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Chemical Compound Review

SureCN157645     [5-(2,4-dioxopyrimidin-1-yl)- 3,4-dihydroxy...

Synonyms: AG-E-89886, AG-K-92419, U1752_SIGMA, CHEBI:117716, KST-1B6160, ...
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Disease relevance of UMP


High impact information on UMP


Chemical compound and disease context of UMP


Biological context of UMP


Anatomical context of UMP

  • Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats [18].
  • The incorporation rates of labeled orotic acid into poly(A)-containing mRNA isolated from polysomes are represented as the specific radioactivity (SR) (dpm/mg RNA) and the relative specific radioactivity (RSR) (dpm/mg RNA/dpm/mumoles of acid soluble uridine-5'-monophosphate (UMP] [19].
  • The data suggest that Kupffer cells do not contribute to GalN-induced liver injury as a result of uridylate trapping [20].
  • Both phosphate and uridylate derivates were also observed as main metabolites in the heart, lung, spleen and small intestine [21].
  • After a localized crush lesion of the right sciatic nerve, rats were given nucleotides daily at a dosage of 3.0 mg/kg body wt uridine monophosphate (UM), 2.5 mg/kg body wt cytidine monophosphate (CMP) or 3.0 plus 2.5 mg/kg body wt UMP plus CMP, respectively [22].

Associations of UMP with other chemical compounds


Gene context of UMP

  • AUF1/heterogeneous nuclear ribonucleoprotein D (hnRNPD) binds to adenylate uridylate-rich elements contained in the 3' untranslated region of many short-lived mRNAs [15].
  • Although RRM 3 (of either TIA-1 or TIAR) does not interact with the uridylate-rich sequences selected by the full-length proteins, it is a bona fide RNA binding domain capable of affinity-precipitating a population of cellular RNAs ranging in size from 0.5 to 5 kilobases [27].
  • The ecto-5'-nucleotidase readily hydrolyzed 5'-AMP and 5'-UMP [28].
  • Additional methods including analysis of oligonucleotides following chemical blocking of uridylate residues with CMCT and analysis of products of incomplete enzymatic digestion are also discussed [29].
  • The few transcripts synthesized in the absence of La have fewer uridylate residues at their 3' ends than those made in its presence [30].

