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Gene Review

ADORA1  -  adenosine A1 receptor

Homo sapiens

Synonyms: Adenosine receptor A1, RDC7
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Disease relevance of ADORA1


Psychiatry related information on ADORA1


High impact information on ADORA1


Chemical compound and disease context of ADORA1


Biological context of ADORA1


Anatomical context of ADORA1


Associations of ADORA1 with chemical compounds


Regulatory relationships of ADORA1


Other interactions of ADORA1


Analytical, diagnostic and therapeutic context of ADORA1


  1. Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist. Von Lubitz, D.K., Lin, R.C., Jacobson, K.A. Eur. J. Pharmacol. (1995) [Pubmed]
  2. Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells. Rego, A.C., Agostinho, P., Melo, J., Cunha, R.A., Oliveira, C.R. Exp. Eye Res. (2000) [Pubmed]
  3. Adenosine modulates cell proliferation in human colonic adenocarcinoma. I. Possible involvement of adenosine A1 receptor subtypes in HT29 cells. Lelièvre, V., Muller, J.M., Falcón, J. Eur. J. Pharmacol. (1998) [Pubmed]
  4. Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients. Mayne, M., Shepel, P.N., Jiang, Y., Geiger, J.D., Power, C. Ann. Neurol. (1999) [Pubmed]
  5. Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells. Ferré, S., Torvinen, M., Antoniou, K., Irenius, E., Civelli, O., Arenas, E., Fredholm, B.B., Fuxe, K. J. Biol. Chem. (1998) [Pubmed]
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  7. Adenosine A1 receptor and bipolar affective disorder: systematic screening of the gene and association studies. Deckert, J., Nöthen, M.M., Albus, M., Franzek, E., Rietschel, M., Ren, H., Stiles, G.L., Knapp, M., Weigelt, B., Maier, W., Beckmann, H., Propping, P. Am. J. Med. Genet. (1998) [Pubmed]
  8. Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. Von Lubitz, D.K., Beenhakker, M., Lin, R.C., Carter, M.F., Paul, I.A., Bischofberger, N., Jacobson, K.A. Eur. J. Pharmacol. (1996) [Pubmed]
  9. Modified electroconvulsive shock can induce rapid tolerance associated with adenosine A1 receptor activation subjected to focal cerebral ischemia in rats. Orito, K., Harada, H., Shigemori, M., Kano, T. Journal of neurosurgical anesthesiology. (2006) [Pubmed]
  10. DNA antisense therapy for asthma in an animal model. Nyce, J.W., Metzger, W.J. Nature (1997) [Pubmed]
  11. Preferential inhibition of omega-conotoxin-sensitive presynaptic Ca2+ channels by adenosine autoreceptors. Yawo, H., Chuhma, N. Nature (1993) [Pubmed]
  12. Effects of A1 adenosine receptor agonism using N6-cyclohexyl-2'-O-methyladenosine in patients with left ventricular dysfunction. Bertolet, B.D., Anand, I.S., Bryg, R.J., Mohanty, P.K., Chatterjee, K., Cohn, J.N., Khurmi, N.S., Pepine, C.J. Circulation (1996) [Pubmed]
  13. Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects. Lerman, B.B. Circulation (1993) [Pubmed]
  14. The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat. Walsh, M.P., Marshall, J.M. J. Physiol. (Lond.) (2006) [Pubmed]
  15. Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties. White, T.E., Dickenson, J.M., Hill, S.J. Br. J. Pharmacol. (1993) [Pubmed]
  16. Mechanisms of desflurane-induced preconditioning in isolated human right atria in vitro. Hanouz, J.L., Yvon, A., Massetti, M., Lepage, O., Babatasi, G., Khayat, A., Bricard, H., Gérard, J.L. Anesthesiology (2002) [Pubmed]
  17. Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells. Dickenson, J.M., Hill, S.J. Eur. J. Pharmacol. (1996) [Pubmed]
  18. Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells. Gerwins, P., Fredholm, B.B. Naunyn Schmiedebergs Arch. Pharmacol. (1995) [Pubmed]
  19. Adenosine deaminase and body mass index in non-insulin-dependent diabetes mellitus. Bottini, E., Gloria-Bottini, F. Metab. Clin. Exp. (1999) [Pubmed]
  20. Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function. Salmon, J.E., Brogle, N., Brownlie, C., Edberg, J.C., Kimberly, R.P., Chen, B.X., Erlanger, B.F. J. Immunol. (1993) [Pubmed]
