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Chemical Compound Review

Butaxamine     1-(2,5-dimethoxyphenyl)-2- (tert...

Synonyms: Butaxamin, Butaxamina, Butaxaminum, CHEMBL289093, SureCN4745452, ...
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  • Butoxamine alone depressed the granulocyte labeling index and granulocyte-monocyte colony-forming Cell (GM-CFC) suicide rate at a dose of 3 micrograms/g body weight [1].
  • Rabbits treated with dl-propranolol (4 or 8 mg/kg i.p.) or butoxamine (15 or 30 mg/kg i.p.) produced significantly less ESF in response to hypoxia than did saline-treated control animals [2].
  • Aerosol administration of the beta antagonists, propranolol (beta 1 and beta 2), atenolol (beta 1), and butoxamine (beta 2) decreased dynamic compliance (Cdyn) and increased pulmonary resistance (RL) in the principal ponies during airway obstruction, but were without effect when the ponies were in clinical remission [3].
  • Butoxamine provided some protection against the arrhythmia within a narrow dose range (53 to 79 mg/kg) [4].
  • The results showed that drugs with beta 2-adrenoceptor agonist activity and l-ephedrine caused hyperthermia in rats and this effect was selectively inhibited by pretreatment of animals with propranolol (a mixed beta-adrenoceptor antagonist) or butoxamine (a selective beta 2-adrenoceptor antagonist) [5].

Psychiatry related information on BUTOXAMINE HYDROCHLORIDE

  • Pretreatment with the beta-adrenergic antagonist, butoxamine, reduced the effects of social confrontation by approximately 50%, and adrenal demedullation almost abolished it without significantly affecting the social interaction [6].

High impact information on BUTOXAMINE HYDROCHLORIDE


Chemical compound and disease context of BUTOXAMINE HYDROCHLORIDE

  • Based on the proposed selectivity of butoxamine for beta2 adrenergic receptors and of practolol for beta1 adrenergic receptors, it is suggested that ESF production in rabbits exposed to hypoxia may involve the activation of beta2 adrenergic receptors [2].


  • The inhibition curves obtained with procaterol and butoxamine, with apparent Kd values of 3.1 X 10(-9) M and 4.9 X 10(-9) M, further evidence that the high-affinity binding sites correspond to a homogeneous beta 2-receptor subtype [10].
  • Atenolol, a beta 1-receptor antagonist, inhibited SCS-induced vasodilation only in the skin, whereas the beta 2-receptor antagonist butoxamine selectively depressed the muscle response [11].
  • Metoprolol and butoxamine had no effect on the 8-OH-DPAT-induced increase in defecation, thereby excluding an influence of beta-adrenoceptors [12].
  • Therefore, it is suggested that alpha-adrenergic stimulation is involved in the mechanism of diuresis by practolol, a beta1-blocker, and that dopaminergic stimulation is involved in the diuresis caused by butoxamine, a beta2-blocker [13].
  • In the same pigs, after hemodynamic variables had returned to the baseline values, blockade of beta2-adrenergic receptors with butoxamine caused an increase in aortic blood pressure and an increase in renal and mesenteric resistance [14].



Associations of BUTOXAMINE HYDROCHLORIDE with other chemical compounds




Analytical, diagnostic and therapeutic context of BUTOXAMINE HYDROCHLORIDE


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