The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Igfbp4  -  insulin-like growth factor binding protein 4

Mus musculus

Synonyms: AI875747, Band 3A, Deb2, IBP-4, IGF-binding protein 4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Igfbp4


High impact information on Igfbp4


Biological context of Igfbp4


Anatomical context of Igfbp4


Associations of Igfbp4 with chemical compounds


Regulatory relationships of Igfbp4


Other interactions of Igfbp4


Analytical, diagnostic and therapeutic context of Igfbp4


  1. Regulation of IGF-I, IGFBP-4 and IGFBP-5 gene expression by loading in mouse skeletal muscle. Awede, B., Thissen, J., Gailly, P., Lebacq, J. FEBS Lett. (1999) [Pubmed]
  2. Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Conover, C.A., Bale, L.K., Overgaard, M.T., Johnstone, E.W., Laursen, U.H., Füchtbauer, E.M., Oxvig, C., van Deursen, J. Development (2004) [Pubmed]
  3. Genome-wide search for loci controlling serum IGF binding protein levels of mice. Brockmann, G.A., Haley, C.S., Wolf, E., Karle, S., Kratzsch, J., Renne, U., Schwerin, M., Hoeflich, A. FASEB J. (2001) [Pubmed]
  4. Synthesis of the blood circulating C-terminal fragment of insulin-like growth factor (IGF)-binding protein-4 in its native conformation. Crystallization, heparin and IGF binding, and osteogenic activity. Fernández-Tornero, C., Lozano, R.M., Rivas, G., Jiménez, M.A., Ständker, L., Díaz-Gonzalez, D., Forssmann, W.G., Cuevas, P., Romero, A., Giménez-Gallego, G. J. Biol. Chem. (2005) [Pubmed]
  5. Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. Zhang, M., Smith, E.P., Kuroda, H., Banach, W., Chernausek, S.D., Fagin, J.A. J. Biol. Chem. (2002) [Pubmed]
  6. Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Wang, J., Niu, W., Witte, D.P., Chernausek, S.D., Nikiforov, Y.E., Clemens, T.L., Sharifi, B., Strauch, A.R., Fagin, J.A. Endocrinology (1998) [Pubmed]
  7. Effect of tumor necrosis factor-alpha on the expression of insulin-like growth factor I and insulin-like growth factor binding protein 4 in mouse osteoblasts. Scharla, S.H., Strong, D.D., Mohan, S., Chevalley, T., Linkhart, T.A. Eur. J. Endocrinol. (1994) [Pubmed]
  8. Expression of insulin-like growth factor binding protein-4, insulin-like growth factor-I receptor, and insulin-like growth factor-I in the mouse uterus throughout the estrous cycle. Henemyre, C., Markoff, E. Mol. Reprod. Dev. (1999) [Pubmed]
  9. Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes. Bayol, S., Brownson, C., Loughna, P.T. Cell Biochem. Funct. (2005) [Pubmed]
  10. Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis. Boney, C.M., Moats-Staats, B.M., Stiles, A.D., D'Ercole, A.J. Endocrinology (1994) [Pubmed]
  11. A quantitative RT-PCR study of the mRNA expression profile of the IGF axis during mammary gland development. Boutinaud, M., Shand, J.H., Park, M.A., Phillips, K., Beattie, J., Flint, D.J., Allan, G.J. J. Mol. Endocrinol. (2004) [Pubmed]
  12. 1,25-Dihydroxyvitamin D3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Scharla, S.H., Strong, D.D., Mohan, S., Baylink, D.J., Linkhart, T.A. Endocrinology (1991) [Pubmed]
  13. Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in mouse osteoblastic cells. Glantschnig, H., Varga, F., Klaushofer, K. Endocrinology (1996) [Pubmed]
  14. Role for cyclic adenosine monophosphate in modulating insulin-like growth factor binding protein secretion by muscle cells. McCusker, R.H., Clemmons, D.R. J. Cell. Physiol. (1998) [Pubmed]
  15. Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation. Govoni, K.E., Lee, S.K., Chadwick, R.B., Yu, H., Kasukawa, Y., Baylink, D.J., Mohan, S. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  16. Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Miyakoshi, N., Richman, C., Qin, X., Baylink, D.J., Mohan, S. Endocrinology (1999) [Pubmed]
  17. Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Ning, Y., Schuller, A.G., Bradshaw, S., Rotwein, P., Ludwig, T., Frystyk, J., Pintar, J.E. Mol. Endocrinol. (2006) [Pubmed]
  18. Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland. Allar, M.A., Wood, T.L. Endocrinology (2004) [Pubmed]
  19. Expression of IGFBPs in the developing mouse submandibular and von Ebner's glands. Suzuki, Y. Anat. Embryol. (2006) [Pubmed]
  20. Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice. Ye, P., Price, W., Kassiotis, G., Kollias, G., D'Ercole, A.J. J. Neurosci. Res. (2003) [Pubmed]
  21. Characterization of the insulin-like growth factors (IGF) axis in a cultured mouse Leydig cell line (TM-3). Hasegawa, T., Cohen, P., Hasegawa, Y., Fielder, P.J., Rosenfeld, R.G. Growth Regul. (1995) [Pubmed]
WikiGenes - Universities