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Gene Review

CSRP1  -  cysteine and glycine-rich protein 1

Gallus gallus

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High impact information on CSRP1


Biological context of CSRP1


Anatomical context of CSRP1


Associations of CSRP1 with chemical compounds

  • Each of the three vertebrate CRP isoforms characterized to date is composed of two copies of the zinc-binding LIM domain with associated glycine-rich repeats [5].
  • Mutant receptor proteins which retained the highly conserved cysteine-rich (C1) region were able to bind to DNA-cellulose, although removal of 290 amino acids from the C-terminus resulted in reduced affinity for DNA [8].
  • The deduced amino acid sequence comprises a cysteine-rich extracellular domain, a single hydrophobic transmembrane domain, and a cytoplasmic serine/threonine kinase domain [9].
  • Precursor-product relationship between chicken vitellogenin and the yolk proteins: the 40 kDa yolk plasma glycoprotein is derived from the C-terminal cysteine-rich domain of vitellogenin II [10].

Physical interactions of CSRP1


Other interactions of CSRP1

  • It closely resembles the mammalian so-called very low density lipoprotein receptors, in that its aminoterminal ligand binding domain consists of a cluster of 8 cysteine-rich repeats [11].

Analytical, diagnostic and therapeutic context of CSRP1

  • Examination of a number of chick embryonic tissues by Western immunoblot analysis reveals that cCRP exhibits tissue-specific expression. cCRP is most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine [3].
  • Primary sequence analyses have revealed that both zyxin and CRP1 exhibit multiple copies of a structural motif called the LIM domain [6].


  1. The chicken neural extracellular matrix molecule restrictin: similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs. Nörenberg, U., Wille, H., Wolff, J.M., Frank, R., Rathjen, F.G. Neuron (1992) [Pubmed]
  2. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. Pomiès, P., Louis, H.A., Beckerle, M.C. J. Cell Biol. (1997) [Pubmed]
  3. Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. Crawford, A.W., Pino, J.D., Beckerle, M.C. J. Cell Biol. (1994) [Pubmed]
  4. Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family. Bujo, H., Hermann, M., Kaderli, M.O., Jacobsen, L., Sugawara, S., Nimpf, J., Yamamoto, T., Schneider, W.J. EMBO J. (1994) [Pubmed]
  5. Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. Louis, H.A., Pino, J.D., Schmeichel, K.L., Pomiès, P., Beckerle, M.C. J. Biol. Chem. (1997) [Pubmed]
  6. LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. Schmeichel, K.L., Beckerle, M.C. Biochem. J. (1998) [Pubmed]
  7. Cysteine-rich protein 1 (CRP1) regulates actin filament bundling. Tran, T.C., Singleton, C., Fraley, T.S., Greenwood, J.A. BMC Cell Biol. (2005) [Pubmed]
  8. Structure-function properties of the chicken progesterone receptor A synthesized from complementary deoxyribonucleic acid. Carson, M.A., Tsai, M.J., Conneely, O.M., Maxwell, B.L., Clark, J.H., Dobson, A.D., Elbrecht, A., Toft, D.O., Schrader, W.T., O'Malley, B.W. Mol. Endocrinol. (1987) [Pubmed]
  9. A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta. Sumitomo, S., Saito, T., Nohno, T. DNA Seq. (1993) [Pubmed]
  10. Precursor-product relationship between chicken vitellogenin and the yolk proteins: the 40 kDa yolk plasma glycoprotein is derived from the C-terminal cysteine-rich domain of vitellogenin II. Yamamura, J., Adachi, T., Aoki, N., Nakajima, H., Nakamura, R., Matsuda, T. Biochim. Biophys. Acta (1995) [Pubmed]
  11. Evolution of oogenesis: the receptor for vitellogenin from the rainbow trout. Davail, B., Pakdel, F., Bujo, H., Perazzolo, L.M., Waclawek, M., Schneider, W.J., Le Menn, F. J. Lipid Res. (1998) [Pubmed]
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