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Gene Review

Pcsk1n  -  proprotein convertase subtilisin/kexin...

Mus musculus

Synonyms: AI848336, IA-4, KEP, PEN, PEN19, ...
 
 
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Disease relevance of Pcsk1n

 

High impact information on Pcsk1n

 

Biological context of Pcsk1n

 

Anatomical context of Pcsk1n

 

Associations of Pcsk1n with chemical compounds

  • Although the transgenic mice were born in the expected frequency, 21 of 22 proSAAS transgenic Cpe (fat/fat) mice died between 11 and 26 weeks of age, presumably due to greatly elevated blood glucose [1].
 

Other interactions of Pcsk1n

  • The distribution patterns of both SAAS and PC1 are broad from E9 to E11, with some enrichment in neural tube-derived tissues [8].
  • Finally, we also studied proSAAS processing in the brains of wild-type and PC2 null mice and found that proSAAS is efficiently processed in vivo [6].
  • In order to investigate the cleavage of proSAAS by prohormone convertases, we incubated recombinant His-tagged proSAAS with recombinant mouse proPC2 or furin, separated the cleavage products using high-pressure gel permeation chromatography and analyzed the products by RIA [6].
  • To explore the function of proSAAS and its derived peptides, transgenic mice were created which express proSAAS using the beta-actin promoter [1].
  • Peptides found to increase corresponded to fragments of proenkephalin, prothyrotropin-releasing hormone, provasopressin, proSAAS, secretogranin II, chromogranin B, and peptidyl-glycine-alpha-amidating mono-oxygenase in the hypothalamus [9].
 

Analytical, diagnostic and therapeutic context of Pcsk1n

References

  1. Obesity and diabetes in transgenic mice expressing proSAAS. Wei, S., Feng, Y., Che, F.Y., Pan, H., Mzhavia, N., Devi, L.A., McKinzie, A.A., Levin, N., Richards, W.G., Fricker, L.D. J. Endocrinol. (2004) [Pubmed]
  2. ProSAAS processing in mouse brain and pituitary. Mzhavia, N., Berman, Y., Che, F.Y., Fricker, L.D., Devi, L.A. J. Biol. Chem. (2001) [Pubmed]
  3. The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. Qian, Y., Devi, L.A., Mzhavia, N., Munzer, S., Seidah, N.G., Fricker, L.D. J. Biol. Chem. (2000) [Pubmed]
  4. Embryonic gene expression and pro-protein processing of proSAAS during rodent development. Morgan, D.J., Mzhavia, N., Peng, B., Pan, H., Devi, L.A., Pintar, J.E. J. Neurochem. (2005) [Pubmed]
  5. Processing of proSAAS in neuroendocrine cell lines. Mzhavia, N., Qian, Y., Feng, Y., Che, F.Y., Devi, L.A., Fricker, L.D. Biochem. J. (2002) [Pubmed]
  6. Tissue distribution and processing of proSAAS by proprotein convertases. Sayah, M., Fortenberry, Y., Cameron, A., Lindberg, I. J. Neurochem. (2001) [Pubmed]
  7. Distribution of proSAAS-derived peptides in rat neuroendocrine tissues. Feng, Y., Reznik, S.E., Fricker, L.D. Neuroscience (2001) [Pubmed]
  8. ProSAAS and prohormone convertase 1 are broadly expressed during mouse development. Feng, Y., Reznik, S.E., Fricker, L.D. Brain Res. Gene Expr. Patterns (2002) [Pubmed]
  9. Quantitative peptidomics in mice: effect of cocaine treatment. Che, F.Y., Vathy, I., Fricker, L.D. J. Mol. Neurosci. (2006) [Pubmed]
 
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