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Gene Review

alphaTub67C  -  alpha-Tubulin at 67C

Drosophila melanogaster

Synonyms: 4t, ALPHA 67C, CG8308, D.m.ALPHA-67C, DTA2, ...
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Disease relevance of alphaTub67C


Psychiatry related information on alphaTub67C

  • The polarity of kinesin's motor activity can be reversed by MT disassembly and interactions between a motor and a MT end can either slow or speed the rate of tubulin depolymerization [2].

High impact information on alphaTub67C


Biological context of alphaTub67C


Anatomical context of alphaTub67C

  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C [8].
  • Tubulin dimer (tT) was purified from turkey erythrocytes [9].
  • As the LG4-LG5 domain of the alpha4 chain is cleaved in vivo from the main body of laminin-8 (alpha4beta1gamma1), we suggest that the heparan sulphate proteoglycan-binding activity of LG4 is significant in modulating the signalling of Wnt, Decapentaplegic and fibroblast growth factors [10].

Associations of alphaTub67C with chemical compounds

  • Imidacloprid bound with very low affinity to the rat alpha4/beta2 nAChR but did so with high affinity to hybrid nAChRs containing Drosophila alpha subunits co-assembled with rat beta2 [11].
  • However, replacement of Glu219 by proline in the YXCC motif in loop C of the chimeric alpha4 subunit resulted in a marked displacement to the left of the concentration-response curve for imidacloprid not seen when an equivalent mutation was made in the alpha4beta2 nAChR [12].
  • The composite data suggest that the woc gene may regulate 20E-dependent alpha-tubulin detyrosination and that microtubules may be involved in sterol transport and sterol utilization in insect [13].

Physical interactions of alphaTub67C

  • To determine the tubulin subunit(s) involved in binding to ncd, mixtures of ncd motor domain and MTs were treated with the zero-length cross-linker 1-ethyl-3-(3-dimethylaminopropyl-carbodiimide) (EDC) [14].

Other interactions of alphaTub67C

  • In contrast to these constitutive genes, the tissue-specific alpha 2 and alpha 4 genes code for tubulins with different structures [15].
  • Thus, both classes of alpha-tubulin isotype present in the mature oocyte, alpha TUB67C and alpha TUB84B/84D, are essential for normal spindle function in early Drosophila development [6].
  • The genetics and cytology of doubly mutant embryos and the molecular defect of NcdD provide evidence for interaction of Ncd with alpha Tub67C in vivo [8].
  • These results imply that a specific alpha-tubulin isoform is required for normal cellular function of a kinesin motor protein [8].
  • The sequence characteristics of misato indicate either that it arose from an ancestral tubulin-like gene, different parts of which underwent convergent evolution to resemble motifs in the conventional tubulins, or that it arose by the capture of motifs from different tubulin genes [16].


  1. Identification of hypomorphic and null alleles of swallow via molecular and phenotypic analyses. Pokrywka, N.J., Meng, L., Debiec, K., Stephenson, E.C. Dev. Genes Evol. (2004) [Pubmed]
  2. Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Lombillo, V.A., Stewart, R.J., McIntosh, J.R. Nature (1995) [Pubmed]
  3. Regulation of tubulin gene expression during embryogenesis in Drosophila melanogaster. Raff, E.C., Fuller, M.T., Kaufman, T.C., Kemphues, K.J., Rudolph, J.E., Raff, R.A. Cell (1982) [Pubmed]
  4. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. Matthies, H.J., Messina, L.G., Namba, R., Greer, K.J., Walker, M.Y., Hawley, R.S. J. Cell Biol. (1999) [Pubmed]
  5. c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB. Postigo, A.A., Sheppard, A.M., Mucenski, M.L., Dean, D.C. EMBO J. (1997) [Pubmed]
  6. A functionally specialized alpha-tubulin is required for oocyte meiosis and cleavage mitoses in Drosophila. Matthews, K.A., Rees, D., Kaufman, T.C. Development (1993) [Pubmed]
  7. alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis. Venkei, Z., Gáspár, I., Tóth, G., Szabad, J. J. Cell. Sci. (2006) [Pubmed]
  8. Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. Komma, D.J., Endow, S.A. J. Cell. Sci. (1997) [Pubmed]
  9. NCD activation of tubulin polymerization. Highsmith, S., Thoene, M., Sablin, E., Polosukhina, K. Biophys. Chem. (2001) [Pubmed]
  10. Mammalian and Drosophila cells adhere to the laminin alpha4 LG4 domain through syndecans, but not glypicans. Yamashita, H., Goto, A., Kadowaki, T., Kitagawa, Y. Biochem. J. (2004) [Pubmed]
  11. The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity. Lansdell, S.J., Millar, N.S. Neuropharmacology (2000) [Pubmed]
  12. Insect-vertebrate chimeric nicotinic acetylcholine receptors identify a region, loop B to the N-terminus of the Drosophila Dalpha2 subunit, which contributes to neonicotinoid sensitivity. Shimomura, M., Satoh, H., Yokota, M., Ihara, M., Matsuda, K., Sattelle, D.B. Neurosci. Lett. (2005) [Pubmed]
  13. Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster. Jin, X., Sun, X., Song, Q. Arch. Insect Biochem. Physiol. (2005) [Pubmed]
  14. ncd and kinesin motor domains interact with both alpha- and beta-tubulin. Walker, R.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins. Theurkauf, W.E., Baum, H., Bo, J., Wensink, P.C. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  16. An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. Miklos, G.L., Yamamoto, M., Burns, R.G., Maleszka, R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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