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Gene Review

EPHA2  -  EPH receptor A2

Homo sapiens

Synonyms: ARCC2, CTPA, CTPP1, CTRCT6, ECK, ...
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Disease relevance of EPHA2


High impact information on EPHA2


Chemical compound and disease context of EPHA2


Biological context of EPHA2


Anatomical context of EPHA2


Associations of EPHA2 with chemical compounds

  • PURPOSE: EphA2 (epithelial cell kinase) is a transmembrane receptor tyrosine kinase that has been implicated in oncogenesis [12].
  • Normal duct luminal cells showed a different CK profile, reacting consistently with ECK, a polyclonal antibody to epidermal prekeratin (CK 3,6), and monoclonal antibodies 4.62, PKK1 and 8.60 [13].
  • A Novel Mechanism for p53 to Regulate Its Target Gene ECK in Signaling Apoptosis [10].

Physical interactions of EPHA2

  • EPHA2 interacted with both Src and LMW-PTP, and the interactions increased in EPHA2-overexpressing cells [14].

Other interactions of EPHA2

  • Expression of two of them, EFNA1 ligand and its receptor, EPHA2, has been proposed to contribute to tumor-induced neovascularization [1].
  • Microvessel counts (MVCs) after immunostaining for CD34 were significantly correlated (r = 0.343, P = 0.037) with overexpression of EPHA2 [1].
  • Epithelial cell kinase (ECK) is a receptor protein tyrosine kinase, the role of which in melanoma biology is unclear [2].
  • ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers [8].
  • Additional PCR screening of a regional screening panel for chromosome 1p indicated that ECK is localized to 1p36, distal to FUCA1 [8].

Analytical, diagnostic and therapeutic context of EPHA2


  1. Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Kataoka, H., Igarashi, H., Kanamori, M., Ihara, M., Wang, J.D., Wang, Y.J., Li, Z.Y., Shimamura, T., Kobayashi, T., Maruyama, K., Nakamura, T., Arai, H., Kajimura, M., Hanai, H., Tanaka, M., Sugimura, H. Cancer Sci. (2004) [Pubmed]
  2. Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression. Easty, D.J., Guthrie, B.A., Maung, K., Farr, C.J., Lindberg, R.A., Toso, R.J., Herlyn, M., Bennett, D.C. Cancer Res. (1995) [Pubmed]
  3. EPHA2/EFNA1 expression in human gastric cancer. Nakamura, R., Kataoka, H., Sato, N., Kanamori, M., Ihara, M., Igarashi, H., Ravshanov, S., Wang, Y.J., Li, Z.Y., Shimamura, T., Kobayashi, T., Konno, H., Shinmura, K., Tanaka, M., Sugimura, H. Cancer Sci. (2005) [Pubmed]
  4. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Bartley, T.D., Hunt, R.W., Welcher, A.A., Boyle, W.J., Parker, V.P., Lindberg, R.A., Lu, H.S., Colombero, A.M., Elliott, R.L., Guthrie, B.A. Nature (1994) [Pubmed]
  5. Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2). Hess, A.R., Seftor, E.A., Gardner, L.M., Carles-Kinch, K., Schneider, G.B., Seftor, R.E., Kinch, M.S., Hendrix, M.J. Cancer Res. (2001) [Pubmed]
  6. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Zelinski, D.P., Zantek, N.D., Stewart, J.C., Irizarry, A.R., Kinch, M.S. Cancer Res. (2001) [Pubmed]
  7. Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status. Mudali, S.V., Fu, B., Lakkur, S.S., Luo, M., Embuscado, E.E., Iacobuzio-Donahue, C.A. Clin. Exp. Metastasis (2006) [Pubmed]
  8. ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Sulman, E.P., Tang, X.X., Allen, C., Biegel, J.A., Pleasure, D.E., Brodeur, G.M., Ikegaki, N. Genomics (1997) [Pubmed]
  9. Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function. Rosenberg, I.M., Göke, M., Kanai, M., Reinecker, H.C., Podolsky, D.K. Am. J. Physiol. (1997) [Pubmed]
  10. A Novel Mechanism for p53 to Regulate Its Target Gene ECK in Signaling Apoptosis. Jin, Y.J., Wang, J., Qiao, C., Hei, T.K., Brandt-Rauf, P.W., Yin, Y. Mol. Cancer Res. (2006) [Pubmed]
  11. Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis. Takahashi, H., Ikeda, T. Oncogene (1995) [Pubmed]
  12. EphA2 expression is associated with aggressive features in ovarian carcinoma. Thaker, P.H., Deavers, M., Celestino, J., Thornton, A., Fletcher, M.S., Landen, C.N., Kinch, M.S., Kiener, P.A., Sood, A.K. Clin. Cancer Res. (2004) [Pubmed]
  13. Intermediate filament expression in normal parotid glands and pleomorphic adenomas. Burns, B.F., Dardick, I., Parks, W.R. Virchows Archiv. A, Pathological anatomy and histopathology. (1988) [Pubmed]
  14. Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. Fang, W.B., Ireton, R.C., Zhuang, G., Takahashi, T., Reynolds, A., Chen, J. J. Cell. Sci. (2008) [Pubmed]
  15. Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Easty, D.J., Herlyn, M., Bennett, D.C. Int. J. Cancer (1995) [Pubmed]
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