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Gene Review

Kalrn  -  kalirin, RhoGEF kinase

Rattus norvegicus

Synonyms: Duo, Hapip, Huntingtin-associated protein-interacting protein, Kalirin, P-CIP10, ...
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Psychiatry related information on Kalrn


High impact information on Kalrn

  • The effects of Kalirin on TrkA provide a molecular basis for the requirement of Kalirin in process extension from PC12 cells and for previously observed effects on axonal extension and dendritic maintenance [2].
  • Kalirin proteins with four different NH(2) termini are generated through the use of five different 5'-ends; three of the proteins differ only at the extreme NH(2) terminus, and one is truncated because translation is initiated at a methionine in the 5th spectrin repeat [3].
  • In primary cultures of neurons, Kalirin-7 is detected in spine-like structures, while other forms of Kalirin are visualized in the cell soma and throughout the neurites [4].
  • Kalirin is a brain-specific protein, first identified through its interaction with peptidylglycine-alpha-amidating monooxygenase [4].
  • P-CIP10 is a 217-kDa cytosolic protein with nine spectrin-like repeats and adjacent Dbl homology and pleckstrin homology domains typical of GDP/GTP exchange factors [5].

Biological context of Kalrn


Anatomical context of Kalrn


Associations of Kalrn with chemical compounds

  • P-CIP2 was homologous to several serine/threonine and dual specificity protein kinases, while P-CIP10 contained spectrin-like repeats [10].
  • Kalirin is a multidomain guanine nucleotide exchange factor for small GTPbinding proteins of the Rho family [6].

Regulatory relationships of Kalrn

  • The presence of Thr1590 in each major Kalirin isoform would allow Cdk5 to regulate Kalirin function throughout development [11].

Other interactions of Kalrn


Analytical, diagnostic and therapeutic context of Kalrn

  • Northern blot analysis indicates brain-specific expression of Duo [13].
  • Western blotting analysis indicated that kalirin-7, the major adult isoform, was a minor component of embryonic kalirin; the main isoform expressed in the embryo was kalirin-9 [14].


  1. Plasticity in hippocampal peptidergic systems induced by repeated electroconvulsive shock. Ma, X.M., Mains, R.E., Eipper, B.A. Neuropsychopharmacology (2002) [Pubmed]
  2. Critical role for Kalirin in nerve growth factor signaling through TrkA. Chakrabarti, K., Lin, R., Schiller, N.I., Wang, Y., Koubi, D., Fan, Y.X., Rudkin, B.B., Johnson, G.R., Schiller, M.R. Mol. Cell. Biol. (2005) [Pubmed]
  3. Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site. Johnson, R.C., Penzes, P., Eipper, B.A., Mains, R.E. J. Biol. Chem. (2000) [Pubmed]
  4. An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction. Penzes, P., Johnson, R.C., Alam, M.R., Kambampati, V., Mains, R.E., Eipper, B.A. J. Biol. Chem. (2000) [Pubmed]
  5. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. Alam, M.R., Johnson, R.C., Darlington, D.N., Hand, T.A., Mains, R.E., Eipper, B.A. J. Biol. Chem. (1997) [Pubmed]
  6. Kalirin expression is regulated by multiple promoters. McPherson, C.E., Eipper, B.A., Mains, R.E. J. Mol. Neurosci. (2004) [Pubmed]
  7. Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat. Ma, X.M., Johnson, R.C., Mains, R.E., Eipper, B.A. J. Comp. Neurol. (2001) [Pubmed]
  8. Multiple novel isoforms of Trio are expressed in the developing rat brain. McPherson, C.E., Eipper, B.A., Mains, R.E. Gene (2005) [Pubmed]
  9. Kalirin, a multifunctional Rho guanine nucleotide exchange factor, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines. Ma, X.M., Huang, J., Wang, Y., Eipper, B.A., Mains, R.E. J. Neurosci. (2003) [Pubmed]
  10. Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme. Alam, M.R., Caldwell, B.D., Johnson, R.C., Darlington, D.N., Mains, R.E., Eipper, B.A. J. Biol. Chem. (1996) [Pubmed]
  11. Regulation of Kalirin by Cdk5. Xin, X., Wang, Y., Ma, X.M., Rompolas, P., Keutmann, H.T., Mains, R.E., Eipper, B.A. J. Cell. Sci. (2008) [Pubmed]
  12. Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms. May, V., Schiller, M.R., Eipper, B.A., Mains, R.E. J. Neurosci. (2002) [Pubmed]
  13. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Colomer, V., Engelender, S., Sharp, A.H., Duan, K., Cooper, J.K., Lanahan, A., Lyford, G., Worley, P., Ross, C.A. Hum. Mol. Genet. (1997) [Pubmed]
  14. Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development. Hansel, D.E., Quiñones, M.E., Ronnett, G.V., Eipper, B.A. J. Histochem. Cytochem. (2001) [Pubmed]
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