The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Osseointegration

  • Because photon beams used in head and neck cancer treatment are most often directed parallel to the screw axes, these results suggest that failures of prosthetic osseointegration are unlikely to be explained by an overdosage at the bone/titanium interface [1].
  • These findings clearly demonstrate that OVX-induced osteopenia impairs the osseointegration of HA-coated titanium implants and that ibandronate, administered at doses analogous to those used to clinically treat osteoporosis and MBD, counters this harmful effect [2].
  • Recent studies in rat models demonstrate improved osseointegration of joint implants following ibandronate therapy, with potential application in patients with conditions such as degenerative arthritis or osteoporosis [3].
  • The production of OPN as one of the earliest, and latest, secretory activities of the osteoblast lineage is discussed, together with a consideration of the role of OPN in cement lines and laminae limitantes in bone and in other normal, pathological and healing MTs such as teeth, kidney stones, bone wound healing and implant osseointegration [4].

Psychiatry related information on Osseointegration


High impact information on Osseointegration


Biological context of Osseointegration


Anatomical context of Osseointegration


Associations of Osseointegration with chemical compounds


Gene context of Osseointegration


Analytical, diagnostic and therapeutic context of Osseointegration


  1. Dose variation at bone/titanium interfaces using titanium hollow screw osseointegrating reconstruction plates. Allal, A.S., Richter, M., Russo, M., Rouzaud, M., Dulguerov, P., Kurtz, J.M. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  2. The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats. Kurth, A.H., Eberhardt, C., Müller, S., Steinacker, M., Schwarz, M., Bauss, F. Bone (2005) [Pubmed]
  3. Ibandronate in metastatic bone disease: a review of preclinical data. Bauss, F., Body, J.J. Anticancer Drugs (2005) [Pubmed]
  4. Osteopontin: an interfacial extracellular matrix protein in mineralized tissues. McKee, M.D., Nanci, A. Connect. Tissue Res. (1996) [Pubmed]
  5. Effects of alcohol consumption on osseointegration of titanium implants in rabbits. Koo, S., König, B., Mizusaki, C.I., Allegrini, S., Yoshimoto, M., Carbonari, M.J. Implant dentistry. (2004) [Pubmed]
  6. Low protein intake is associated with impaired titanium implant osseointegration. Dayer, R., Rizzoli, R., Kaelin, A., Ammann, P. J. Bone Miner. Res. (2006) [Pubmed]
  7. Formation of focal adhesions by osteoblasts adhering to different substrata. Schneider, G., Burridge, K. Exp. Cell Res. (1994) [Pubmed]
  8. Apatite/amelogenin coating on titanium promotes osteogenic gene expression. Du, C., Schneider, G.B., Zaharias, R., Abbott, C., Seabold, D., Stanford, C., Moradian-Oldak, J. J. Dent. Res. (2005) [Pubmed]
  9. Characterization by electron spin resonance spectroscopy of reactive oxygen species generated by titanium dioxide and hydrogen peroxide. Lee, M.C., Yoshino, F., Shoji, H., Takahashi, S., Todoki, K., Shimada, S., Kuse-Barouch, K. J. Dent. Res. (2005) [Pubmed]
  10. The process of physical weakening and dissolution of the HA-coated implant in bone and soft tissue. Ogiso, M., Yamashita, Y., Matsumoto, T. J. Dent. Res. (1998) [Pubmed]
  11. The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior. Ku, Y., Chung, C.P., Jang, J.H. Biomaterials (2005) [Pubmed]
  12. Intramedullary osseointegration: development of a rodent model and study of histology and neuropeptide changes around titanium implants. Ysander, M., Brånemark, R., Olmarker, K., Myers, R.R. Journal of rehabilitation research and development. (2001) [Pubmed]
  13. A histometric comparison of smooth and rough titanium implants in human low-density jawbone. Trisi, P., Rao, W., Rebaudi, A. The International journal of oral & maxillofacial implants. (1999) [Pubmed]
  14. Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments. Giavaresi, G., Branda, F., Causa, F., Luciani, G., Fini, M., Nicoli Aldini, N., Rimondini, L., Ambrosio, L., Giardino, R. The International journal of artificial organs. (2004) [Pubmed]
