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Gene Review

Pdgfb  -  platelet-derived growth factor beta...

Rattus norvegicus

Synonyms: PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Platelet-derived growth factor subunit B, ...
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Disease relevance of Pdgfb


Psychiatry related information on Pdgfb


High impact information on Pdgfb


Chemical compound and disease context of Pdgfb


Biological context of Pdgfb


Anatomical context of Pdgfb


Associations of Pdgfb with chemical compounds


Other interactions of Pdgfb

  • In contrast, in the heart of the SHR and WKY rat, there was an age-related decrease in expression of both PDGF receptors and of the PDGF B chain [26].
  • The amount of bFGF decreased after injury, but the amounts of VEGF and PDGF-B chain increased [27].
  • Among them, expression of PDGF-B chain mRNA preceded mesangial proliferation and expression of TGF-beta 1 preceded accumulation of mesangial matrix, indicating that these two growth factors contributed to these histological alterations [28].
  • Levels of IL-1 beta and PDGF-B chain mRNAs increased at 24 hr and remained elevated for 4 weeks [28].
  • Platelet-derived growth factor-A chain mRNA levels increased in day 3 allografts and in syngeneic LEW grafts, while PDGF-B chain mRNA levels showed no significant changes with transplantation [29].

Analytical, diagnostic and therapeutic context of Pdgfb


  1. The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity. Egawa-Tsuzuki, T., Ohno, M., Tanaka, N., Takeuchi, Y., Uramoto, H., Faigle, R., Funa, K., Ishii, Y., Sasahara, M. Exp. Neurol. (2004) [Pubmed]
  2. Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. Takahashi, T., Abe, H., Arai, H., Matsubara, T., Nagai, K., Matsuura, M., Iehara, N., Yokode, M., Nishikawa, S., Kita, T., Doi, T. J. Biol. Chem. (2005) [Pubmed]
  3. Ischemia induces the expression of the platelet-derived growth factor-B chain in neurons and brain macrophages in vivo. Iihara, K., Sasahara, M., Hashimoto, N., Uemura, Y., Kikuchi, H., Hazama, F. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  4. Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the hypoxic ventilatory response. Gozal, D., Simakajornboon, N., Czapla, M.A., Xue, Y.D., Gozal, E., Vlasic, V., Lasky, J.A., Liu, J.Y. J. Neurochem. (2000) [Pubmed]
  5. Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats. Nakagawa, H., Sasahara, M., Haneda, M., Koya, D., Hazama, F., Kikkawa, R. Diabetes Res. Clin. Pract. (2000) [Pubmed]
  6. Hippocampal interictal spikes induced by kindling: relations to behavior and EEG. Leung, L.W. Behav. Brain Res. (1988) [Pubmed]
  7. Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner. Sjölund, M., Hedin, U., Sejersen, T., Heldin, C.H., Thyberg, J. J. Cell Biol. (1988) [Pubmed]
  8. Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat. Iida, H., Seifert, R., Alpers, C.E., Gronwald, R.G., Phillips, P.E., Pritzl, P., Gordon, K., Gown, A.M., Ross, R., Bowen-Pope, D.F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Majesky, M.W., Benditt, E.P., Schwartz, S.M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  10. Angiotensin II stimulates platelet-derived growth factor-B chain expression in newborn rat vascular smooth muscle cells and neointimal cells through Ras, extracellular signal-regulated protein kinase, and c-Jun N-terminal protein kinase mechanisms. Deguchi, J., Makuuchi, M., Nakaoka, T., Collins, T., Takuwa, Y. Circ. Res. (1999) [Pubmed]
  11. Platelet-derived growth factor and growth-related genes in rat lung. II. Effect of exposure to 85% O2. Han, R.N., Buch, S., Freeman, B.A., Post, M., Tanswell, A.K. Am. J. Physiol. (1992) [Pubmed]
  12. Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. Lens, P.F., Altena, B., Nusse, R. Mol. Cell. Biol. (1986) [Pubmed]
