Disease relevance of CCR10

• Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10 [1].
• Because of the skin-associated expression pattern of CCL27, we focused on the expression of CCL27 and CCR10 in normal skin compared with inflammatory and autoimmune skin diseases [2].
• CCR10 is expressed in cutaneous T-cell lymphoma [3].
• Here, we demonstrate extensive expression of CCR10 in skin biopsies of patients with Sezary syndrome (SS, n = 3), mycosis fungoides (MF, n = 2) and unspecified CTCL (n = 3) [3].
• Our data support a potential role of CXCR3 in CTCL and strongly suggest that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in this group of lymphoproliferative disorders [3].

High impact information on CCR10

• Circulating skin-homing CLA+ T cells, dermal microvascular endothelial cells and fibroblasts expressed CCR10 on their cell surface [1].
• CCR10 is not expressed by keratinocytes and is instead expressed by melanocytes, dermal fibroblasts, and dermal microvascular endothelial cells [2].
• CCR10 was also detected in T cells as well as in skin-derived Langerhans cells [2].
• A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues [4].
• Our results place the gene for a G-protein coupled receptor (GPR2) previously mapped to 17q within a 400 kb region on 17q21 [5].

Biological context of CCR10

• Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1 [6].
• Taken together, these data support a role for CCL28 in contributing to allergen driven airway pathologies, show that proinflammatory cytokines can induce this signal and suggest a role for CCR10 expressing cells in airway inflammation [7].
• The chromosomal location of CCR10 was determined to coincide with the CC chemokine receptor cluster on chromosome 3 (3p21.31-3p21.32) [8].
• These results indicate that CCR10 is a novel CC chemokine receptor with a unique expression pattern that would be consistent with a role in placental immunity or hematopoiesis [8].
• GPR2 responds in a mostly tonic fashion to increases in muscle tension caused by passive stretch or motor neuron-evoked contraction, whereas GPR1 responds more phasically and adapts more rapidly [9].

Anatomical context of CCR10

• Moreover, cases with positive sentinel lymph node tended to have a higher CCR10 expression compared to cases with negative sentinel lymph node (P=0.0281) [10].
• To address this issue and to understand how neuromodulation is used effectively in a motor control network, I am studying the GPR2 stretch receptor in the crustacean stomatogastric nervous system [11].

Associations of CCR10 with chemical compounds

• SDRNFLRFamide and dopamine had excitatory effects on GPR2 [12].
• Serotonin, GABA, and the peptide allatostatin-3 (AST) decreased GPR2 firing during stretch [12].

Other interactions of CCR10

• In vitro and in vivo studies on CCR10 regulation by Annexin A1 [6].
• 6. Gene GPR2 encoded a protein that most closely resembled an interleukin-8 receptor (51% in the transmembrane regions), and this gene, not expressed in the six brain regions examined, was localized to chromosome 17q21.1-q21 [13].

Analytical, diagnostic and therapeutic context of CCR10

• Aim of this study was to investigate using immunohistochemistry techniques the interrelation between T immunoreactive cells and the expression of CCR10 and its ligand CCL27 in 59 cutaneous melanocytic lesions [10].

References