  15. Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Sigurdsson, T.J., Fu, E., Tatakis, D.N., Rohrer, M.D., Wikesjö, U.M. Clinical oral implants research. (1997) [Pubmed]
  16. Molecular and biomechanical characterization of mineralized tissue by dental pulp cells on titanium. Nakamura, H., Saruwatari, L., Aita, H., Takeuchi, K., Ogawa, T. J. Dent. Res. (2005) [Pubmed]
  17. Response of bone marrow to titanium implants: osseointegration and the establishment of a bone marrow-titanium interface in mice. Rahal, M.D., Brånemark, P.I., Osmond, D.G. The International journal of oral & maxillofacial implants. (1993) [Pubmed]
  18. An implantable hearing device: osseointegration of a titanium-magnet temporal bone stimulator. Dormer, K.J., Richard, G., McGee, M., Hough, J.V., Shew, R.L. The American journal of otology. (1986) [Pubmed]
  19. Immediate implants covered with connective tissue membranes: human biopsies. Wilson, T.G., Carnio, J., Schenk, R., Cochran, D. J. Periodontol. (2003) [Pubmed]
  20. Osseointegration around titanium screws placed into the areas between guided bone augmented sites compared with osseointegration around guided bone graft augmented sites in rabbit tibia. Ito, K., Nanba, K., Nishida, T., Fujikawa, K., Murai, S. Journal of oral science. (1999) [Pubmed]
  21. Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions. Ignatius, A., Peraus, M., Schorlemmer, S., Augat, P., Burger, W., Leyen, S., Claes, L. Biomaterials (2005) [Pubmed]
  22. Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit-blasted c.p. titanium endosseous implants. Cooper, L.F., Zhou, Y., Takebe, J., Guo, J., Abron, A., Holmén, A., Ellingsen, J.E. Biomaterials (2006) [Pubmed]
  23. In vitro and in vivo behaviour of Ca- and P-enriched anodized titanium. Fini, M., Cigada, A., Rondelli, G., Chiesa, R., Giardino, R., Giavaresi, G., Nicoli Aldini, N., Torricelli, P., Vicentini, B. Biomaterials (1999) [Pubmed]
  24. In vivo evaluation of plasma-sprayed wollastonite coating. Xue, W., Liu, X., Zheng, X., Ding, C. Biomaterials (2005) [Pubmed]
  25. The effect of combination of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor or insulin-like growth factor-I on dental implant osseointegration by confocal laser scanning microscopy. Lan, J., Wang, Z., Wang, Y., Wang, J., Cheng, X. J. Periodontol. (2006) [Pubmed]
  26. Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. A histometric study in miniature pigs. Terheyden, H., Jepsen, S., Möller, B., Tucker, M.M., Rueger, D.C. Clinical oral implants research. (1999) [Pubmed]
  27. Titanium implants induce expression of matrix metalloproteinases in bone during osseointegration. Shubayev, V.I., Brånemark, R., Steinauer, J., Myers, R.R. Journal of rehabilitation research and development. (2004) [Pubmed]
  28. Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMP-1, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics. Oum'hamed, Z., Garnotel, R., Josset, Y., Trenteseaux, C., Laurent-Maquin, D. Journal of biomedical materials research. Part A. (2004) [Pubmed]
  29. Transforming growth factor-beta1 incorporated during setting in calcium phosphate cement stimulates bone cell differentiation in vitro. Blom, E.J., Klein-Nulend, J., Klein, C.P., Kurashina, K., van Waas, M.A., Burger, E.H. J. Biomed. Mater. Res. (2000) [Pubmed]
  30. Psychological reactions to edentulousness and treatment with jawbone-anchored bridges. Blomberg, S., Lindquist, L.W. Acta psychiatrica Scandinavica. (1983) [Pubmed]
  31. Loaded custom-made zirconia and titanium implants show similar osseointegration: an animal experiment. Kohal, R.J., Weng, D., Bächle, M., Strub, J.R. J. Periodontol. (2004) [Pubmed]
  32. Microscopic observations of the bone/implant interface of surface-treated titanium implants. Budd, T.W., Bielat, K.L., Meenaghan, M.A., Schaaf, N.G. The International journal of oral & maxillofacial implants. (1991) [Pubmed]
  33. Guided tissue regeneration ensures osseointegration of dental implants placed into extraction sockets. An experimental study in monkeys. Warrer, L., Gotfredsen, K., Hjørting-Hansen, E., Karring, T. Clinical oral implants research. (1991) [Pubmed]
WikiGenes - Universities