Gene Review:
Pcsk1 - proprotein convertase subtilisin/kexin type 1
Mus musculus
Synonyms:
Att-1, Furin homolog, NEC 1, Nec-1, Nec1, ...
- Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Jackson, R.S., Creemers, J.W., Ohagi, S., Raffin-Sanson, M.L., Sanders, L., Montague, C.T., Hutton, J.C., O'Rahilly, S. Nat. Genet. (1997)
- Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, R., Holst, J.J., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses. Paquet, L., Massie, B., Mains, R.E. J. Neurosci. (1996)
- Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. Berman, Y., Mzhavia, N., Polonskaia, A., Devi, L.A. J. Biol. Chem. (2001)
- Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. Jackson, R.S., Creemers, J.W., Farooqi, I.S., Raffin-Sanson, M.L., Varro, A., Dockray, G.J., Holst, J.J., Brubaker, P.L., Corvol, P., Polonsky, K.S., Ostrega, D., Becker, K.L., Bertagna, X., Hutton, J.C., White, A., Dattani, M.T., Hussain, K., Middleton, S.J., Nicole, T.M., Milla, P.J., Lindley, K.J., O'Rahilly, S. J. Clin. Invest. (2003)
- The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. Winsky-Sommerer, R., Grouselle, D., Rougeot, C., Laurent, V., David, J.P., Delacourte, A., Dournaud, P., Seidah, N.G., Lindberg, I., Trottier, S., Epelbaum, J. Neuroscience (2003)
- Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E., Lu, W., Brown, E.M., Quinn, S.J., Ingber, D.E., Zhou, J. Nat. Genet. (2003)
- SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. Constam, D.B., Robertson, E.J. Genes Dev. (2000)
- Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Li, X., Luo, Y., Starremans, P.G., McNamara, C.A., Pei, Y., Zhou, J. Nat. Cell Biol. (2005)
- HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. Ikezoe, T., Hisatake, Y., Takeuchi, T., Ohtsuki, Y., Yang, Y., Said, J.W., Taguchi, H., Koeffler, H.P. Cancer Res. (2004)
- The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells. Pajonk, F., Himmelsbach, J., Riess, K., Sommer, A., McBride, W.H. Cancer Res. (2002)
- Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells. Johnson, K., Moffa, A., Chen, Y., Pritzker, K., Goding, J., Terkeltaub, R. J. Bone Miner. Res. (1999)
- In vivo and in vitro effect of baicalein on human prostate cancer cells. Miocinovic, R., McCabe, N.P., Keck, R.W., Jankun, J., Hampton, J.A., Selman, S.H. Int. J. Oncol. (2005)
- Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3. Dey, A., Xhu, X., Carroll, R., Turck, C.W., Stein, J., Steiner, D.F. J. Biol. Chem. (2003)
- Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region). Seidah, N.G., Mattei, M.G., Gaspar, L., Benjannet, S., Mbikay, M., Chrétien, M. Genomics (1991)
- Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Zhu, X., Orci, L., Carroll, R., Norrbom, C., Ravazzola, M., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Marcinkiewicz, M., Day, R., Seidah, N.G., Chrétien, M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. Rouillé, Y., Martin, S., Steiner, D.F. J. Biol. Chem. (1995)
- The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site. Wang, J., Xu, J., Finnerty, J., Furuta, M., Steiner, D.F., Verchere, C.B. Diabetes (2001)
- Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Marzban, L., Trigo-Gonzalez, G., Zhu, X., Rhodes, C.J., Halban, P.A., Steiner, D.F., Verchere, C.B. Diabetes (2004)
- The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. Qian, Y., Devi, L.A., Mzhavia, N., Munzer, S., Seidah, N.G., Fricker, L.D. J. Biol. Chem. (2000)
- Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity. Day, R., Lazure, C., Basak, A., Boudreault, A., Limperis, P., Dong, W., Lindberg, I. J. Biol. Chem. (1998)
- The neuroendocrine chaperone 7B2 can enhance in vitro POMC cleavage by prohormone convertase PC2. Braks, J.A., Martens, G.J. FEBS Lett. (1995)
- In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3). Friedman, T.C., Loh, Y.P., Birch, N.P. Endocrinology (1994)
- Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Dey, A., Norrbom, C., Zhu, X., Stein, J., Zhang, C., Ueda, K., Steiner, D.F. Endocrinology (2004)
- Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Smeekens, S.P., Montag, A.G., Thomas, G., Albiges-Rizo, C., Carroll, R., Benig, M., Phillips, L.A., Martin, S., Ohagi, S., Gardner, P. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Distribution of proSAAS-derived peptides in rat neuroendocrine tissues. Feng, Y., Reznik, S.E., Fricker, L.D. Neuroscience (2001)
- Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. Eskeland, N.L., Zhou, A., Dinh, T.Q., Wu, H., Parmer, R.J., Mains, R.E., O'Connor, D.T. J. Clin. Invest. (1996)
- Subtilisin proprotein convertase-6 expression in the mouse uterus during implantation and artificially induced decidualization. Wong, B.S., Liu, S., Schultz, G.A., Rancourt, D.E. Mol. Reprod. Dev. (2002)
- Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. Hosaka, M., Nagahama, M., Kim, W.S., Watanabe, T., Hatsuzawa, K., Ikemizu, J., Murakami, K., Nakayama, K. J. Biol. Chem. (1991)
- The Arg617-Arg618 cleavage site in the C-terminal domain of PC1 plays a major role in the processing and targeting of the enzyme within the regulated secretory pathway. Bernard, N., Kitabgi, P., Rovere-Jovene, C. J. Neurochem. (2003)
- Obesity and diabetes in transgenic mice expressing proSAAS. Wei, S., Feng, Y., Che, F.Y., Pan, H., Mzhavia, N., Devi, L.A., McKinzie, A.A., Levin, N., Richards, W.G., Fricker, L.D. J. Endocrinol. (2004)
- Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. Ugleholdt, R., Poulsen, M.L., Holst, P.J., Irminger, J.C., Orskov, C., Pedersen, J., Rosenkilde, M.M., Zhu, X., Steiner, D.F., Holst, J.J. J. Biol. Chem. (2006)
- Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3. Fox, D.L., Good, D.J. Mol. Endocrinol. (2008)
- Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro. Rothenberg, M.E., Eilertson, C.D., Klein, K., Zhou, Y., Lindberg, I., McDonald, J.K., Mackin, R.B., Noe, B.D. J. Biol. Chem. (1995)
- Neuropeptide processing profile in mice lacking prohormone convertase-1. Pan, H., Nanno, D., Che, F.Y., Zhu, X., Salton, S.R., Steiner, D.F., Fricker, L.D., Devi, L.A. Biochemistry (2005)
- ProSAAS and prohormone convertase 1 are broadly expressed during mouse development. Feng, Y., Reznik, S.E., Fricker, L.D. Brain Res. Gene Expr. Patterns (2002)