP in IgA nephropathy by using HIGA mice, which spontaneously develop a glomerulonephritis resembling human IgA nephropathy [2].
  • We have found that MBP recognizes and binds specifically to oligosaccharide ligands expressed on the surfaces of a human colorectal carcinoma [3].
  • Taken together, the data show that MBL modulates the response to HSV-2 in mice by affecting neutralization of the virus [4].
  • CONCLUSIONS: These results indicate that neither MBL nor activation of the complement cascade is crucial for the induction of anaphylaxis [5].
 

High impact information on Mbl2

 

Chemical compound and disease context of Mbl2

 

Biological context of Mbl2

 

Anatomical context of Mbl2

 

Associations of Mbl2 with chemical compounds

 

Other interactions of Mbl2

  • The results implicate SP-D and possibly MBL as important components of the innate defense of the respiratory tract against influenza virus and indicate that the degree or pattern of glycosylation of a virus can be an important factor in its virulence [14].
  • These results confirm an essential function for complement in host resistance against S. aureus infection but also identify an MBL-dependent mechanism that is C3 independent [15].
 

Analytical, diagnostic and therapeutic context of Mbl2

  • Quantitative RT-PCR revealed that the small intestine is a predominant site of extrahepatic expression of L-MBP [10].
  • The mannan-binding protein fraction of bovine serum that eluted with 100 mM mannose from a mannan-Sepharose column was analyzed under reducing conditions by SDS-PAGE [1].
  • The concentration of MBP in serum from normal mice was measured by rocket immunoelectrophoresis and found to be from below 1 microgram/ml to 100 micrograms/ml (average 50 micrograms/ml, n = 60) [13].
  • Kidney damages, which were evaluated by levels of blood urea nitrogen (BUN) and creatinine, showed that MBL DKO mice were significantly protected compared with WT mice [11].
  • Mice subjected to renal I/R displayed evident renal MBL-depositions, depending on the duration of warm ischemia, in the early reperfusion phase [16].

References

  1. Cloning and characterization of a cDNA encoding bovine mannan-binding protein. Kawai, T., Suzuki, Y., Eda, S., Ohtani, K., Kase, T., Fujinaga, Y., Sakamoto, T., Kurimura, T., Wakamiya, N. Gene (1997) [Pubmed]
  2. Deposition of mannan-binding protein in glomeruli of HIGA mice in the exacerbation of glomerulonephrites induced by lipopolysaccharide. Uemura, K., Shimosawa, M., Adachi, H., Liu, N., Muso, E., Kawasaki, T., Ono, T. Nephrology (Carlton, Vic.) (2005) [Pubmed]
  3. Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding proteindependent cell-mediated cytotoxicity. Ma, Y., Uemura, K., Oka, S., Kozutsumi, Y., Kawasaki, N., Kawasaki, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva, M., Paludan, S.R., Thiel, S., Slavov, V., Ruseva, M., Eriksson, K., Löwhagen, G.B., Shi, L., Takahashi, K., Ezekowitz, A., Jensenius, J.C. Clin. Exp. Immunol. (2004) [Pubmed]
  5. Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis. Windbichler, M., Echtenacher, B., Takahashi, K., Ezekowitz, R.A., Schwaeble, W.J., Jenseniuis, J.C., Männel, D.N. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  6. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. Shi, L., Takahashi, K., Dundee, J., Shahroor-Karni, S., Thiel, S., Jensenius, J.C., Gad, F., Hamblin, M.R., Sastry, K.N., Ezekowitz, R.A. J. Exp. Med. (2004) [Pubmed]
  7. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. Iwaki, D., Kanno, K., Takahashi, M., Endo, Y., Lynch, N.J., Schwaeble, W.J., Matsushita, M., Okabe, M., Fujita, T. J. Immunol. (2006) [Pubmed]
  8. Recognition of Candida albicans by Mannan-Binding Lectin In Vitro and In Vivo. Lillegard, J.B., Sim, R.B., Thorkildson, P., Gates, M.A., Kozel, T.R. J. Infect. Dis. (2006) [Pubmed]
  9. Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes. Sastry, R., Wang, J.S., Brown, D.C., Ezekowitz, R.A., Tauber, A.I., Sastry, K.N. Mamm. Genome (1995) [Pubmed]
  10. L-MBP is expressed in epithelial cells of mouse small intestine. Uemura, K., Saka, M., Nakagawa, T., Kawasaki, N., Thiel, S., Jensenius, J.C., Kawasaki, T. J. Immunol. (2002) [Pubmed]
  11. Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury. Møller-Kristensen, M., Wang, W., Ruseva, M., Thiel, S., Nielsen, S., Takahashi, K., Shi, L., Ezekowitz, A., Jensenius, J.C., Gadjeva, M. Scand. J. Immunol. (2005) [Pubmed]
  12. Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q. Hart, M.L., Ceonzo, K.A., Shaffer, L.A., Takahashi, K., Rother, R.P., Reenstra, W.R., Buras, J.A., Stahl, G.L. J. Immunol. (2005) [Pubmed]
  13. Purification and characterization of mannan-binding protein from mouse serum. Holt, P., Holmskov, U., Thiel, S., Teisner, B., Højrup, P., Jensenius, J.C. Scand. J. Immunol. (1994) [Pubmed]
  14. Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice. Reading, P.C., Morey, L.S., Crouch, E.C., Anders, E.M. J. Virol. (1997) [Pubmed]
  15. Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection. Takahashi, K., Shi, L., Gowda, L.D., Ezekowitz, R.A. Infect. Immun. (2005) [Pubmed]
  16. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries, B., Walter, S.J., Peutz-Kootstra, C.J., Wolfs, T.G., van Heurn, L.W., Buurman, W.A. Am. J. Pathol. (2004) [Pubmed]
 
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