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Gene Review

Nrp1  -  neuropilin 1

Rattus norvegicus

Synonyms: Neuropilin-1, Vascular endothelial cell growth factor 165 receptor
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Disease relevance of Nrp1


High impact information on Nrp1

  • Neuropilin is a semaphorin III receptor [3].
  • Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165 [4].
  • Collapsin-1 rapidly disrupted the formation of lamellipodia and induced depolymerization of F-actin in an NRP1-dependent manner [4].
  • The larger tumors with induced NRP1 expression were characterized by markedly increased microvessel density, increased proliferating EC, dilated blood vessels, and notably less tumor cell apoptosis compared to noninduced controls [5].
  • When rats injected with AT2.1/NRP1 tumor cells were fed Dox, NRP1 synthesis was induced in vivo and AT2.1 cell tumor size was increased 2.5- to 7-fold in a 3-4 wk period compared to controls [5].

Biological context of Nrp1


Anatomical context of Nrp1


Associations of Nrp1 with chemical compounds


Other interactions of Nrp1


Analytical, diagnostic and therapeutic context of Nrp1


  1. Peripheral, but not central, axotomy induces neuropilin-1 mRNA expression in adult large diameter primary sensory neurons. Gavazzi, I., Stonehouse, J., Sandvig, A., Reza, J.N., Appiah-Kubi, L.S., Keynes, R., Cohen, J. J. Comp. Neurol. (2000) [Pubmed]
  2. Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat. Zhang, Z.G., Tsang, W., Zhang, L., Powers, C., Chopp, M. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  3. Neuropilin is a semaphorin III receptor. Kolodkin, A.L., Levengood, D.V., Rowe, E.G., Tai, Y.T., Giger, R.J., Ginty, D.D. Cell (1997) [Pubmed]
  4. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. Miao, H.Q., Soker, S., Feiner, L., Alonso, J.L., Raper, J.A., Klagsbrun, M. J. Cell Biol. (1999) [Pubmed]
  5. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. Miao, H.Q., Lee, P., Lin, H., Soker, S., Klagsbrun, M. FASEB J. (2000) [Pubmed]
  6. Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. Pasterkamp, R.J., De Winter, F., Holtmaat, A.J., Verhaagen, J. J. Neurosci. (1998) [Pubmed]
  7. Evidence that Sema3A and Sema3F regulate the migration of GABAergic neurons in the developing neocortex. Tamamaki, N., Fujimori, K., Nojyo, Y., Kaneko, T., Takauji, R. J. Comp. Neurol. (2003) [Pubmed]
  8. Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors. Ostendorf, T., Van Roeyen, C., Westenfeld, R., Gawlik, A., Kitahara, M., De Heer, E., Kerjaschki, D., Floege, J., Ketteler, M. J. Am. Soc. Nephrol. (2004) [Pubmed]
  9. Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates semaphorin3a/collapsin-1-induced growth cone collapse by small diameter sensory afferents. Reza, J.N., Gavazzi, I., Cohen, J. Mol. Cell. Neurosci. (1999) [Pubmed]
  10. Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS. Pasterkamp, R.J., Giger, R.J., Ruitenberg, M.J., Holtmaat, A.J., De Wit, J., De Winter, F., Verhaagen, J. Mol. Cell. Neurosci. (1999) [Pubmed]
  11. Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy. Lindholm, T., Sköld, M.K., Suneson, A., Carlstedt, T., Cullheim, S., Risling, M. Neuroreport (2004) [Pubmed]
  12. Regulation of neuropilin 1 by spinal cord injury in adult rats. Agudo, M., Robinson, M., Cafferty, W., Bradbury, E.J., Kilkenny, C., Hunt, S.P., McMahon, S.B. Mol. Cell. Neurosci. (2005) [Pubmed]
  13. The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Shearer, M.C., Niclou, S.P., Brown, D., Asher, R.A., Holtmaat, A.J., Levine, J.M., Verhaagen, J., Fawcett, J.W. Mol. Cell. Neurosci. (2003) [Pubmed]
  14. Differential expression and regulation of the vascular endothelial growth factor receptors neuropilin-1 and neuropilin-2 in rat uterus. Pavelock, K., Braas, K., Ouafik, L., Osol, G., May, V. Endocrinology (2001) [Pubmed]
  15. Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix. De Wit, J., De Winter, F., Klooster, J., Verhaagen, J. Mol. Cell. Neurosci. (2005) [Pubmed]
  16. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Li, P., Rossman, T.G. Toxicol. Sci. (2001) [Pubmed]
  17. Gene expression profiling following chronic NMDA receptor blockade-induced learning deficits in rats. O'Donnell, J., Stemmelin, J., Nitta, A., Brouillette, J., Quirion, R. Synapse (2003) [Pubmed]
  18. Expression of angiogenic factors during distraction osteogenesis. Pacicca, D.M., Patel, N., Lee, C., Salisbury, K., Lehmann, W., Carvalho, R., Gerstenfeld, L.C., Einhorn, T.A. Bone (2003) [Pubmed]
  19. Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Sköld, M., Cullheim, S., Hammarberg, H., Piehl, F., Suneson, A., Lake, S., Sjögren, A., Walum, E., Risling, M. Eur. J. Neurosci. (2000) [Pubmed]
  20. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Tsim, T.Y., Wong, E.Y., Leung, M.S., Wong, C.C. Neuroscience (2004) [Pubmed]
  21. Vascular endothelial growth factor and angiopoietin in liver regeneration. Kraizer, Y., Mawasi, N., Seagal, J., Paizi, M., Assy, N., Spira, G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  22. Microarray analysis of selected genes in neural stem and progenitor cells. Luo, Y., Cai, J., Liu, Y., Xue, H., Chrest, F.J., Wersto, R.P., Rao, M. J. Neurochem. (2002) [Pubmed]
  23. Sema3A and neuropilin-1 expression and distribution in rat white adipose tissue. Giordano, A., Cesari, P., Capparuccia, L., Castellucci, M., Cinti, S. J. Neurocytol. (2003) [Pubmed]
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