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Chemical Compound Review

SureCN414     1-benzylimidazole

Synonyms: CHEMBL14192, CCRIS 5821, AG-F-50746, ACMC-209jp9, ANW-29803, ...
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Disease relevance of NSC 126828


High impact information on NSC 126828


Biological context of NSC 126828

  • In isolated ventricular strips of rabbits, 6.3 times 10(-5) M 1-benzylimidazole (BI) increased contractile force by 100%, and in the intact cat, 0.5 mg/kg of BI increased cardiac output by 30 to 40% [7].
  • Pretreatment with 1-benzylimidazole restored renal function, eicosanoid release, and renal blood flow to sham levels [8].
  • Pre-incubation of 2AA in the presence of N-benzylimidazole significantly increased the activation of 2AA by S9 from BNF- and PB-treated rats, which suggests that CYPs play minor role in 2AA metabolic activation by rat liver S9 fractions [9].

Anatomical context of NSC 126828


Associations of NSC 126828 with other chemical compounds


Gene context of NSC 126828


Analytical, diagnostic and therapeutic context of NSC 126828


  1. Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole. Pettigrew, L.C., Hazle, J.D., Gutierrez, G., Smith, C.D., Ogletree, M.L. Neurol. Res. (1992) [Pubmed]
  2. Effects of a selective thromboxane A2 synthetase inhibitor on immune complex glomerulonephritis. Saito, H., Ideura, T., Takeuchi, J. Nephron (1984) [Pubmed]
  3. Coordinate induction of peroxisomal beta-oxidation activity and cytosolic epoxide hydrolase activity. Oesch, F., Schladt, L. Pharmacol. Ther. (1987) [Pubmed]
  4. Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Staub, R.E., Quistad, G.B., Casida, J.E. Chem. Res. Toxicol. (1998) [Pubmed]
  5. Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis). Oguro, T., Kaneko, E., Kaneko, Y., Numazawa, S., Imaoka, S., Funae, Y., Mikami, T., Yoshida, T. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  6. Haemostatic mechanism in the endometrium: role of cyclo-oxygenase products and coagulation factors. Gelety, T.J., Chaudhuri, G. Br. J. Pharmacol. (1995) [Pubmed]
  7. Cardiovascular effects of 1-benzylimidazole. Tuttle, R.S., Garcia-Minor, C., Simon, M. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  8. Downstream effects of splanchnic ischemia-reperfusion injury on renal function and eicosanoid release. Rothenbach, P., Turnage, R.H., Iglesias, J., Riva, A., Bartula, L., Myers, S.I. J. Appl. Physiol. (1997) [Pubmed]
  9. The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied. Veres, Z., Török, G., Tóth, E., Vereczkey, L., Jemnitz, K. Mutat. Res. (2005) [Pubmed]
  10. Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate. Madan, A., Parkinson, A., Faiman, M.D. Biochem. Pharmacol. (1993) [Pubmed]
  11. Roles of FMO and CYP450 in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite. Pike, M.G., Martin, Y.N., Mays, D.C., Benson, L.M., Naylor, S., Lipsky, J.J. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  12. Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole. Navas, J.M., Chana, A., Herradón, B., Segner, H. Environ. Toxicol. Chem. (2003) [Pubmed]
  13. Metabolic activation of n-butyraldoxime by rat liver microsomal cytochrome P450. A requirement for the inhibition of aldehyde dehydrogenase. DeMaster, E.G., Redfern, B., Shirota, F.N., Crankshaw, D.L., Nagasawa, H.T. Biochem. Pharmacol. (1993) [Pubmed]
  14. Effect of hypolipidemic compounds on lauric acid hydroxylation and phase II enzymes. Thomas, H., Schladt, L., Knehr, M., Post, K., Oesch, F., Boiteux-Antoine, A.F., Fournel-Gigleux, S., Magdalou, J., Siest, G. Biochem. Pharmacol. (1989) [Pubmed]
  15. Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity. Sharer, J.E., Duescher, R.J., Elfarra, A.A. Drug Metab. Dispos. (1992) [Pubmed]
  16. Studies on the identity of the heme-binding cysteinyl residue in rabbit liver microsomal cytochrome P-450 isozyme 2. Black, S.D., Coon, M.J. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  17. Thromboxane receptor antagonism and synthase inhibition in cerebral ischemia. Pettigrew, L.C., Kryscio, R.J. Prostaglandins Leukot. Essent. Fatty Acids (1993) [Pubmed]
  18. Involvement of testosterone in the induction of hepatic microsomal cytochrome P-450 2B1/2 (P-450 2B1/2) by 1-benzylimidazole in male and female rats: sex-differentiated induction of P-450 2B1/2 species. Kobayashi, Y., Yoshida, T., Kotani, E., Aoyagi, T., Kuroiwa, Y., Tobinaga, S. Biochim. Biophys. Acta (1994) [Pubmed]
  19. Enhancement of bleomycin-mediated DNA damage by epidermal microsomal enzymes. Bickers, D.R., Dixit, R., Mukhtar, H. Biochim. Biophys. Acta (1984) [Pubmed]
  20. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. Magdalou, J., Totis, M., Boiteux-Antoine, A.F., Fournel-Gigleux, S., Siest, G., Schladt, L., Oesch, F. Biochem. Pharmacol. (1988) [Pubmed]
  21. Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. Störmer, E., Roots, I., Brockmöller, J. British journal of clinical pharmacology. (2000) [Pubmed]
  22. Mechanisms of 1,3-butadiene oxidations to butadiene monoxide and crotonaldehyde by mouse liver microsomes and chloroperoxidase. Elfarra, A.A., Duescher, R.J., Pasch, C.M. Arch. Biochem. Biophys. (1991) [Pubmed]
  23. Comparative induction of drug-metabolizing enzymes by hypolipidaemic compounds. Boiteux-Antoine, A.F., Magdalou, J., Fournel-Gigleux, S., Siest, G. Gen. Pharmacol. (1989) [Pubmed]
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