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Gene Review

Igfbp4  -  insulin-like growth factor binding protein 4

Rattus norvegicus

Synonyms: IBP-4, IBP4, IGF-BP4, IGF-binding protein 4, IGFBP-4, ...
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Disease relevance of Igfbp4


High impact information on Igfbp4


Chemical compound and disease context of Igfbp4


Biological context of Igfbp4


Anatomical context of Igfbp4

  • IGFBP-2 mRNA was expressed in glomeruli, medullary ray collecting ducts, pelvic smooth muscle and uroepithelium, and the papilla tip; IGFBP-3 mRNA was localized to the cortical interstitium, whereas IGFBP-4 mRNA was expressed in proximal tubules, medullary ray collecting ducts, and glomeruli [13].
  • In the decidual vasculature at Day (d) 8.0, both IGFBP-3 and IGFBP-4 mRNAs are detected in dilating blood vessels, with BP-3 most prominent in the antimesometrial plexus and BP-4 primarily at the mesometrial pole [14].
  • Activation of protein kinase-A (PKA) in rat granulosa cells has been shown to modulate the relative expression of IGFBP-4 and -5 transcripts and proteins [15].
  • IGFBP-4 mRNA was localized only in the luminal epithelium of the endometrium [16].
  • IGFBP-3 and IGFBP-4 mRNAs were detected in both the liver and pancreas throughout the developmental period studied [17].

Associations of Igfbp4 with chemical compounds


Regulatory relationships of Igfbp4


Other interactions of Igfbp4

  • The binding affinities of the recombinant protein and IGFBP-4 secreted by rat cells to IGF-I were compared using a newly developed binding assay [9].
  • However IGFBP-4 seems to be the only IGFBP with no potential to enhance the mitogenic actions of the IGFs [9].
  • IGFBP-3 mRNA increased in amount immediately following birth, while the quantity of IGFBP-4 mRNA increased sharply in liver from postnatal day 21, but declined in the pancreas. mRNA for IGFBP-5 or -6 was undetectable in either tissue [17].
  • IGFBP-4 immunoreactivity was restricted to the apex of the olfactory epithelium [23].
  • As opposed to the actions of other growth factors, TGF-beta 1 substantially lowered the levels of IGFBP-2 and IGFBP-4 [24].