  21. Localization of the adenosine A1 receptor subtype gene (ADORA1) to chromosome 1q32.1. Townsend-Nicholson, A., Baker, E., Schofield, P.R., Sutherland, G.R. Genomics (1995) [Pubmed]
  22. Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Townsend-Nicholson, A., Shine, J. Brain Res. Mol. Brain Res. (1992) [Pubmed]
  23. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Gadalla, A.E., Pearson, T., Currie, A.J., Dale, N., Hawley, S.A., Sheehan, M., Hirst, W., Michel, A.D., Randall, A., Hardie, D.G., Frenguelli, B.G. J. Neurochem. (2004) [Pubmed]
  24. The affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor. Cohen, F.R., Lazareno, S., Birdsall, N.J. Eur. J. Pharmacol. (1996) [Pubmed]
  25. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor. Dougherty, C., Barucha, J., Schofield, P.R., Jacobson, K.A., Liang, B.T. FASEB J. (1998) [Pubmed]
  26. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Johnston, J.B., Silva, C., Gonzalez, G., Holden, J., Warren, K.G., Metz, L.M., Power, C. Ann. Neurol. (2001) [Pubmed]
  27. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Angulo, E., Casadó, V., Mallol, J., Canela, E.I., Viñals, F., Ferrer, I., Lluis, C., Franco, R. Brain Pathol. (2003) [Pubmed]
  28. Neuroprotective role of adenosine in the CNS. Wardas, J. Polish journal of pharmacology. (2002) [Pubmed]
  29. Modulation of [3H]acetylcholine release from cultured amacrine-like neurons by adenosine A1 receptors. Santos, P.F., Santos, M.S., Carvalho, A.P., Duarte, C.B. J. Neurochem. (1998) [Pubmed]
  30. New targets in the acute treatment of headache. Goadsby, P.J. Curr. Opin. Neurol. (2005) [Pubmed]
  31. Modulation of the chemotactic peptide- and immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine. Zalavary, S., Bengtsson, T. Eur. J. Pharmacol. (1998) [Pubmed]
  32. Modulating effect of adenosine deaminase on function of adenosine A1 receptors. Sun, W.C., Cao, Y., Jin, L., Wang, L.Z., Meng, F., Zhu, X.Z. Acta Pharmacol. Sin. (2005) [Pubmed]
  33. Adenosine up-regulation of the mucin gene, MUC2, in asthma. McNamara, N., Gallup, M., Khong, A., Sucher, A., Maltseva, I., Fahy, J., Basbaum, C. FASEB J. (2004) [Pubmed]
  34. Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells. Cooper, D.M., Caldwell, K.K., Boyajian, C.L., Petcoff, D.W., Schlegel, W. Cell. Signal. (1989) [Pubmed]
  35. The role of adenosine-related genes variants in susceptibility to essential hypertension. Wright, K., Tajouri, L., Lea, R.A., Ovcaric, M., Heux, S., Morin, F., Bey, W., Headrick, J.P., Griffiths, L.R. J. Hypertens. (2004) [Pubmed]
  36. Transcriptional activation of c-Fos by constitutively active Galpha(16)QL through a STAT1-dependent pathway. Lo, R.K., Wong, Y.H. Cell. Signal. (2006) [Pubmed]
  37. Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia. Kronenwett, R., Butterweck, U., Steidl, U., Kliszewski, S., Neumann, F., Bork, S., Blanco, E.D., Roes, N., Gräf, T., Brors, B., Eils, R., Maercker, C., Kobbe, G., Gattermann, N., Haas, R. Oncogene (2005) [Pubmed]
  38. Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. Dickenson, J.M., Blank, J.L., Hill, S.J. Br. J. Pharmacol. (1998) [Pubmed]
  39. In vitro study of the effect of adenosine on frog adrenocortical cells. Feuilloley, M., Geymonat, M., Yon, L., Delarue, C., Fasolo, A., Vaudry, H. Gen. Comp. Endocrinol. (1992) [Pubmed]
  40. Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations. Schulte, G., Robertson, B., Fredholm, B.B., DeLander, G.E., Shortland, P., Molander, C. Neuroscience (2003) [Pubmed]
  41. Adenosine--an endogenous neuroprotective metabolite and neuromodulator. Deckert, J., Gleiter, C.H. J. Neural Transm. Suppl. (1994) [Pubmed]
  42. A selective adenosine A1 receptor antagonist attenuates renal dysfunction during controlled hypotension with adenosine in rats. Barrett, R.J., Wright, K.F. Anesth. Analg. (1994) [Pubmed]
  43. Alteration of adenosine A1 receptor binding in the post-ischaemic rat brain. Nagasawa, H., Araki, T., Kogure, K. Neuroreport (1994) [Pubmed]
  44. Endogenous protective mechanisms in myocardial ischemia: hibernation and ischemic preconditioning. Heusch, G., Schulz, R. Am. J. Cardiol. (1997) [Pubmed]
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