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Gene Review

CRMP1  -  collapsin response mediator protein 1

Homo sapiens

Synonyms: CRMP-1, Collapsin response mediator protein 1, DPYSL1, DRP-1, DRP1, ...
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Disease relevance of CRMP1


High impact information on CRMP1


Chemical compound and disease context of CRMP1

  • Although the molecular mechanisms of Sema3A-Npn-1 signaling are largely unknown, a pertussis toxin-sensitive trimeric G protein(s), Rac-1, collapsin response mediator protein (CRMP), cyclic nucleotides and tyrosine kinase(s) have been implicated as essential and/or modulatory components of these processes [7].

Biological context of CRMP1


Anatomical context of CRMP1

  • Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex [10].
  • To identify differentially expressed invasion-associated genes, we screened a panel of lung cancer cell lines (CL(1-0), CL(1-1), CL(1-5), and CL(1-5)-F(4) in order of increasing invasive activity) for such genes and selected one gene, collapsin response mediator protein-1 (CRMP-1), to characterize [3].
  • Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse [9].
  • However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities [9].
  • This mutant CRMP mimics the DRG neurite outgrowth-inhibiting effects of Sema3A and reduces Sema3A-induced axonal repulsion [11].

Associations of CRMP1 with chemical compounds

  • Alanine substitutions in one domain of CRMP1 produce a constitutively active protein that causes Sema3A-independent COS-7 contraction [11].
  • In the Reln(rl/rl) cortex, CRMP1 and Dab1 were expressed at a higher level, yet tyrosine phosphorylated at a lower level [10].
  • Muscle acetylcholine receptor binding and modulating antibodies, striational antibodies, and a neuronal autoantibody specific for collapsin response-mediator protein were detected [12].

Other interactions of CRMP1

  • The LD was significant between markers spaced about 208 kb apart in EVC, whereas no LD was found between a pair of markers located about 5 kb apart in CRMP1 [1].
  • Collapsin response mediator protein-2 (CRMP-2) is a member of the CRMP/TOAD/Ulip/DRP family of cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance [13].
  • We have defined a new paraneoplastic immunoglobulin G (IgG) autoantibody specific for CRMP-5, a previously unknown 62-kd neuronal cytoplasmic protein of the collapsin response-mediator family [14].
  • Autoantibodies produced against member(s) of this family by patients with paraneoplastic neurological diseases have made it possible to clone a fifth human Ulip/CRMP and characterize its cellular and anatomical distribution in developing brain [15].

Analytical, diagnostic and therapeutic context of CRMP1

  • Four members of this gene family, DRP-1, -2, -3 and -4, are expressed mainly in the fetal and neonatal brains of mammals and chickens, and have been implicated as intracellular signal transducers in the development of the nervous system [16].
  • We confirmed the differential expression of CRMP-1 with northern and western blot analyses [3].
  • 1. Sequence analysis revealed that the human CRMP-1 gene consists of 14 exons [17].


  1. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. Sivakumaran, T.A., Lesperance, M.M. Int. J. Mol. Med. (2004) [Pubmed]
  2. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. Chang, C.C., Shih, J.Y., Jeng, Y.M., Su, J.L., Lin, B.Z., Chen, S.T., Chau, Y.P., Yang, P.C., Kuo, M.L. J. Natl. Cancer Inst. (2004) [Pubmed]
  3. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. Shih, J.Y., Yang, S.C., Hong, T.M., Yuan, A., Chen, J.J., Yu, C.J., Chang, Y.L., Lee, Y.C., Peck, K., Wu, C.W., Yang, P.C. J. Natl. Cancer Inst. (2001) [Pubmed]
  4. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. Weitzdoerfer, R., Fountoulakis, M., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
  5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksöz, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H., Wanker, E.E. Cell (2005) [Pubmed]
  6. Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Goshima, Y., Nakamura, F., Strittmatter, P., Strittmatter, S.M. Nature (1995) [Pubmed]
  7. Functions of semaphorins in axon guidance and neuronal regeneration. Goshima, Y., Sasaki, Y., Nakayama, T., Ito, T., Kimura, T. Jpn. J. Pharmacol. (2000) [Pubmed]
  8. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. Cole, A.R., Causeret, F., Yadirgi, G., Hastie, C.J., McLauchlan, H., McManus, E.J., Hernández, F., Eickholt, B.J., Nikolic, M., Sutherland, C. J. Biol. Chem. (2006) [Pubmed]
  9. Collapsin response mediator protein-1: a novel invasion-suppressor gene. Shih, J.Y., Lee, Y.C., Yang, S.C., Hong, T.M., Huang, C.Y., Yang, P.C. Clin. Exp. Metastasis (2003) [Pubmed]
  10. Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration. Yamashita, N., Uchida, Y., Ohshima, T., Hirai, S., Nakamura, F., Taniguchi, M., Mikoshiba, K., Honnorat, J., Kolattukudy, P., Thomasset, N., Takei, K., Takahashi, T., Goshima, Y. J. Neurosci. (2006) [Pubmed]
  11. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. Deo, R.C., Schmidt, E.F., Elhabazi, A., Togashi, H., Burley, S.K., Strittmatter, S.M. EMBO J. (2004) [Pubmed]
  12. Fulminant autoimmune cortical encephalitis associated with thymoma treated with plasma exchange. Rickman, O.B., Parisi, J.E., Yu, Z., Lennon, V.A., Vernino, S. Mayo Clin. Proc. (2000) [Pubmed]
  13. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. Gu, Y., Ihara, Y. J. Biol. Chem. (2000) [Pubmed]
  14. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Yu, Z., Kryzer, T.J., Griesmann, G.E., Kim, K., Benarroch, E.E., Lennon, V.A. Ann. Neurol. (2001) [Pubmed]
  15. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. Ricard, D., Rogemond, V., Charrier, E., Aguera, M., Bagnard, D., Belin, M.F., Thomasset, N., Honnorat, J. J. Neurosci. (2001) [Pubmed]
  16. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. Kitamura, K., Takayama, M., Hamajima, N., Nakanishi, M., Sasaki, M., Endo, Y., Takemoto, T., Kimura, H., Iwaki, M., Nonaka, M. DNA Res. (1999) [Pubmed]
  17. Genomic organization and localization of the human CRMP-1 gene. Torres, R., Polymeropoulos, M.H. DNA Res. (1998) [Pubmed]
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