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Gene Review

NRP1  -  neuropilin 1

Gallus gallus

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High impact information on NRP1


Biological context of NRP1


Anatomical context of NRP1


Other interactions of NRP1

  • Consistent with the insensitivity of trkC(+) collaterals to SEMA3A, these collaterals did not express neuropilin-1, a receptor for SEMA3A [8].

Analytical, diagnostic and therapeutic context of NRP1

  • Arterial-venous differentiation and patterning are controlled by hemodynamic forces, as shown by flow manipulation and in situ hybridization with arterial markers ephrinB2 and neuropilin 1, which show that expression of both mRNAs is not genetically determined but plastic and regulated by flow [9].
  • We investigate the role of a potential guidance factor, neuropilin-1, and use functional knockdown assays, tissue transplantation and in vivo confocal time-lapse imaging to analyze changes in chick cranial neural crest cell migratory patterns [3].
  • Using cocultures composed of tissues derived from chick embryos or neuropilin-1-deficient mice treated with chondroitinase ABC, we show the direct evidence that CSPGs are involved in notochord-derived repulsion for DRG axons [10].
  • Expression of the ligands Sema3A and -3E and the receptors neuropilin Npn-1, -2a and -2b in the chick visual system were analyzed by RT-PCR [11].


  1. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ. Feiner, L., Koppel, A.M., Kobayashi, H., Raper, J.A. Neuron (1997) [Pubmed]
  2. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Moyon, D., Pardanaud, L., Yuan, L., Bréant, C., Eichmann, A. Development (2001) [Pubmed]
  3. In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick. McLennan, R., Kulesa, P.M. Dev. Biol. (2007) [Pubmed]
  4. Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Takagi, S., Kasuya, Y., Shimizu, M., Matsuura, T., Tsuboi, M., Kawakami, A., Fujisawa, H. Dev. Biol. (1995) [Pubmed]
  5. Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse. Bron, R., Eickholt, B.J., Vermeren, M., Fragale, N., Cohen, J. Dev. Dyn. (2004) [Pubmed]
  6. Growth-associated expression of a membrane protein, neuropilin, in Xenopus optic nerve fibers. Fujisawa, H., Takagi, S., Hirata, T. Dev. Neurosci. (1995) [Pubmed]
  7. Neuropilin-1 expression in osteogenic cells: down-regulation during differentiation of osteoblasts into osteocytes. Harper, J., Gerstenfeld, L.C., Klagsbrun, M. J. Cell. Biochem. (2001) [Pubmed]
  8. SEMA3A regulates developing sensory projections in the chicken spinal cord. Fu, S.Y., Sharma, K., Luo, Y., Raper, J.A., Frank, E. J. Neurobiol. (2000) [Pubmed]
  9. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. le Noble, F., Moyon, D., Pardanaud, L., Yuan, L., Djonov, V., Matthijsen, R., Bréant, C., Fleury, V., Eichmann, A. Development (2004) [Pubmed]
  10. Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons. Masuda, T., Fukamauchi, F., Takeda, Y., Fujisawa, H., Watanabe, K., Okado, N., Shiga, T. Mol. Cell. Neurosci. (2004) [Pubmed]
  11. Differential impact of semaphorin 3E and 3A on CNS axons. Steffensky, M., Steinbach, K., Schwarz, U., Schlosshauer, B. Int. J. Dev. Neurosci. (2006) [Pubmed]
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