Gene Review:
Lor - loricrin
Mus musculus
Synonyms:
AI036317, Loricrin, S77319
- Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. Suga, Y., Jarnik, M., Attar, P.S., Longley, M.A., Bundman, D., Steven, A.C., Koch, P.J., Roop, D.R. J. Cell Biol. (2000)
- Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. de Miranda, F.G., Vilar, J.C., Alves, I.A., Cavalcanti, S.C., Antoniolli, A.R. BMC Pharmacol. (2001)
- A critical role for I{kappa}B kinase {alpha} in the development of human and mouse squamous cell carcinomas. Liu, B., Park, E., Zhu, F., Bustos, T., Liu, J., Shen, J., Fischer, S.M., Hu, Y. Proc. Natl. Acad. Sci. U.S.A. (2006)
- An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Kim, E., Rundhaug, J.E., Benavides, F., Yang, P., Newman, R.A., Fischer, S.M. Oncogene (2005)
- Identification of a major keratinocyte cell envelope protein, loricrin. Mehrel, T., Hohl, D., Rothnagel, J.A., Longley, M.A., Bundman, D., Cheng, C., Lichti, U., Bisher, M.E., Steven, A.C., Steinert, P.M. Cell (1990)
- Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. Andersen, B., Weinberg, W.C., Rennekampff, O., McEvilly, R.J., Bermingham, J.R., Hooshmand, F., Vasilyev, V., Hansbrough, J.F., Pittelkow, M.R., Yuspa, S.H., Rosenfeld, M.G. Genes Dev. (1997)
- A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. Borkowski, T.A., Letterio, J.J., Mackall, C.L., Saitoh, A., Wang, X.J., Roop, D.R., Gress, R.E., Udey, M.C. J. Clin. Invest. (1997)
- Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. Koch, P.J., de Viragh, P.A., Scharer, E., Bundman, D., Longley, M.A., Bickenbach, J., Kawachi, Y., Suga, Y., Zhou, Z., Huber, M., Hohl, D., Kartasova, T., Jarnik, M., Steven, A.C., Roop, D.R. J. Cell Biol. (2000)
- Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes. Xu, X., Kawachi, Y., Nakamura, Y., Sakurai, H., Hirota, A., Banno, T., Takahashi, T., Roop, D.R., Otsuka, F. J. Invest. Dermatol. (2004)
- Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. Dlugosz, A.A., Yuspa, S.H. J. Cell Biol. (1993)
- Overexpression of human loricrin in transgenic mice produces a normal phenotype. Yoneda, K., Steinert, P.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. Bickenbach, J.R., Greer, J.M., Bundman, D.S., Rothnagel, J.A., Roop, D.R. J. Invest. Dermatol. (1995)
- Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3. Rothnagel, J.A., Longley, M.A., Bundman, D.S., Naylor, S.L., Lalley, P.A., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Roop, D.R. Genomics (1994)
- Spatial distributions of sulfur-rich proteins in cornifying epithelia. Leapman, R.D., Jarnik, M., Steven, A.C. J. Struct. Biol. (1997)
- Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. Schmuth, M., Schoonjans, K., Yu, Q.C., Fluhr, J.W., Crumrine, D., Hachem, J.P., Lau, P., Auwerx, J., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2002)
- Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes. Steven, A.C., Bisher, M.E., Roop, D.R., Steinert, P.M. J. Struct. Biol. (1990)
- The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. DiSepio, D., Jones, A., Longley, M.A., Bundman, D., Rothnagel, J.A., Roop, D.R. J. Biol. Chem. (1995)
- Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. Denning, M.F., Kazanietz, M.G., Blumberg, P.M., Yuspa, S.H. Cell Growth Differ. (1995)
- Isolation of a GC-rich cDNA identifying mRNA present in human epidermis and modulated by calcium and retinoic acid in cultured keratinocytes. Homology with murine loricrin mRNA. Magnaldo, T., Pommes, L., Asselineau, D., Darmon, M. Mol. Biol. Rep. (1990)
- Regulation of epidermal differentiation by a Distal-less homeodomain gene. Morasso, M.I., Markova, N.G., Sargent, T.D. J. Cell Biol. (1996)
- Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro. Li, L., Tucker, R.W., Hennings, H., Yuspa, S.H. J. Cell. Physiol. (1995)
- Mouse epidermal keratinocytes in three-dimensional organotypic coculture with dermal fibroblasts form a stratified sheet resembling skin. Ikuta, S., Sekino, N., Hara, T., Saito, Y., Chida, K. Biosci. Biotechnol. Biochem. (2006)
- Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. Komuves, L., Oda, Y., Tu, C.L., Chang, W.H., Ho-Pao, C.L., Mauro, T., Bikle, D.D. J. Cell. Physiol. (2002)
- Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes. Lueders, K.K., Elliott, R.W., Marenholz, I., Mischke, D., DuPree, M., Hamer, D. Mamm. Genome (1999)
- Modulations in epidermal calcium regulate the expression of differentiation-specific markers. Elias, P.M., Ahn, S.K., Denda, M., Brown, B.E., Crumrine, D., Kimutai, L.K., Kömüves, L., Lee, S.H., Feingold, K.R. J. Invest. Dermatol. (2002)
- Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Kim, S., Hong, I., Hwang, J.S., Choi, J.K., Rho, H.S., Kim, D.H., Chang, I., Lee, S.H., Lee, M.O., Hwang, J.S. Mol. Med. (2006)
- In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes accelerated terminal differentiation in fetal mouse skin. Loertscher, J.A., Lin, T.M., Peterson, R.E., Allen-Hoffmann, B.L. Toxicol. Sci. (2002)