Disease relevance of Pou2f3

• Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice [1].

High impact information on Pou2f3

• A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression [2].
• This suggests that Skn-1a/i and Tst-1 serve redundant functions in epidermis [3].
• Analysis of Skn-1a/i gene-deleted mice reveals that the Skn-1a/i gene modulates the pattern of expression of the terminal differentiation marker loricrin and inhibits expression of genes encoding markers of the epidermal keratinocyte wounding response [3].
• Therefore, at least two POU domain genes, Skn-1a/i and Tst-1, serve both distinct and overlapping functions to regulate differentiation of epidermal keratinocytes during normal development and wound healing [3].
• IL-12 Instructs Skin Homing of Human Th2 Cells [4].

Biological context of Pou2f3

• These results suggest that Epoc-1 might be one of the developmental regulators which controls epidermal development and thymic organogenesis [5].
• In order to clarify the roles of POU-domain transcription factors in cell differentiation, we cloned a novel POU family gene, Epoc-1, from a murine thymus cDNA library [5].
• Functions of the Peroxisome Proliferator-Activated Receptor (PPAR) alpha and beta in Skin Homeostasis, Epithelial Repair, and Morphogenesis [6].
• IL-4 Suppresses UVB-induced Apoptosis in Skin [7].
• IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice [8].

Anatomical context of Pou2f3

• Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells [5].
• Epoc-1 was found to be expressed in skin, thymus, stomach and testis [5].
• In situ hybridization experiments and RNase protection assays indicated that Epoc-1 is expressed in the epidermal basal cells of the skin, which contain stem cells unipotent for keratinocyte differentiation and in thymic stromal elements [5].
• RESULTS: Skin Infiltration by eosinophils and expression of mRNA encoding the TH2 cytokines IL-4 and IL-5 in OVA-sensitized skin sites was impaired in C3-/- mice [9].
• METHODS: Skin was harvested from lower limbs of patients during elective surgery, placed in containers with anhydric salt powder, and kept at 22 degrees C for 3 to 12 weeks [10].

Analytical, diagnostic and therapeutic context of Pou2f3

• Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer [11].

References