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Gene Review

Mif  -  macrophage migration inhibitory factor

Mus musculus

Synonyms: DER6, Delayed early response protein 6, GIF, Glif, Glycosylation-inhibiting factor, ...
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Disease relevance of Mif


High impact information on Mif


Chemical compound and disease context of Mif


Biological context of Mif


Anatomical context of Mif


Associations of Mif with chemical compounds


Regulatory relationships of Mif


Other interactions of Mif


Analytical, diagnostic and therapeutic context of Mif


  1. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Wilson, J.M., Coletta, P.L., Cuthbert, R.J., Scott, N., MacLennan, K., Hawcroft, G., Leng, L., Lubetsky, J.B., Jin, K.K., Lolis, E., Medina, F., Brieva, J.A., Poulsom, R., Markham, A.F., Bucala, R., Hull, M.A. Gastroenterology (2005) [Pubmed]
  2. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Cvetkovic, I., Al-Abed, Y., Miljkovic, D., Maksimovic-Ivanic, D., Roth, J., Bacher, M., Lan, H.Y., Nicoletti, F., Stosic-Grujicic, S. Endocrinology (2005) [Pubmed]
  3. Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. Koebernick, H., Grode, L., David, J.R., Rohde, W., Rolph, M.S., Mittrücker, H.W., Kaufmann, S.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Effects of dexamethasone on macrophage migration inhibitory factor production in sepsis. Bruhn, A., Verdant, C., Vercruysse, V., Su, F., Vray, B., Vincent, J.L. Shock (2006) [Pubmed]
  5. The role of macrophage migration inhibitory factor in lethal Listeria monocytogenes infection in mice. Sashinami, H., Sakuraba, H., Ishiguro, Y., Munakata, A., Nishihira, J., Nakane, A. Microb. Pathog. (2006) [Pubmed]
  6. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Roger, T., David, J., Glauser, M.P., Calandra, T. Nature (2001) [Pubmed]
  7. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Calandra, T., Echtenacher, B., Roy, D.L., Pugin, J., Metz, C.N., Hültner, L., Heumann, D., Männel, D., Bucala, R., Glauser, M.P. Nat. Med. (2000) [Pubmed]
  8. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Bernhagen, J., Calandra, T., Mitchell, R.A., Martin, S.B., Tracey, K.J., Voelter, W., Manogue, K.R., Cerami, A., Bucala, R. Nature (1993) [Pubmed]
  9. HIF1{alpha} delays premature senescence through the activation of MIF. Welford, S.M., Bedogni, B., Gradin, K., Poellinger, L., Broome Powell, M., Giaccia, A.J. Genes Dev. (2006) [Pubmed]
  10. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Petrenko, O., Moll, U.M. Mol. Cell (2005) [Pubmed]
  11. Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Ohkawara, T., Nishihira, J., Takeda, H., Hige, S., Kato, M., Sugiyama, T., Iwanaga, T., Nakamura, H., Mizue, Y., Asaka, M. Gastroenterology (2002) [Pubmed]
  12. Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice. Shimizu, T., Abe, R., Nishihira, J., Shibaki, A., Watanabe, H., Nakayama, T., Taniguchi, M., Ishibashi, T., Shimizu, H. Eur. J. Immunol. (2003) [Pubmed]
  13. Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. Tanino, Y., Makita, H., Miyamoto, K., Betsuyaku, T., Ohtsuka, Y., Nishihira, J., Nishimura, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  14. Lens epithelial cell mRNA. III. Elevated expression of macrophage migration inhibitory factor mRNA in galactose cataracts. Wen, Y., Li, G.W., Bekhor, I. Curr. Eye Res. (1996) [Pubmed]
  15. Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes. Bozza, M., Kolakowski, L.F., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., David, J.R., Gerard, C. Genomics (1995) [Pubmed]
  16. Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening. Korshunov, V.A., Nikonenko, T.A., Tkachuk, V.A., Brooks, A., Berk, B.C. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  17. Blockade of macrophage migration inhibitory factor (MIF) in Schistosoma japonicum-infected mice results in an increased adult worm burden and reduced fecundity. Stavitsky, A.B., Metz, C., Liu, S., Xianli, J., Bucala, R. Parasite Immunol. (2003) [Pubmed]
