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Gene Review

ADRB1  -  adrenoceptor beta 1

Bos taurus

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  • 4. The adenylate cyclase of SMC was more sensitive to prostaglandins (with the ED50 for PGI2 being 0.024 mu mol/L) and glucagon than that of EC, and responded modestly to catecholamines and was almost selectively sensitive to beta1-adrenoceptor agonists [15].


  1. Reconstitution of beta 1-adrenoceptor-dependent adenylate cyclase from purified components. Feder, D., Im, M.J., Klein, H.W., Hekman, M., Holzhöfer, A., Dees, C., Levitzki, A., Helmreich, E.J., Pfeuffer, T. EMBO J. (1986) [Pubmed]
  2. Prediction of structure and function of G protein-coupled receptors. Vaidehi, N., Floriano, W.B., Trabanino, R., Hall, S.E., Freddolino, P., Choi, E.J., Zamanakos, G., Goddard, W.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion. Tang, S.S., Stevenson, L., Dzau, V.J. Circ. Res. (1990) [Pubmed]
  4. Regional difference in the response mediated by beta 1-adrenoceptor subtype in bovine cerebral arteries. Ayajiki, K., Toda, N. J. Cereb. Blood Flow Metab. (1992) [Pubmed]
  5. The affinity of betaxolol, a beta 1-adrenoceptor-selective blocking agent, for beta-adrenoceptors in the bovine trachea and heart. Satoh, E., Narimatsu, A., Hosohata, Y., Tsuchihashi, H., Nagatomo, T. Br. J. Pharmacol. (1993) [Pubmed]
  6. Factors controlling beta 1-adrenoceptor affinity and selectivity. Ijzerman, A.P., Dorlas, R., Aué, G.H., Bultsma, T., Timmerman, H. Biochem. Pharmacol. (1985) [Pubmed]
  7. Direct beta-adrenergic stimulation of aldosterone secretion in cultured bovine adrenal subcapsular cells. De Léan, A., Racz, K., McNicoll, N., Desrosiers, M.L. Endocrinology (1984) [Pubmed]
  8. Binding of alpha- and beta gamma-subunits of Go to beta 1-adrenoceptor in sealed unilamellar lipid vesicles. Kurstjens, N.P., Fröhlich, M., Dees, C., Cantrill, R.C., Hekman, M., Helmreich, E.J. Eur. J. Biochem. (1991) [Pubmed]
  9. Neuronally released (-)-noradrenaline relaxes smooth muscle of calf trachea mainly through beta 1-adrenoceptors: comparison with (-)-adrenaline and relation to adenylate cyclase stimulation. Lemonine, H., Novotny, G.E., Kaumann, A.J. Naunyn Schmiedebergs Arch. Pharmacol. (1989) [Pubmed]
  10. Molecular cloning and pharmacological characterization of the bovine beta 3-adrenergic receptor. Piétri-Rouxel, F., Lenzen, G., Kapoor, A., Drumare, M.F., Archimbault, P., Strosberg, A.D., Manning, B.S. Eur. J. Biochem. (1995) [Pubmed]
  11. Beta adrenoceptors mediate the catecholamine-induced stimulation of oxytocin secretion from cultured bovine granulosa cells. Luck, M.R., Münker, M. Reprod. Fertil. Dev. (1991) [Pubmed]
  12. Bovine pituitary folliculo-stellate cells have beta-adrenergic receptors positively coupled to adenosine 3',5'-cyclic monophosphate production. Findell, P.R., Weiner, R.I. Endocrinology (1988) [Pubmed]
  13. Interactions of pure beta gamma-subunits of G-proteins with purified beta 1-adrenoceptor. Im, M.J., Holzhöfer, A., Böttinger, H., Pfeuffer, T., Helmreich, E.J. FEBS Lett. (1988) [Pubmed]
  14. Subclassification of beta-adrenoceptors responsible for steroidogenesis in primary cultures of bovine adrenocortical zona fasciculata/reticularis cells. Lightly, E.R., Walker, S.W., Bird, I.M., Williams, B.C. Br. J. Pharmacol. (1990) [Pubmed]
  15. Comparison of effects of vasoactive agents on adenylate cyclase activity in endothelial and smooth muscle cells from the same specimen of fetal bovine aorta. Ashikaga, T., Kishi, Y., Numano, F. Clin. Exp. Pharmacol. Physiol. (1996) [Pubmed]
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