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Gene Review

MAPK8IP3  -  mitogen-activated protein kinase 8...

Homo sapiens

Synonyms: C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JIP3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, ...
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High impact information on MAPK8IP3

  • Leukocyte common antigen-related (LAR) family receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in axon guidance [1].
  • Pin1 is enriched at the mitochondrial membrane in neurons, where it forms a physical complex with the neuron-specific JNK scaffold protein JIP3 [2].
  • The activated SEK1 dissociates from JIP3 and phosphorylates JNK2 on the Tyr-185 residue [3].
  • In the present study, we reveal that two scaffolding proteins, JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation [3].
  • Liprin-alpha/SYD-2 is a family of multidomain proteins with four known isoforms [4].

Biological context of MAPK8IP3

  • In the present study, we investigated the function of JSAP1 during PC12h cell differentiation by knocking down the level of JSAP1 [5].
  • Furthermore, we found by Western blotting that the expression levels of JSAP1 protein vary during development; there is high expression until 6 weeks after birth, which approximately corresponds to the end of the first wave of spermatogenesis [6].

Anatomical context of MAPK8IP3


Associations of MAPK8IP3 with chemical compounds

  • Taken together, these results suggest that JSAP1 is involved an integrin-mediated signaling pathway through FAK/Src by recruiting other signaling molecules, resulting in promotion of cell spreading onto FN [7].

Physical interactions of MAPK8IP3

  • JSAP1 (also termed JIP3) is a scaffold protein that interacts with specific components of the JNK signaling pathway [9].

Enzymatic interactions of MAPK8IP3

  • The complex formation was further stimulated by c-Src, in which JSAP1 was tyrosine-phosphorylated and other FAK/Src signaling molecules were recruited [7].

Other interactions of MAPK8IP3

  • We previously reported that c-Jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) functions as a putative scaffold factor in the JNK mitogen-activated protein kinase (MAPK) cascades [10].
  • Here we have defined the regions of JSAP1 responsible for the interactions with MEK1 and Raf-1 [10].
  • Taken together, these results suggest that JSAP1 regulates cell-cell interactions in PC12h cells specifically in the NGF-induced signaling pathway, and does so by modulating N-cadherin [5].


  1. LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Dunah, A.W., Hueske, E., Wyszynski, M., Hoogenraad, C.C., Jaworski, J., Pak, D.T., Simonetta, A., Liu, G., Sheng, M. Nat. Neurosci. (2005) [Pubmed]
  2. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Becker, E.B., Bonni, A. Neuron (2006) [Pubmed]
  3. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. Song, J.J., Lee, Y.J. J. Biol. Chem. (2005) [Pubmed]
  4. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. Ko, J., Na, M., Kim, S., Lee, J.R., Kim, E. J. Biol. Chem. (2003) [Pubmed]
  5. Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells. Bayarsaikhan, M., Takino, T., Gantulga, D., Sato, H., Ito, T., Yoshioka, K. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  6. Selective expression of the scaffold protein JSAP1 in spermatogonia and spermatocytes. Bayarsaikhan, M., Shiratsuchi, A., Gantulga, D., Nakanishi, Y., Yoshioka, K. Reproduction (2006) [Pubmed]
  7. A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. Takino, T., Yoshioka, K., Miyamori, H., Yamada, K.M., Sato, H. Oncogene (2002) [Pubmed]
  8. Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. Shoichet, S.A., Duprez, L., Hagens, O., Waetzig, V., Menzel, C., Herdegen, T., Schweiger, S., Dan, B., Vamos, E., Ropers, H.H., Kalscheuer, V.M. Hum. Genet. (2006) [Pubmed]
  9. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K., Ichijo, H. J. Biol. Chem. (2002) [Pubmed]
  10. A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. Kuboki, Y., Ito, M., Takamatsu, N., Yamamoto, K.I., Shiba, T., Yoshioka, K. J. Biol. Chem. (2000) [Pubmed]
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