The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TRPM5  -  transient receptor potential cation...

Homo sapiens

Synonyms: LTRPC5, LTrpC-5, LTrpC5, Long transient receptor potential channel 5, MLSN1-and TRP-related gene 1 protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TRPM5


High impact information on TRPM5


Biological context of TRPM5

  • We have recently described the occurrence of calcium signaling mechanisms in taste receptor cells via apparent store-operated channels and identified Trpm5, a novel candidate taste transduction element belonging to the mammalian family of transient receptor potential channels [3].

Anatomical context of TRPM5

  • Together with TRPM5, these channels are up till now the only molecular candidates for a class of non-selective, Ca(2+)-impermeable cation channels which are activated by elevated Ca2+ levels in the cytosol [4].
  • TRPM5, a cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes [5].
  • Mean MTR of both MS lesions and whole brain tissue was lower in patients with frontal lobe impairment (p=0.04) [6].
  • Biophysical studies of Trpm5 heterologously expressed in Xenopus oocytes and mammalian CHO-K1 cells indicate that it functions as a store-operated channel that mediates capacitative calcium entry [3].

Associations of TRPM5 with chemical compounds

  • Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close homologue, TRPM5, are the only two members of the large transient receptor potential superfamily of cation channels that are impermeable to Ca(2+) [7].
  • These results strongly suggest the possibility that arachidonic acid acts as a modulator of TRPM5 in taste signaling pathways [8].
  • The ligand specificity of the MT receptor in a normal prostate with minor amounts of progestin receptors was typical of an androgen receptor, and the ligand specificity of the R5020 receptor in a BPH specimen was typical of a progestin receptor [9].
  • Mutant MT-receptor complexes dissociate normally even at 42 degrees C; yet, in cells post-incubated at 42 degrees C with cycloheximide and a saturating concentration of ligand, their pool size decays in the rank order, MT greater than MB greater than normal [10].

Other interactions of TRPM5

  • TRPM5, which is distantly related to TRPM8, is a Ca2+-activated cation channel expressed in taste cells that is essential for sweet, bitter, and umami tastes [11].
  • TRPM5, which is the most homologous channel to TRPM4, was not modulated by DV [12].
  • In taste cells, Trpm5 is co-expressed with taste-signaling molecules such as alpha-gustducin, Ggamma(13), phospholipase C beta(2) and inositol 1,4,5-trisphosphate receptor type III [3].


  1. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Prawitt, D., Enklaar, T., Klemm, G., Gärtner, B., Spangenberg, C., Winterpacht, A., Higgins, M., Pelletier, J., Zabel, B. Hum. Mol. Genet. (2000) [Pubmed]
  2. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Prawitt, D., Monteilh-Zoller, M.K., Brixel, L., Spangenberg, C., Zabel, B., Fleig, A., Penner, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Pérez, C.A., Margolskee, R.F., Kinnamon, S.C., Ogura, T. Cell Calcium (2003) [Pubmed]
  4. Insights into TRPM4 function, regulation and physiological role. Vennekens, R., Nilius, B. Handbook of experimental pharmacology (2007) [Pubmed]
  5. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R.F., Nilius, B. Nature (2005) [Pubmed]
  6. Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis. Rovaris, M., Filippi, M., Falautano, M., Minicucci, L., Rocca, M.A., Martinelli, V., Comi, G. Neurology (1998) [Pubmed]
  7. The selectivity filter of the cation channel TRPM4. Nilius, B., Prenen, J., Janssens, A., Owsianik, G., Wang, C., Zhu, M.X., Voets, T. J. Biol. Chem. (2005) [Pubmed]
  8. Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Oike, H., Wakamori, M., Mori, Y., Nakanishi, H., Taguchi, R., Misaka, T., Matsumoto, I., Abe, K. Biochim. Biophys. Acta (2006) [Pubmed]
  9. Steroid receptor content in cytosol from normal and hyperplastic human prostates. Ekman, P., Snochowski, M., Dahlberg, E., Bression, D., Högberg, B., Gustafsson, J.A. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  10. Ligand-specific thermal misbehavior of synthetic androgen-receptor complexes in genital skin fibroblasts of subjects with familial ligand-sensitive androgen resistance. Kaufman, M., Pinsky, L., Killinger, D.W. J. Steroid Biochem. (1986) [Pubmed]
  11. Thermal gating of TRP ion channels: food for thought? Liman, E.R. Sci. STKE (2006) [Pubmed]
  12. Decavanadate modulates gating of TRPM4 cation channels. Nilius, B., Prenen, J., Janssens, A., Voets, T., Droogmans, G. J. Physiol. (Lond.) (2004) [Pubmed]
WikiGenes - Universities