  18. Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Mitchell, R.A., Liao, H., Chesney, J., Fingerle-Rowson, G., Baugh, J., David, J., Bucala, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  19. Identification of macrophage migration inhibitory factor in adipose tissue and its induction by tumor necrosis factor-alpha. Hirokawa, J., Sakaue, S., Tagami, S., Kawakami, Y., Sakai, M., Nishi, S., Nishihira, J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  20. Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes. Hirokawa, J., Sakaue, S., Furuya, Y., Ishii, J., Hasegawa, A., Tagami, S., Kawakami, Y., Sakai, M., Nishi, S., Nishihira, J. J. Biochem. (1998) [Pubmed]
  21. Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium. Maaser, C., Eckmann, L., Paesold, G., Kim, H.S., Kagnoff, M.F. Gastroenterology (2002) [Pubmed]
  22. Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. Tan, T.H., Edgerton, S.A., Kumari, R., McAlister, M.S., Roe, S.M., Nagl, S., Pearl, L.H., Selkirk, M.E., Bianco, A.E., Totty, N.F., Engwerda, C., Gray, C.A., Meyer, D.J., Rowe, S.M. Biochem. J. (2001) [Pubmed]
  23. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Benigni, F., Atsumi, T., Calandra, T., Metz, C., Echtenacher, B., Peng, T., Bucala, R. J. Clin. Invest. (2000) [Pubmed]
  24. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. Ashcroft, G.S., Mills, S.J., Lei, K., Gibbons, L., Jeong, M.J., Taniguchi, M., Burow, M., Horan, M.A., Wahl, S.M., Nakayama, T. J. Clin. Invest. (2003) [Pubmed]
  25. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Senter, P.D., Al-Abed, Y., Metz, C.N., Benigni, F., Mitchell, R.A., Chesney, J., Han, J., Gartner, C.G., Nelson, S.D., Todaro, G.J., Bucala, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Macrophage Migration Inhibitory Factor Induces Macrophage Recruitment via CC Chemokine Ligand 2. Gregory, J.L., Morand, E.F., McKeown, S.J., Ralph, J.A., Hall, P., Yang, Y.H., McColl, S.R., Hickey, M.J. J. Immunol. (2006) [Pubmed]
  27. Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation. Petrenko, O., Fingerle-Rowson, G., Peng, T., Mitchell, R.A., Metz, C.N. J. Biol. Chem. (2003) [Pubmed]
  28. Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway. Sun, B., Nishihira, J., Yoshiki, T., Kondo, M., Sato, Y., Sasaki, F., Todo, S. Clin. Cancer Res. (2005) [Pubmed]
  29. Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice. Ohkawara, T., Takeda, H., Nishihira, J., Miyashita, K., Nihiwaki, M., Ishiguro, Y., Takeda, K., Akira, S., Iwanaga, T., Sugiyama, T., Asaka, M. Clin. Exp. Immunol. (2005) [Pubmed]
  30. Impaired DNA damage checkpoint response in MIF-deficient mice. Nemajerova, A., Mena, P., Fingerle-Rowson, G., Moll, U.M., Petrenko, O. EMBO J. (2007) [Pubmed]
  31. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Fingerle-Rowson, G., Petrenko, O., Metz, C.N., Forsthuber, T.G., Mitchell, R., Huss, R., Moll, U., Müller, W., Bucala, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  32. Do interleukin-6 and macrophage-migration inhibitory factor play a role during sex-associated susceptibility in murine cysticercosis? Morales-Montor, J., Baig, S., Kabbani, A., Damian, R.T. Parasitol. Res. (2002) [Pubmed]
  33. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Pan, J.H., Sukhova, G.K., Yang, J.T., Wang, B., Xie, T., Fu, H., Zhang, Y., Satoskar, A.R., David, J.R., Metz, C.N., Bucala, R., Fang, K., Simon, D.I., Chapman, H.A., Libby, P., Shi, G.P. Circulation (2004) [Pubmed]
  34. Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. Mikayama, T., Nakano, T., Gomi, H., Nakagawa, Y., Liu, Y.C., Sato, M., Iwamatsu, A., Ishii, Y., Weiser, W.Y., Ishizaka, K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  35. Cardiac allograft rejection in the absence of macrophage migration inhibitory factor. Demir, Y., Chen, Y., Metz, C., Renz, H., Heeger, P.S. Transplantation (2003) [Pubmed]
  36. Evidence for the presence of macrophage migration inhibitory factor in murine reproductive organs and early embryos. Suzuki, H., Kanagawa, H., Nishihira, J. Immunol. Lett. (1996) [Pubmed]
  37. Antigen-binding glycosylation inhibiting factor from a human T-cell hybridoma specific for bee venom phospholipase A2. Gomi, H., Tagaya, Y., Nakano, T., Mikayama, T., Ishizaka, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  38. Biochemical characterization of murine glycosylation-inhibiting factor. Tagaya, Y., Mori, A., Ishizaka, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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