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Gene Review

DYNC1I2  -  dynein, cytoplasmic 1, intermediate chain 2

Homo sapiens

Synonyms: Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein intermediate chain 2, DH IC-2, DNCI2, DNCIC2, ...
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Disease relevance of DYNC1I2

  • A major alteration of c-myc sequences in IC2 cells involved the insertion of a non-coding sequence into the second intron and their co-amplification with the third exon, without any evidence for the integration of HPV-16 sequences within or close to the gene [1].
  • To optimize the production of noninfectious HIV-like particles (VLPs) and potentially improve the effectiveness of the vaccine, we generated four potential vaccine constructs: the parental (IC2) and three modifications (IC25, IC48, and IC90) containing mutations within the HIV protease [2].
  • We previously described two genital carcinomas (IC2, IC4) containing human papillomavirus type 16 (HPV-16)- or HPV-18-related sequences integrated in chromosomal bands containing the c-myc (8q24) or N-myc (2p24) gene, respectively [1].

High impact information on DYNC1I2

  • Thus, EGF receptor-expressing IC2 cells provide a unique cellular system for in vitro study of mast cell differentiation [3].
  • These results indicate that the EGF receptor is functional in the pre-mast IC2 cells; EGF can support short-term proliferation and activates the signals that induce cell differentiation [3].
  • We show that the maternal germ-line methylation at IC2 and the imprinted expression of five genes of the IC2 domain are correctly reproduced on an 800 kb YAC transgene when transferred outside of their normal chromosomal context [4].
  • Surprisingly, KDY expression in IC2 cells triggered dramatic changes in cell size and the extent of granulation [5].
  • In this study, we have examined the transforming potential and biologic effects of a point mutation that results in substitution of the aspartic acid at codon 814 in the cytoplasmic kinase domain to tyrosine (D814Y) by introducing either wild-type (Kit) or mutant KitD814Y (KDY) cDNA into an interleukin-3-dependent mast cell line IC2 [5].

Biological context of DYNC1I2

  • 1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis [6].
  • Using in situ hybridization, HPV16 or 18 sequences were found at chromosome band 8q24, the localization of MYC, in IC1, IC2, IC3, IC6 and CAC-1 cells and at other sites in IC4, IC5, IC7 and IC8 cells [7].
  • The c-myc gene was rearranged and amplified in IC2 cells without evidence of overexpression [1].

Anatomical context of DYNC1I2

  • A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud [6].
  • Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS [6].
  • Using a beta-cell-specific monoclonal antibody IC2, modified with a radioisotope chelator for nuclear imaging, we showed that highly specific binding and accumulation to beta-cells occurs after intravenous administration of the probe, with virtually no binding to exocrine pancreas or stromal tissues [8].

Associations of DYNC1I2 with chemical compounds

  • Vanadate also stimulated synthesis of nucleotides and protein in IC2 cells [9].

Analytical, diagnostic and therapeutic context of DYNC1I2


  1. Distinct patterns of alteration of myc genes associated with integration of human papillomavirus type 16 or type 45 DNA in two genital tumours. Sastre-Garau, X., Favre, M., Couturier, J., Orth, G. J. Gen. Virol. (2000) [Pubmed]
  2. Optimization of a multi-gene HIV-1 recombinant subtype CRF02_AG DNA vaccine for expression of multiple immunogenic forms. Ellenberger, D., Li, B., Smith, J., Yi, H., Folks, T., Robinson, H., Butera, S. Virology (2004) [Pubmed]
  3. EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor. Wang, H.M., Collins, M., Arai, K., Miyajima, A. EMBO J. (1989) [Pubmed]
  4. The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Cerrato, F., Sparago, A., Di Matteo, I., Zou, X., Dean, W., Sasaki, H., Smith, P., Genesio, R., Bruggemann, M., Reik, W., Riccio, A. Hum. Mol. Genet. (2005) [Pubmed]
  5. A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells. Piao, X., Bernstein, A. Blood (1996) [Pubmed]
  6. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Crackower, M.A., Sinasac, D.S., Xia, J., Motoyama, J., Prochazka, M., Rommens, J.M., Scherer, S.W., Tsui, L.C. Genomics (1999) [Pubmed]
  7. MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors. Peter, M., Rosty, C., Couturier, J., Radvanyi, F., Teshima, H., Sastre-Garau, X. Oncogene (2006) [Pubmed]
  8. Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Moore, A., Bonner-Weir, S., Weissleder, R. Diabetes (2001) [Pubmed]
  9. Vanadate can replace interleukin 3 for transient growth of factor-dependent cells. Tojo, A., Kasuga, M., Urabe, A., Takaku, F. Exp. Cell Res. (1987) [Pubmed]
  10. The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface. Broudy, V.C., Lin, N.L., Sabath, D.F. Cytokine (2001) [Pubmed]
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