Analytical, diagnostic and therapeutic context of Igfbp4


  1. Insulin-like growth factor binding protein-4 gene expression is induced by transfection of gap junction connexin43 gene in a C6 glioma cell line. Bradshaw, S.L., Naus, C.C., Zhu, D., Kidder, G.M., Han, V.K. Growth Regul. (1993) [Pubmed]
  2. Intact IGF-binding protein-4 and -5 and their respective fragments isolated from chronic renal failure serum differentially modulate IGF-I actions in cultured growth plate chondrocytes. Kiepe, D., Andress, D.L., Mohan, S., Ständker, L., Ulinski, T., Himmele, R., Mehls, O., Tönshoff, B. J. Am. Soc. Nephrol. (2001) [Pubmed]
  3. Hypertension increases insulin-like growth factor binding protein-4 mRNA levels in rat aorta. Anwar, A., Delafontaine, P. Hypertension (1994) [Pubmed]
  4. Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Tönshoff, B., Powell, D.R., Zhao, D., Durham, S.K., Coleman, M.E., Domené, H.M., Blum, W.F., Baxter, R.C., Moore, L.C., Kaskel, F.J. Endocrinology (1997) [Pubmed]
  5. Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta. Kobayashi, T., Kaneda, A., Kamata, K. Br. J. Pharmacol. (2003) [Pubmed]
  6. Up-regulation of insulinlike growth factor I binding sites in experimental colitis in rats. Zeeh, J.M., Hoffmann, P., Sottili, M., Eysselein, V.E., McRoberts, J.A. Gastroenterology (1995) [Pubmed]
  7. Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells. Kamyar, A., Pirola, C.J., Wang, H.M., Sharifi, B., Mohan, S., Forrester, J.S., Fagin, J.A. Circ. Res. (1994) [Pubmed]
  8. Regulation of renal growth and IGFBP-4 expression by triiodothyronine during rat development. Voci, A., Demori, n.u.l.l., Bottazzi, C., Fugassa, E. Horm. Metab. Res. (2001) [Pubmed]
  9. Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4. Chelius, D., Baldwin, M.A., Lu, X., Spencer, E.M. J. Endocrinol. (2001) [Pubmed]
  10. Cellular localization of messenger RNAs for insulin-like growth factors (IGFs), their receptors and binding proteins during fetal rat lung development. Retsch-Bogart, G.Z., Moats-Staats, B.M., Howard, K., D'Ercole, A.J., Stiles, A.D. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  11. Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon. Olesen, J.L., Heinemeier, K.M., Haddad, F., Langberg, H., Flyvbjerg, A., Kjaer, M., Baldwin, K.M. J. Appl. Physiol. (2006) [Pubmed]
  12. Insulin-like growth factor binding proteins in air- and 85% oxygen-exposed adult rat lung. Han, R.N., Han, V.K., Buch, S., Freeman, B.A., Post, M., Tanswell, A.K. Am. J. Physiol. (1998) [Pubmed]
  13. Expression of the genes encoding the rat renal insulin-like growth factor-I system. Rabkin, R., Brody, M., Lu, L.H., Chan, C., Shaheen, A.M., Gillett, N. J. Am. Soc. Nephrol. (1995) [Pubmed]
  14. Insulin-like growth factor binding protein gene expression in the pregnant rat uterus and placenta. Cerro, J.A., Pintar, J.E. Dev. Biol. (1997) [Pubmed]
  15. Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5. Chamoun, D., Choi, D., Tavares, A.B., Udoff, L.C., Levitas, E., Resnick, C.E., Rosenfeld, R.G., Adashi, E.Y. Biol. Reprod. (2002) [Pubmed]
  16. Insulin-like growth factor binding proteins show distinct patterns of expression in the rat uterus. Girvigian, M.R., Nakatani, A., Ling, N., Shimasaki, S., Erickson, G.F. Biol. Reprod. (1994) [Pubmed]
  17. The ontogeny of insulin-like growth factor (IGF) and IGF-binding protein gene expression in the rat pancreas. Hogg, J., Hill, D.J., Han, V.K. J. Mol. Endocrinol. (1994) [Pubmed]
  18. Retinoic acid increases insulin-like growth factor-binding protein-4 expression in cultured rat hepatocytes. Demori, I., Balocco, S., Gerdoni, E., Fugassa, E., Voci, A. Horm. Metab. Res. (2004) [Pubmed]
  19. Expression of insulin-like growth factor system constituents in differentiating rat osteoblastic cell populations. Jia, D., Heersche, J.N. Growth Horm. IGF Res. (2002) [Pubmed]
  20. Insulin-like growth factor binding protein expression in the hypothyroid rat is age dependent. Näntö-Salonen, K., Rosenfeld, R.G. Endocrinology (1992) [Pubmed]
  21. Developmental changes in the expression patterns of IGFs, type 1 IGF receptor and IGF-binding proteins-2 and -4 in perinatal rat lung. Batchelor, D.C., Hutchins, A.M., Klempt, M., Skinner, S.J. J. Mol. Endocrinol. (1995) [Pubmed]
  22. Transforming growth factor-alpha stimulates insulin-like growth factor binding protein-4 (IGFBP-4) expression and blocks follicle-stimulating hormone regulation of IGFBP-4 production in rat granulosa cells. Piferrer, F., Li, D., Shimasaki, S., Erickson, G.F. Mol. Cell. Endocrinol. (1997) [Pubmed]
  23. Expression of insulin-like growth factor family in the rat olfactory epithelium. Suzuki, Y., Takeda, M. Anat. Embryol. (2002) [Pubmed]
  24. Growth factor modulation of insulin-like growth factor-binding proteins in rat osteoblast-like cells. Chen, T.L., Chang, L.Y., DiGregorio, D.A., Perlman, A.J., Huang, Y.F. Endocrinology (1993) [Pubmed]
  25. Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions. Manni, A., Badger, B., Wei, L., Zaenglein, A., Grove, R., Khin, S., Heitjan, D., Shimasaki, S., Ling, N. Cancer Res. (1994) [Pubmed]
  26. Differential effect of nephrectomy on renal expressions of IGF-I and IGFBPs mRNA in selective growth hormone-deficient rats. Kobayashi, S., Ishida, A., Moriya, H., Nogami, H. Nephron (1998) [Pubmed]
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