The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

RNU1-1  -  RNA, U1 small nuclear 1

Homo sapiens

Synonyms: HSD1, HU1-1, RNU1, RNU1A, RNU1A3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RNU1A3


High impact information on RNU1A3


Biological context of RNU1A3


Associations of RNU1A3 with chemical compounds

  • The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids [1].
  • Compared with unstressed controls, all types of stress significantly increased HSD1 activity (146% cannula, 130% NaCl, and 253% HCl), phosphoenolpyruvate carboxykinase activity (51% cannula, 48% NaCl, and 86% HCl), and glycemia (29% cannula, 30% NaCl, and 41% HCl), but decreased hepatic glycogen (68% cannula, 68% NaCl, and 78% HCl) [4].


  1. Glucocorticoids in adipocytes stimulate visceral obesity. Wolf, G. Nutr. Rev. (2002) [Pubmed]
  2. Enhanced 11beta-hydroxysteroid dehydrogenase activity, the metabolic syndrome, and systemic hypertension. Sukhija, R., Kakar, P., Mehta, V., Mehta, J.L. Am. J. Cardiol. (2006) [Pubmed]
  3. 11beta Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle. Jang, C., Obeyesekere, V.R., Dilley, R.J., Alford, F.P., Inder, W.J. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
  4. Effect of stress on hepatic 11beta-hydroxysteroid dehydrogenase activity and its influence on carbohydrate metabolism. Altuna, M.E., Lelli, S.M., Mart??n de Viale, L.C., Damasco, M.C. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  5. Glucocorticoid exposure and tissue gene expression of 11{beta} HSD-1, 11{beta} HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth. McNeil, C.J., Nwagwu, M.O., Finch, A.M., Page, K.R., Thain, A., McArdle, H.J., Ashworth, C.J. Reproduction (2007) [Pubmed]
WikiGenes - Universities