Analytical, diagnostic and therapeutic context of UMP


  1. Interplay of two uridylate-specific RNA binding sites in the translocation of poly(A) polymerase from vaccinia virus. Deng, L., Gershon, P.D. EMBO J. (1997) [Pubmed]
  2. The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. Wilusz, J., Feig, D.I., Shenk, T. Mol. Cell. Biol. (1988) [Pubmed]
  3. Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. Ohmstede, C.A., Langdon, S.D., Chae, C.B., Jones, M.E. J. Biol. Chem. (1986) [Pubmed]
  4. RNA recognition and cleavage by the SARS coronavirus endoribonuclease. Bhardwaj, K., Sun, J., Holzenburg, A., Guarino, L.A., Kao, C.C. J. Mol. Biol. (2006) [Pubmed]
  5. The 5'-terminal nucleotides of hepatitis A virus RNA, but not poliovirus RNA, are required for infectivity. Harmon, S.A., Richards, O.C., Summers, D.F., Ehrenfeld, E. J. Virol. (1991) [Pubmed]
  6. Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing. Seiwert, S.D., Heidmann, S., Stuart, K. Cell (1996) [Pubmed]
  7. RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA. Kable, M.L., Seiwert, S.D., Heidmann, S., Stuart, K. Science (1996) [Pubmed]
  8. Effects of D-glucosamine and 6-azauridine on nucleotide contents, 5-fluorouridine uptake, and cytotoxicity in TA3 mammary tumor cells. Holstege, A., Keppler, D. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. Uridylate-containing RNA sequences determine specificity for binding and polyadenylation by the catalytic subunit of vaccinia virus poly(A) polymerase. Gershon, P.D., Moss, B. EMBO J. (1993) [Pubmed]
  10. Characterisation of basic proteins from Spiroplasma melliferum using novel immobilised pH gradients. Cordwell, S.J., Basseal, D.J., Bjellqvist, B., Shaw, D.C., Humphery-Smith, I. Electrophoresis (1997) [Pubmed]
  11. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Krylova, I.B., Kachaeva, E.V., Rodionova, O.M., Negoda, A.E., Evdokimova, N.R., Balina, M.I., Sapronov, N.S., Mironova, G.D. Exp. Gerontol. (2006) [Pubmed]
  12. Potential for ambiguity in the interpretation of immunochemical studies on multienzymic proteins. The case of uridylate synthase. McClard, R.W., Jones, M.E. Biochim. Biophys. Acta (1982) [Pubmed]
  13. Novel pattern of editing regions in mitochondrial transcripts of the cryptobiid Trypanoplasma borreli. Lukes, J., Arts, G.J., van den Burg, J., de Haan, A., Opperdoes, F., Sloof, P., Benne, R. EMBO J. (1994) [Pubmed]
  14. An integrated computational and laboratory approach for selective amplification of mRNAs containing the adenylate uridylate-rich element consensus sequence. Khabar, K.S., Dhalla, M., Bakheet, T., Sy, C., al-Haj, L. Genome Res. (2002) [Pubmed]
  15. A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice. Gouble, A., Grazide, S., Meggetto, F., Mercier, P., Delsol, G., Morello, D. Cancer Res. (2002) [Pubmed]
  16. Trypanosoma brucei RNA editing. A full round of uridylate insertional editing in vitro mediated by endonuclease and RNA ligase. Piller, K.J., Rusché, L.N., Sollner-Webb, B. J. Biol. Chem. (1996) [Pubmed]
  17. Disruption of base-paired U4.U6 small nuclear RNAs induced by mammalian heterogeneous nuclear ribonucleoprotein C protein. Forné, T., Rossi, F., Labourier, E., Antoine, E., Cathala, G., Brunel, C., Tazi, J. J. Biol. Chem. (1995) [Pubmed]
  18. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Wang, L., Pooler, A.M., Albrecht, M.A., Wurtman, R.J. J. Mol. Neurosci. (2005) [Pubmed]
  19. Alterations in polyadenylic acid-containing messenger RNA synthesis of brain polysomes after seizures of seizure-susceptible E1 mice. Yamagami, S., Onishi, H., Kawakita, Y. Acta neurologica Scandinavica. (1989) [Pubmed]
  20. Effect of d-galactosamine administration on nucleotide and protein metabolism in isolated rat Kupffer cells. Hofmann, F., Wagle, S.R., Decker, K. Hoppe-Seyler's Z. Physiol. Chem. (1976) [Pubmed]
  21. Accumulation of 2-deoxy-2-[18F]fluoro-D-galactose in the liver by phosphate and uridylate trapping. Ishiwata, K., Ido, T., Imahori, Y., Yamaguchi, K., Fukuda, H., Tada, M., Matsuzawa, T. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. (1988) [Pubmed]
  22. Acceleration of nerve and muscle regeneration by administration of nucleotides--electroneurophysiological and morphometrical investigations. Wattig, B., Schalow, G., Madauss, M., Heydenreich, F., Warzok, R., Cervós-Navarro, J. Acta Histochem. Suppl. (1992) [Pubmed]
  23. Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes. Rathod, P.K., Reyes, P. J. Biol. Chem. (1983) [Pubmed]
  24. Determination of 5'-nucleotidase activity in human erythrocytes and plasma using high-performance liquid chromatography. Sakai, T., Yanagihara, S., Ushio, K. J. Chromatogr. (1982) [Pubmed]
  25. Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat. Wang, L., Albrecht, M.A., Wurtman, R.J. Brain Res. (2007) [Pubmed]
  26. Enzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae. Vorísek, J., Techniková, Z., Schwippel, J., Benoist, P. Yeast (2002) [Pubmed]
  27. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. Dember, L.M., Kim, N.D., Liu, K.Q., Anderson, P. J. Biol. Chem. (1996) [Pubmed]
  28. Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells. Stefanovic, V., Mandel, P., Rosenberg, A. J. Biol. Chem. (1976) [Pubmed]
  29. Approaches to sequence analysis of 125I-labeled RNA. Dickson, E., Pape, L.K., Robertson, H.D. Nucleic Acids Res. (1979) [Pubmed]
  30. The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro. Gottlieb, E., Steitz, J.A. EMBO J. (1989) [Pubmed]
  31. Roles for ligases in the RNA editing complex of Trypanosoma brucei: band IV is needed for U-deletion and RNA repair. Huang, C.E., Cruz-Reyes, J., Zhelonkina, A.G., O'Hearn, S., Wirtz, E., Sollner-Webb, B. EMBO J. (2001) [Pubmed]
  32. Impaired gametogenesis in mice that overexpress the RNA-binding protein HuR. Levadoux-Martin, M., Gouble, A., Jégou, B., Vallet-Erdtmann, V., Auriol, J., Mercier, P., Morello, D. EMBO Rep. (2003) [Pubmed]
  33. New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. Xu, X., Zhai, Y., Sun, F., Lou, Z., Su, D., Xu, Y., Zhang, R., Joachimiak, A., Zhang, X.C., Bartlam, M., Rao, Z. J. Virol. (2006) [Pubmed]
  34. In vivo metabolism and UTP-depleting action of 2-deoxy-2-fluoro-D-galactose. Grün, B.R., Berger, U., Oberdorfer, F., Hull, W.E., Ostertag, H., Keppler, D. Adv. Enzyme Regul. (1990) [Pubmed]
  35. The rapid separation of orotate, orotidylate, and uridylate by thin-layer chromatography. Utility in the assay of orotate phosphoribosyltransferase and orotidylate decarboxylase. Reyes, P. Anal. Biochem. (1977) [Pubmed]
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