Gene Review:
FASN - fatty acid synthase
Homo sapiens
Synonyms:
FAS, Fatty acid synthase, OA-519, SDR27X1
- Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma. Shah, U.S., Dhir, R., Gollin, S.M., Chandran, U.R., Lewis, D., Acquafondata, M., Pflug, B.R. Hum. Pathol. (2006)
- Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Menendez, J.A., Vellon, L., Mehmi, I., Oza, B.P., Ropero, S., Colomer, R., Lupu, R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Feuk, L., Prince, J.A., Breen, G., Emahazion, T., Carothers, A., St Clair, D., Brookes, A.J. Hum. Genet. (2000)
- Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels : The Tromsø study. Jorde, R., Waterloo, K., Saleh, F., Haug, E., Svartberg, J. J. Neurol. (2006)
- Recovery from energy deficit in golden hamsters. Borer, K.T., Allen, E.R., Smalley, R.E., Lundell, L., Stockton, J. Am. J. Physiol. (1985)
- Characteristics of fathers who have children with fetal alcohol syndrome or incomplete fetal alcohol syndrome. Kvigne, V.L., Leondardson, G.R., Welty, T.K. South Dakota medicine : the journal of the South Dakota State Medical Association. (2006)
- Modular organization of genes required for complex polyketide biosynthesis. Donadio, S., Staver, M.J., McAlpine, J.B., Swanson, S.J., Katz, L. Science (1991)
- T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. Estaquier, J., Idziorek, T., Zou, W., Emilie, D., Farber, C.M., Bourez, J.M., Ameisen, J.C. J. Exp. Med. (1995)
- Food for thought: endocannabinoid modulation of lipogenesis. Lichtman, A.H., Cravatt, B.F. J. Clin. Invest. (2005)
- Expression of the progestin-induced fatty acid synthetase in benign mastopathies and breast cancer as measured by RNA in situ hybridization. Chalbos, D., Escot, C., Joyeux, C., Tissot-Carayon, M.J., Pages, A., Rochefort, H. J. Natl. Cancer Inst. (1990)
- Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Thupari, J.N., Pinn, M.L., Kuhajda, F.P. Biochem. Biophys. Res. Commun. (2001)
- Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling. Weng, M.S., Ho, C.T., Ho, Y.S., Lin, J.K. Toxicol. Appl. Pharmacol. (2007)
- A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Kovacs, P., Harper, I., Hanson, R.L., Infante, A.M., Bogardus, C., Tataranni, P.A., Baier, L.J. Diabetes (2004)
- Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Yang, Y.A., Morin, P.J., Han, W.F., Chen, T., Bornman, D.M., Gabrielson, E.W., Pizer, E.S. Exp. Cell Res. (2003)
- Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells. Menendez, J.A., Colomer, R., Lupu, R. Oncol. Rep. (2004)
- Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. López, M., Lelliott, C.J., Tovar, S., Kimber, W., Gallego, R., Virtue, S., Blount, M., Vázquez, M.J., Finer, N., Powles, T.J., O'Rahilly, S., Saha, A.K., Diéguez, C., Vidal-Puig, A.J. Diabetes (2006)
- Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9). Menendez, J.A., Lupu, R. Current pharmaceutical biotechnology (2006)
- Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Chajès, V., Cambot, M., Moreau, K., Lenoir, G.M., Joulin, V. Cancer Res. (2006)
- Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport. Field, F.J., Born, E., Murthy, S., Mathur, S.N. Biochem. J. (2002)
- In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. Menendez, J.A., Decker, J.P., Lupu, R. J. Cell. Biochem. (2005)
- Mapping of FASN and ACACA on two chicken microchromosomes disrupts the human 17q syntenic group well conserved in mammals. Pitel, F., Fillon, V., Heimel, C., Le Fur, N., el Khadir-Mounier, C., Douaire, M., Gellin, J., Vignal, A. Mamm. Genome (1998)
- Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. Xu, J., Nakamura, M.T., Cho, H.P., Clarke, S.D. J. Biol. Chem. (1999)
- Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene. Menendez, J.A., Vellon, L., Oza, B.P., Lupu, R. J. Cell. Biochem. (2005)
- Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Swinnen, J.V., Heemers, H., Deboel, L., Foufelle, F., Heyns, W., Verhoeven, G. Oncogene (2000)
- A homogeneous scintillation proximity assay for acetyl coenzyme A carboxylase coupled to fatty acid synthase. Seethala, R., Ma, Z., Golla, R., Cheng, D. Anal. Biochem. (2006)
- Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Weiss, L., Hoffmann, G.E., Schreiber, R., Andres, H., Fuchs, E., Körber, E., Kolb, H.J. Biol. Chem. Hoppe-Seyler (1986)
- Enzymatic reduction of phenylglyoxal and 2,3-butanedione, two commonly used arginine-modifying reagents, by the ketoacyl reductase domain of fatty acid synthase. Poulose, A.J., Kolattukudy, P.E. Int. J. Biochem. (1986)
- Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Yeh, C.W., Chen, W.J., Chiang, C.T., Lin-Shiau, S.Y., Lin, J.K. Pharmacogenomics J. (2003)
- Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Zhou, W., Simpson, P.J., McFadden, J.M., Townsend, C.A., Medghalchi, S.M., Vadlamudi, A., Pinn, M.L., Ronnett, G.V., Kuhajda, F.P. Cancer Res. (2003)
- Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. Menendez, J.A., Oza, B.P., Atlas, E., Verma, V.A., Mehmi, I., Lupu, R. Oncogene (2004)
- Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. Uddin, S., Siraj, A.K., Al-Rasheed, M., Ahmed, M., Bu, R., Myers, J.N., Al-Nuaim, A., Al-Sobhi, S., Al-Dayel, F., Bavi, P., Hussain, A.R., Al-Kuraya, K.S. J. Clin. Endocrinol. Metab. (2008)
- Quaternary structure of human fatty acid synthase by electron cryomicroscopy. Brink, J., Ludtke, S.J., Yang, C.Y., Gu, Z.W., Wakil, S.J., Chiu, W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Human fatty acid synthase: properties and molecular cloning. Jayakumar, A., Tai, M.H., Huang, W.Y., al-Feel, W., Hsu, M., Abu-Elheiga, L., Chirala, S.S., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Bandyopadhyay, S., Zhan, R., Wang, Y., Pai, S.K., Hirota, S., Hosobe, S., Takano, Y., Saito, K., Furuta, E., Iiizumi, M., Mohinta, S., Watabe, M., Chalfant, C., Watabe, K. Cancer Res. (2006)