Disease relevance of Osseointegration

• Because photon beams used in head and neck cancer treatment are most often directed parallel to the screw axes, these results suggest that failures of prosthetic osseointegration are unlikely to be explained by an overdosage at the bone/titanium interface [1].
• These findings clearly demonstrate that OVX-induced osteopenia impairs the osseointegration of HA-coated titanium implants and that ibandronate, administered at doses analogous to those used to clinically treat osteoporosis and MBD, counters this harmful effect [2].
• Recent studies in rat models demonstrate improved osseointegration of joint implants following ibandronate therapy, with potential application in patients with conditions such as degenerative arthritis or osteoporosis [3].
• The production of OPN as one of the earliest, and latest, secretory activities of the osteoblast lineage is discussed, together with a consideration of the role of OPN in cement lines and laminae limitantes in bone and in other normal, pathological and healing MTs such as teeth, kidney stones, bone wound healing and implant osseointegration [4].

Psychiatry related information on Osseointegration

• Effects of alcohol consumption on osseointegration of titanium implants in rabbits [5].

High impact information on Osseointegration

• Low protein intake is associated with impaired titanium implant osseointegration [6].
• The enhanced formation of focal adhesions by osteoblasts plated on surfaces coated with extracellular matrix proteins suggests that precoating titanium and other implant materials with extracellular matrix proteins may improve osseointegration [7].
• Osteoblast differentiation and extracellular matrix production are pivotal processes for implant osseointegration or bone tissue engineering [8].
• These results suggest that ROS generated from the TiO2 layer may be involved in creating appropriate conditions for the osseointegration of dental implants into alveolar bone tissues [9].
• Hydroxyapatite (HA)-coated implants were developed to promote osseointegration of titanium implants and to overcome the mechanical drawbacks of solid HA implants [10].

Biological context of Osseointegration

• These results suggest that the FN(8-10)-modified titanium surface can be used to improve the osseointegration of titanium implants by enhancing bone formation [11].
• Intramedullary osseointegration: development of a rodent model and study of histology and neuropeptide changes around titanium implants [12].
• Nevertheless, a trend was evident in these observations: while a rough implant surface may enhance the rate of osseointegration, it is not able to significantly change the bone density, and an implant placed low-density bone is at a higher risk of failure when occlusal loading begins [13].
• Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments [14].
• Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration [15].

Anatomical context of Osseointegration

• This study explores the potential for osseointegration engineering with dental pulp cells (DPCs) by testing a hypothesis that DPCs generate mineralized tissue on titanium [16].
• Response of bone marrow to titanium implants: osseointegration and the establishment of a bone marrow-titanium interface in mice [17].
• An implantable hearing device: osseointegration of a titanium-magnet temporal bone stimulator [18].
• CONCLUSIONS: Osseointegration was successful in immediate implant placement sites with horizontal defect dimensions wider than 4 mm in humans when SLA titanium implants were completely covered with connective tissue membranes [19].
• The aim of this study was to compare the degree of osseointegration around titanium screws placed into the areas between guided bone augmented sites and guided bone graft augmented sites in 8 Japanese white rabbit tibia [20].

Associations of Osseointegration with chemical compounds

• Ibandronate may, therefore, have a role in improving the osseointegration of implants in patients with osteoporosis and MBD [2].
• Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions [21].
• The mechanism(s) by which fluoride ion modification of c.p.titanium enhanced osteoblastic differentiation and osseointegration merit careful investigation [22].
• Commercially grade 2 titanium rods (diameter 2 mm, length: 3 mm), vacuum annealed and hydrofluoric acid etched was selected for its promising surface characteristics to achieve good direct osseointegration [23].
• Wollastonite coating was shown to stimulate more bone formation on its surface than titanium coating after implantation for 1 month, enhancing the short-term osseointegration properties of implant [24].

Gene context of Osseointegration

• The effect of combination of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor or insulin-like growth factor-I on dental implant osseointegration by confocal laser scanning microscopy [25].
• It can be concluded that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone [26].
• In this study, we used a rodent femur model of intramedullary osseointegration to analyze the changes in immunoreactivity of ECM-controlling matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinase-3 (TIMP-3), and tumor necrosis factor alpha (TNF-alpha) during osseointegration [27].
• Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices [28].
• Therefore, calcium phosphate implants combined with TGF-beta1 might improve osseointegration [29].

Analytical, diagnostic and therapeutic context of Osseointegration

• The aim of this study was to evaluate the ability of titanium dioxide (TiO2) to generate ROS in the presence of H2O2 and to determine whether any ROS thus generated play a role in osseointegration, as measured by electron spin resonance (ESR) spin-trapping with 5,5-dimethyl-1-pyrolline-N-oxide (DMPO) [9].
• A new method - osseointegration - involves a titanium screw being operated into the jawbone and the attachment of a fixed bridge [30].
• The aim of the present study was to investigate the histological behavior (osseointegration) of loaded zirconia implants in an animal model and to compare it with the behavior of titanium implants [31].
• Light microscopy, and transmission and scanning electron microscopy were used to evaluate osseointegration of extraoral titanium implant surfaces treated by either autoclaving, exposure to ultraviolet light (UV), or radiofrequency glow discharge (RFGD) [32].
• The aim of the present study was to explore the possibility of achieving osseointegration of dental titanium implants, inserted into alveoli immediately after tooth extraction, by covering the recipient site with a teflon membrane [33].

References