Gene Review:
Ssb - Sjogren syndrome antigen B
Mus musculus
Synonyms:
La autoantigen homolog, La protein, La ribonucleoprotein, Lupus La protein homolog, SS-B, ...
- The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Park, J.M., Kohn, M.J., Bruinsma, M.W., Vech, C., Intine, R.V., Fuhrmann, S., Grinberg, A., Mukherjee, I., Love, P.E., Ko, M.S., DePamphilis, M.L., Maraia, R.J. Mol. Cell. Biol. (2006)
- Subcellular redistribution of la/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: a clue to the pathogenesis of congenital heart block. Tran, H.B., Ohlsson, M., Beroukas, D., Hiscock, J., Bradley, J., Buyon, J.P., Gordon, T.P. Arthritis Rheum. (2002)
- Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Sobel, S.G., Wolin, S.L. Mol. Biol. Cell (1999)
- Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. Casciola-Rosen, L.A., Anhalt, G., Rosen, A. J. Exp. Med. (1994)
- Anti-La/SSB antibodies transported across the placenta bind apoptotic cells in fetal organs targeted in neonatal lupus. Tran, H.B., Macardle, P.J., Hiscock, J., Cavill, D., Bradley, J., Buyon, J.P., Gordon, T.P. Arthritis Rheum. (2002)
- The role of anti-idiotypic antibodies in the induction of experimental systemic lupus erythematosus in mice. Mendlovic, S., Fricke, H., Shoenfeld, Y., Mozes, E. Eur. J. Immunol. (1989)
- Characterization of the autoantigen La as a nucleic acid-dependent ATPase/dATPase with melting properties. Bachmann, M., Pfeifer, K., Schröder, H.C., Müller, W.E. Cell (1990)
- Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren's syndrome. Harley, J.B., Reichlin, M., Arnett, F.C., Alexander, E.L., Bias, W.B., Provost, T.T. Science (1986)
- Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice. Reynolds, P., Gordon, T.P., Purcell, A.W., Jackson, D.C., McCluskey, J. J. Exp. Med. (1996)
- Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity. Gordon, T.P., Kinoshita, G., Cavill, D., Keech, C., Farris, A., Kaufman, K., McCluskey, J., Purcell, A. Scand. J. Immunol. (2002)
- Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Topfer, F., Gordon, T., McCluskey, J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Induction of autoimmunity by multivalent immunodominant and subdominant T cell determinants of La (SS-B). Farris, A.D., Brown, L., Reynolds, P., Harley, J.B., James, J.A., Scofield, R.H., McCluskey, J., Gordon, T.P. J. Immunol. (1999)
- The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro. Gottlieb, E., Steitz, J.A. EMBO J. (1989)
- Isofocusing of antigenic small nuclear ribonucleoproteins. II. Preparative isolation. Schrier, W.H., Feinbaum, R., Okarma, T.B. Anal. Biochem. (1985)
- The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Pyun, E.H., Pisetsky, D.S., Gilkeson, G.S. J. Autoimmun. (1993)
- Cross-reactivity of antibodies immunoadsorbed to laminin with recombinant human La (SS-B) protein. Chang, S.H., Huh, M.S., Kim, H.R., Kim, I.S., Kim, S., Lee, J.S., Semsei, I., Grölz, D., Bachmann, M. J. Autoimmun. (1998)
- Tissue uptake and catabolic studies of 125I SS-B (La) injected into mice. Schrieber, L., Melsom, R.D., Venables, P.J., Maini, R.N. Clin. Immunol. Immunopathol. (1984)
- La autoantigen is cleaved in the COOH terminus and loses the nuclear localization signal during apoptosis. Ayukawa, K., Taniguchi, S., Masumoto, J., Hashimoto, S., Sarvotham, H., Hara, A., Aoyama, T., Sagara, J. J. Biol. Chem. (2000)
- In vitro modification of solid phase multiple antigenic peptides/autoantigens with 4-hydroxy-2-nonenal (HNE) provide ideal substrates for detection of anti-HNE antibodies and peptide antioxidants. Kurien, B.T., Hal Scofield, R. J. Immunol. Methods (2005)
- Identification of a human-specific epitope in a conserved region of the La/SS-B autoantigen. Weng, Y.M., McNeilage, J., Topfer, F., McCluskey, J., Gordon, T. J. Clin. Invest. (1993)
- Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells. Hendrick, J.P., Wolin, S.L., Rinke, J., Lerner, M.R., Steitz, J.A. Mol. Cell. Biol. (1981)
- A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein. Goodier, J.L., Fan, H., Maraia, R.J. Mol. Cell. Biol. (1997)
- Fine specificities of autoantibodies directed against the Ro, La, Sm, RNP, and Jo-1 proteins defined by two-dimensional gel electrophoresis and immunoblotting. Elkon, K.B., Jankowski, P.W. J. Immunol. (1985)