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Gene Review

Pou2f3  -  POU domain, class 2, transcription factor 3

Mus musculus

Synonyms: Epoc-1, Epoc1, OTF-11, Oct-11, Oct-11a, ...
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Disease relevance of Pou2f3


High impact information on Pou2f3

  • A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression [2].
  • This suggests that Skn-1a/i and Tst-1 serve redundant functions in epidermis [3].
  • Analysis of Skn-1a/i gene-deleted mice reveals that the Skn-1a/i gene modulates the pattern of expression of the terminal differentiation marker loricrin and inhibits expression of genes encoding markers of the epidermal keratinocyte wounding response [3].
  • Therefore, at least two POU domain genes, Skn-1a/i and Tst-1, serve both distinct and overlapping functions to regulate differentiation of epidermal keratinocytes during normal development and wound healing [3].
  • IL-12 Instructs Skin Homing of Human Th2 Cells [4].

Biological context of Pou2f3


Anatomical context of Pou2f3

  • Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells [5].
  • Epoc-1 was found to be expressed in skin, thymus, stomach and testis [5].
  • In situ hybridization experiments and RNase protection assays indicated that Epoc-1 is expressed in the epidermal basal cells of the skin, which contain stem cells unipotent for keratinocyte differentiation and in thymic stromal elements [5].
  • RESULTS: Skin Infiltration by eosinophils and expression of mRNA encoding the TH2 cytokines IL-4 and IL-5 in OVA-sensitized skin sites was impaired in C3-/- mice [9].
  • METHODS: Skin was harvested from lower limbs of patients during elective surgery, placed in containers with anhydric salt powder, and kept at 22 degrees C for 3 to 12 weeks [10].

Analytical, diagnostic and therapeutic context of Pou2f3


  1. Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice. Kakurai, M., Monteforte, R., Suto, H., Tsai, M., Nakae, S., Galli, S.J. Am. J. Pathol. (2006) [Pubmed]
  2. Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis. Andersen, B., Schonemann, M.D., Flynn, S.E., Pearse, R.V., Singh, H., Rosenfeld, M.G. Science (1993) [Pubmed]
  3. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. Andersen, B., Weinberg, W.C., Rennekampff, O., McEvilly, R.J., Bermingham, J.R., Hooshmand, F., Vasilyev, V., Hansbrough, J.F., Pittelkow, M.R., Yuspa, S.H., Rosenfeld, M.G. Genes Dev. (1997) [Pubmed]
  4. IL-12 Instructs Skin Homing of Human Th2 Cells. Biedermann, T., Lametschwandtner, G., Tangemann, K., Kund, J., Hinteregger, S., Carballido-Perrig, N., Rot, A., Schwärzler, C., Carballido, J.M. J. Immunol. (2006) [Pubmed]
  5. Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells. Yukawa, K., Yasui, T., Yamamoto, A., Shiku, H., Kishimoto, T., Kikutani, H. Gene (1993) [Pubmed]
  6. Functions of the Peroxisome Proliferator-Activated Receptor (PPAR) alpha and beta in Skin Homeostasis, Epithelial Repair, and Morphogenesis. Icre, G., Wahli, W., Michalik, L. J. Invest. Dermatol. (2006) [Pubmed]
  7. IL-4 Suppresses UVB-induced Apoptosis in Skin. Hwang, H., Choi, S.Y., Kim, T.Y. J. Biochem. Mol. Biol. (2007) [Pubmed]
  8. IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice. Lee, J.H., Ha, J., Kim, S.H., Kim, S.J. J. Korean Med. Sci. (2006) [Pubmed]
  9. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. Yalcindag, A., He, R., Laouini, D., Alenius, H., Carroll, M., Oettgen, H.C., Geha, R.S. J. Allergy Clin. Immunol. (2006) [Pubmed]
  10. Human skin preserved long-term in anhydric pulverized sodium chloride retains cell molecular structure and resumes function after transplantation. Olszewski, W.L., Moscicka, M., Zolich, D. Transplantation (2006) [Pubmed]
  11. Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer. Jans, J., Garinis, G.A., Schul, W., van Oudenaren, A., Moorhouse, M., Smid, M., Sert, Y.G., van der Velde, A., Rijksen, Y., de Gruijl, F.R., van der Spek, P.J., Yasui, A., Hoeijmakers, J.H., Leenen, P.J., van der Horst, G.T. Mol. Cell. Biol. (2006) [Pubmed]
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