Disease relevance of IGKV2-40

• Selective survival in pentazocine and tripelennamine of Pseudomonas aeruginosa serotype O11 from drug addicts [1].
• Incidence of serotype O11 in drug addicts with endocarditis is significantly higher than the incidence in patients with nonendocarditis infections (chi 2 = 32.89; P less than .001) [2].
• We found that the classical complement pathway is involved in serum killing of susceptible Aeromonas sp. mutant strains of serogroup O11, while the alternative complement pathway seems not to be involved, and that the complement activation seems to be independent of antibody [3].
• Serotypes that belong to diarrheagenic E. coli serogroups O18, O88, O8, O11, O20, O173 were identified [4].
• Nontypable strains predominated in chronic otitis media (18.9%), while serogroups O1 (18.3%), O6 (17.5%), and O11 (17.5%) were recovered most frequently among the typable isolates [5].

High impact information on IGKV2-40

• The distance between O11 of PGA and Oepsilon2 of Glu(167) is 2.61 and 2.55 A for the major and minor conformations, respectively [6].
• We report here that 20 CF isolates of P. aeruginosa, 13 of which are LPS-rough, were each capable of expressing serogroup O11 antigen when provided with the rfb locus from P. aeruginosa serogroup O11 strain PA103 on the recombinant plasmid pLPS2 [7].
• Outbreak of endocarditis caused by Pseudomonas aeruginosa serotype O11 among pentazocine and tripelennamine abusers in Chicago [2].
• With the exception of one multidrug-resistant (MDR) strain, belonging to a ubiquitous and clinically relevant serotype O11 clone, antibiotic resistance levels were relatively low [8].
• One strain belonged to serotype O157:H7, and the others belonged to serogroups O2, O8, O11, O26, O76, O103, O113, O121, O141, O166, and O174 [9].

Chemical compound and disease context of IGKV2-40

• The growth of Pseudomonas aeruginosa, particularly serotype O11, in pentazocine and tripelennamine ("T's and Blues") was evaluated as a possible explanation for the association of deep-seated infection with this organism and abuse of these drugs [1].
• Epitopes for human monoclonal antibodies and serotyping antisera against the O-specific polysaccharide of Pseudomonas aeruginosa O11 [10].

Biological context of IGKV2-40

• The missing O11 hydroxyl group in ring B creates an empty space in the intercalation cavity between the two GC base pairs, which appears to affect the stacking interactions between the aglycone and the DNA base pairs [11].
• Further comparison revealed an evolutionary relationship between O6 and O11 O-antigen gene clusters [12].
• From July 1995 to November 1996, multi-resistant Pseudomonas aeruginosa O11 was isolated from 36 patients admitted to a neurosurgery intensive care unit [13].

Associations of IGKV2-40 with chemical compounds

• The majority of isolates resistant to aminoglycosides were characterized by simultaneous resistance to gentamicin and tobramycin and belonged to serotype O11 [14].
• Structure II ([AlLH2(OH)(H2O)]2+) has the metal coordinated to the O11 and O12 groups and the O3 group protonated and is the global minimum on the potential energy surface for the interaction [15].
• A compositional sugar analysis of their LPS revealed that out of the six O-untypeable (OUT) strains, U-6443, W-90144 and AD-7999 strains belonged to chemotype II (chemotype of O2), 90A-6611 and KX-V212 strains to chemotype III (chemotype of O3, O5, O11 and O13) and X-3972 strain to chemotype IV (chemotype of O4) [16].
• We conclude that an ability of some P. aeruginosa serotype O11 strains, but not S. aureus, to survive in pentazocine and tripelennamine may explain in part a shift from S. aureus to P. aeruginosa as common pathogens of drug addicts in areas where abuse of this combination of drugs has increased [1].
• In (1), the triisopropylsiloxy group is equatorial and close intramolecular contacts between H2A and H4B [2.29 (3) A], O11 and C4 [2.934 (3) A] and O9 and C7 [2.979 (3) A] are observed.(ABSTRACT TRUNCATED AT 250 WORDS)[17]

Other interactions of IGKV2-40

• Of the 18 strains of V. cholerae isolated during this period, 15 belonged to the non-O1, non-O139 serogroups (4 belonged to O144, 3 belonged to O11, 1 each belonged to O6, O8, O12, O19, O39, and O58, and 2 strains could not be typed), 2 belonged to the O139 serogroup, and 1 belonged to the O1 serogroup [18].

Analytical, diagnostic and therapeutic context of IGKV2-40

• O11 isolates were more common in intensive care units and more resistant to all antibiotics than other isolates [19].
• The three isolates, all of serotype O11, appeared to be clonally related according to the results of genotyping by macrorestriction analysis of genomic DNA by pulsed-field gel electrophoresis and random amplification of polymorphic DNA [20].
• Furthermore, epitopes for serotyping antisera of O11 seemed to be similar to those for the human mAbs [10].
• Our results indicate that the ERIC-based PCR technique represents a rapid and simple means for typing P. aeruginosa serotype O11 with a level of discrimination equivalent to that of PFGE [21].
• DNA fingerprinting of Pseudomonas aeruginosa serotype O11 by enterobacterial repetitive intergenic consensus-polymerase chain reaction and pulsed-field gel electrophoresis [21].

References