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Gene Review

AURKC  -  aurora kinase C

Homo sapiens

Synonyms: AIE2, AIK3, AIRK3, ARK-3, ARK3, ...
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Disease relevance of AURKC


High impact information on AURKC


Biological context of AURKC

  • We therefore suggest that Aurora-C is a novel chromosomal passenger protein that cooperates with Aurora-B to regulate mitotic chromosome dynamics in mammalian cells [4].
  • We present evidence that Aurora-C, like Aurora-B kinase, is a chromosomal passenger protein localizing first to centromeres and then to the midzone of mitotic cells [6].
  • Aurora-C transcript is expressed at a moderate level albeit about an order of magnitude lower than Aurora-B transcript in diploid human fibroblasts [6].
  • Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy [7].
  • Together, our results showed that Aurora-C is a chromosomal passenger protein, which may serve as a key regulator in cell division [7].

Anatomical context of AURKC


Associations of AURKC with chemical compounds

  • The function of Aurora-C kinase, a member of the Aurora kinase family identified in mammals, is currently unknown [6].
  • In order to study the potential role of Aurora-C, we examined the effects of a kinase-deficient (KD) mutant (AurC-KD) in HeLa Tet-Off cells under tetracycline control [7].
  • Aurora-C is the third member of the aurora serine/threonine kinase family and was found only in mammals [8].
  • Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C [11].

Regulatory relationships of AURKC


Other interactions of AURKC

  • Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C [4].
  • Extensive studies on the role of Aurora-A and Aurora-B have revealed distinct localizations and functions in regulating mitotic processes, whereas little is known about Aurora-C [4].
  • Although the physiological function of Aurora-C in somatic cells remains to be clarified, our results, just like for the two other Aurora kinases, raised the question of a role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53 [8].
  • The T171A and T175A mutants, in which threonines located at residues 171 and 175 were replaced by alanines, revealed a significant increase in their kinase activities to phosphorylate ACS-1 (Aurora-C substrate 1) [12].

Analytical, diagnostic and therapeutic context of AURKC


  1. Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues. Ulisse, S., Delcros, J.G., Baldini, E., Toller, M., Curcio, F., Giacomelli, L., Prigent, C., Ambesi-Impiombato, F.S., D'Armiento, M., Arlot-Bonnemains, Y. Int. J. Cancer (2006) [Pubmed]
  2. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Dieterich, K., Soto Rifo, R., Faure, A.K., Hennebicq, S., Ben Amar, B., Zahi, M., Perrin, J., Martinez, D., Sèle, B., Jouk, P.S., Ohlmann, T., Rousseaux, S., Lunardi, J., Ray, P.F. Nat. Genet. (2007) [Pubmed]
  3. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. Wu, J.C., Chen, T.Y., Yu, C.T., Tsai, S.J., Hsu, J.M., Tang, M.J., Chou, C.K., Lin, W.J., Yuan, C.J., Huang, C.Y. J. Biol. Chem. (2005) [Pubmed]
  4. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. Li, X., Sakashita, G., Matsuzaki, H., Sugimoto, K., Kimura, K., Hanaoka, F., Taniguchi, H., Furukawa, K., Urano, T. J. Biol. Chem. (2004) [Pubmed]
  5. The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. Tang, C.J., Chuang, C.K., Hu, H.M., Tang, T.K. J. Biol. Chem. (2001) [Pubmed]
  6. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Sasai, K., Katayama, H., Stenoien, D.L., Fujii, S., Honda, R., Kimura, M., Okano, Y., Tatsuka, M., Suzuki, F., Nigg, E.A., Earnshaw, W.C., Brinkley, W.R., Sen, S. Cell Motil. Cytoskeleton (2004) [Pubmed]
  7. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. Chen, H.L., Tang, C.J., Chen, C.Y., Tang, T.K. J. Biomed. Sci. (2005) [Pubmed]
  8. The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. Dutertre, S., Hamard-Péron, E., Cremet, J.Y., Thomas, Y., Prigent, C. Cell Cycle (2005) [Pubmed]
  9. The human cumulus--oocyte complex gene-expression profile. Assou, S., Anahory, T., Pantesco, V., Le Carrour, T., Pellestor, F., Klein, B., Reyftmann, L., Dechaud, H., De Vos, J., Hamamah, S. Hum. Reprod. (2006) [Pubmed]
  10. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. Kimura, M., Matsuda, Y., Yoshioka, T., Okano, Y. J. Biol. Chem. (1999) [Pubmed]
  11. On the role of aurora-A in centrosome function. Dutertre, S., Descamps, S., Prigent, C. Oncogene (2002) [Pubmed]
  12. Mutational analysis of the phosphorylation sites of the Aie1 (Aurora-C) kinase in vitro. Chen, S.H., Tang, T.K. DNA Cell Biol. (2002) [Pubmed]
  13. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. Bernard, M., Sanseau, P., Henry, C., Couturier, A., Prigent, C. Genomics (1998) [Pubmed]
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