  13. Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor. van Zoelen, E.J., van de Ven, W.J., Franssen, H.J., van Oostwaard, T.M., van der Saag, P.T., Heldin, C.H., de Laat, S.W. Mol. Cell. Biol. (1985) [Pubmed]
  14. Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc. Heeneman, S., Haendeler, J., Saito, Y., Ishida, M., Berk, B.C. J. Biol. Chem. (2000) [Pubmed]
  15. Differential regulation of platelet-derived growth factor genes in fetal rat lung fibroblasts. Buch, S., Jones, C., Liu, J., Han, R.N., Tanswell, A.K., Post, M. Exp. Cell Res. (1994) [Pubmed]
  16. Ontogeny and regulation of platelet-derived growth factor gene expression in distal fetal rat lung epithelial cells. Buch, S., Jassal, D., Cannigia, I., Edelson, J., Han, R., Liu, J., Tanswell, K., Post, M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  17. Increased expression of PDGF-B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia. Fabisiak, J.P., Evans, J.N., Kelley, J. Am. J. Respir. Cell Mol. Biol. (1989) [Pubmed]
  18. PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury. Kinnman, N., Hultcrantz, R., Barbu, V., Rey, C., Wendum, D., Poupon, R., Housset, C. Lab. Invest. (2000) [Pubmed]
  19. Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo. Lindner, V., Reidy, M.A. Am. J. Pathol. (1995) [Pubmed]
  20. Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kliem, V., Johnson, R.J., Alpers, C.E., Yoshimura, A., Couser, W.G., Koch, K.M., Floege, J. Kidney Int. (1996) [Pubmed]
  21. Platelet-derived growth factor and regulation of Schwann cell proliferation in vivo. Hardy, M., Reddy, U.R., Pleasure, D. J. Neurosci. Res. (1992) [Pubmed]
  22. Differential regulation of the genes encoding platelet-derived growth factor receptor and its ligand in rat lung during microvascular and alveolar wall remodeling in hyperoxia. Powell, P.P., Wang, C.C., Jones, R. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  23. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Hashimoto, M., Yamauchi, T., Ogura, T., Oishi, T., Mimura, Y., Otsuka, F., Kashihara, N., Makino, H. American journal of nephrology. (1999) [Pubmed]
  24. The angiotensin I-converting enzyme inhibitor, cilazapril inhibits the platelet-derived growth factor B chain expression in glomeruli of spontaneously hypertensive rats. Yamauchi, T., Ogura, T., Oishi, T., Omiya, T., Ota, Z. Renal physiology and biochemistry. (1995) [Pubmed]
  25. Platelet-derived growth factor gene expression in the kidney of malignant hypertension. Okamura, M., Konishi, Y., Nishimura, M., Negoro, N., Umetani, N., Inoue, T., Kanayama, Y., Takeda, T. Blood pressure. Supplement. (1992) [Pubmed]
  26. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Sarzani, R., Arnaldi, G., Takasaki, I., Brecher, P., Chobanian, A.V. Hypertension (1991) [Pubmed]
  27. Increase of protein tyrosine phosphorylation in rat retina after ischemia-reperfusion injury. Hayashi, A., Koroma, B.M., Imai, K., de Juan, E. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  28. Expression of mRNA's of cytokines and growth factors in experimental glomerulonephritis. Onbe, T., Kashihara, N., Yamasaki, Y., Makino, H., Ota, Z. Res. Commun. Mol. Pathol. Pharmacol. (1994) [Pubmed]
  29. Growth factor transcripts in rat renal transplants. Paul, L.C., Saito, K., Davidoff, A., Benediktsson, H. Am. J. Kidney Dis. (1996) [Pubmed]
  30. Antisense oligodeoxynucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development. Souza, P., Sedlackova, L., Kuliszewski, M., Wang, J., Liu, J., Tseu, I., Liu, M., Tanswell, A.K., Post, M. Development (1994) [Pubmed]
  31. Platelet-derived growth factor-b expression induced after rat peripheral nerve injuries. Oya, T., Zhao, Y.L., Takagawa, K., Kawaguchi, M., Shirakawa, K., Yamauchi, T., Sasahara, M. Glia (2002) [Pubmed]
  32. Electrode cuff-induced changes in DNA and PDGF gene expression in the rat carotid artery. Bilder, G.E., Kasiewski, C.J., Costello, R.J., Hodge, T.G., Perrone, M.H. Atherosclerosis (1993) [Pubmed]
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