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Gene Review

SLC11A1  -  solute carrier family 11 (proton-coupled...

Bos taurus

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Disease relevance of SLC11A1


High impact information on SLC11A1


Biological context of SLC11A1

  • Nramp1 gene in mouse plays a critical role in innate immunity favoring bacterial killing by macrophages in addition to its influence on adaptative immunity [1].
  • The association of NRAMP 1 gene polymorphisms with disease in cattle has been limited to a single microsatellite located within the 3'-non coding region of the bovine NRAMP 1 gene [8].
  • Comparison of the bovine, murine and human NRAMP 1 gene structures revealed a high degree of conservation in intron placement, though the lengths of several introns were less-well conserved [8].
  • All the breeds of cattle and buffaloes tested in this study coded for Gly at the position in exon VI which corresponds to the same amino acid of the murine Nramp1-resistant phenotype at position 169 [2].
  • In order to facilitate further studies on this important gene, we now report the nearly complete structure of the bovine NRAMP 1 gene, including sizes and positions of 13 introns relative to the bovine NRAMP 1 gene coding sequence and the DNA sequence of intron-exon junctions [8].

Anatomical context of SLC11A1


Other interactions of SLC11A1

  • Two new markers, NRAMP1 and ACTA1, were added to the linkage maps on BTA2 and BTA28, respectively [10].

Analytical, diagnostic and therapeutic context of SLC11A1


  1. Frequency of bovine Nramp1 (Slc11a1) alleles in Holstein and Zebu breeds. Paixão, T.A., Ferreira, C., Borges, A.M., Oliveira, D.A., Lage, A.P., Santos, R.L. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  2. Sequence analysis of the NRAMP1 genes from different bovine and buffalo breeds. Ables, G.P., Nishibori, M., Kanemaki, M., Watanabe, T. J. Vet. Med. Sci. (2002) [Pubmed]
  3. High-level expression of NRAMP1 in peripheral blood cells and tuberculous granulomas from Mycobacterium bovis-infected bovines. Estrada-Chávez, C., Pereira-Suárez, A.L., Meraz, M.A., Arriaga, C., García-Carrancá, A., Sánchez-Rodriguez, C., Mancilla, R. Infect. Immun. (2001) [Pubmed]
  4. Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival. Barthel, R., Feng, J., Piedrahita, J.A., McMurray, D.N., Templeton, J.W., Adams, L.G. Infect. Immun. (2001) [Pubmed]
  5. Coexpression of NRAMP1, iNOS, and Nitrotyrosine in Bovine Tuberculosis. Pereira-Suárez, A.L., Estrada-Chávez, C., Arriaga-Díaz, C., Espinosa-Cueto, P., Mancilla, R. Vet. Pathol. (2006) [Pubmed]
  6. Bovine natural resistance associated macrophage protein 1 (Nramp1) gene. Feng, J., Li, Y., Hashad, M., Schurr, E., Gros, P., Adams, L.G., Templeton, J.W. Genome Res. (1996) [Pubmed]
  7. Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). Capparelli, R., Alfano, F., Amoroso, M.G., Borriello, G., Fenizia, D., Bianco, A., Roperto, S., Roperto, F., Iannelli, D. Infect. Immun. (2007) [Pubmed]
  8. Structure of the bovine natural resistance associated macrophage protein (NRAMP 1) gene and identification of a novel polymorphism. Coussens, P.M., Coussens, M.J., Tooker, B.C., Nobis, W. DNA Seq. (2004) [Pubmed]
  9. Human natural resistance-associated macrophage protein is a new type of microtubule-associated protein. Tokuraku, K., Nakagawa, H., Kishi, F., Kotani, S. FEBS Lett. (1998) [Pubmed]
  10. Development and initial characterization of a Bos taurus x B. gaurus interspecific hybrid backcross panel. Riggs, P.K., Owens, K.E., Rexroad, C.E., Amaral, M.E., Womack, J.E. J. Hered. (1997) [Pubmed]
  11. Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis). Borriello, G., Capparelli, R., Bianco, M., Fenizia, D., Alfano, F., Capuano, F., Ercolini, D., Parisi, A., Roperto, S., Iannelli, D. Infect. Immun. (2006) [Pubmed]
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