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Gene Review

Dpysl3  -  dihydropyrimidinase-like 3

Rattus norvegicus

Synonyms: CRMP-4, Collapsin response mediator protein 4, Crmp4, DRP-3, Dihydropyrimidinase-related protein 3, ...
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Disease relevance of Dpysl3


High impact information on Dpysl3

  • However, the growth cone collapse-inducing protein Sema3A increases Cdk5 activity and promotes phosphorylation of CRMP2 (but not CRMP4) [5].
  • Here, we report that a monoclonal antibody against chondroitin sulfate-binding proteins from neonatal rat brain recognizes collapsin response mediator protein-4 (CRMP-4), which belongs to a family of proteins involved in collapsin/semaphorin 3A signaling [6].
  • Overexpression of CRMP-4 inhibited the migration of B35 neuroblastoma cells, while knockdown of CRMP-4 enhanced cell migration and disturbed rib-like actin-structures in lamellipodia [1].
  • These findings suggest a specific regulatory role of CRMP-4 towards the actin cytoskeleton which may by be relevant for growth cone collapse [1].
  • In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa [2].

Biological context of Dpysl3


Anatomical context of Dpysl3

  • Here, we show that CRMP-4 co-localizes with F-actin in regular rib-like structures within lamellipodia of B35 neuroblastoma cells [1].
  • From DRP 3 onwards, CNTFRalpha mRNA appeared in photoreceptor cells located in the outer part of the outer nuclear layer [8].
  • The functional relevance of this N-terminal domain is demonstrated by the finding that overexpression of TUC-4b, but not TUC-4a, results in increased neurite length and branching [7].
  • TUC-4b is localized to SV2 (synaptic vesicle protein 2)-positive vesicles in the central domain of the growth cone, suggesting a potential role in growth cone vesicle transport [7].
  • RESULTS: CRMP-4, a marker of immature neuron, could be expressed in the ipsilateral striatum and cerebral cortex at 1st and 2nd week after the ischemia-reperfusion; nestin, a marker of neural stem cell, occurred in above regions from several hours to 2 weeks [4].

Associations of Dpysl3 with chemical compounds


Other interactions of Dpysl3

  • Collectively, these studies demonstrate for the first time that DPYSL3 is a calpain substrate [2].
  • Significant higher CRMP-2 protein but not CRMP-4 protein was found in the hypothyroid rats [9].
  • Furthermore, TUC-4b interacts with the SH3A (Src homology 3A) domain of intersectin, an endocytic-exocytic adaptor protein [7].

Analytical, diagnostic and therapeutic context of Dpysl3


  1. Collapsin response mediator protein-4 regulates F-actin bundling. Rosslenbroich, V., Dai, L., Baader, S.L., Noegel, A.A., Gieselmann, V., Kappler, J. Exp. Cell Res. (2005) [Pubmed]
  2. Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. Kowara, R., Chen, Q., Milliken, M., Chakravarthy, B. J. Neurochem. (2005) [Pubmed]
  3. Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Kee, N.J., Preston, E., Wojtowicz, J.M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2001) [Pubmed]
  4. Induction of CRMP-4 in striatum of adult rat after transient brain ischemia. Liu, P.C., Yang, Z.J., Qiu, M.H., Zhang, L.M., Sun, F.Y. Acta Pharmacol. Sin. (2003) [Pubmed]
  5. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. Cole, A.R., Causeret, F., Yadirgi, G., Hastie, C.J., McLauchlan, H., McManus, E.J., Hernández, F., Eickholt, B.J., Nikolic, M., Sutherland, C. J. Biol. Chem. (2006) [Pubmed]
  6. Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate. Franken, S., Junghans, U., Rosslenbroich, V., Baader, S.L., Hoffmann, R., Gieselmann, V., Viebahn, C., Kappler, J. J. Biol. Chem. (2003) [Pubmed]
  7. TUC-4b, a novel TUC family variant, regulates neurite outgrowth and associates with vesicles in the growth cone. Quinn, C.C., Chen, E., Kinjo, T.G., Kelly, G., Bell, A.W., Elliott, R.C., McPherson, P.S., Hockfield, S. J. Neurosci. (2003) [Pubmed]
  8. Increased expression of ciliary neurotrophic factor receptor alpha mRNA in the ischemic rat retina. Ju, W.K., Lee, M.Y., Hofmann, H.D., Kirsch, M., Oh, S.J., Chung, J.W., Chun, M.H. Neurosci. Lett. (2000) [Pubmed]
  9. Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus. Wong, C.C., Leung, M.S. Mol. Cell. Endocrinol. (2001) [Pubmed]
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