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Gene Review

APOB  -  apolipoprotein B (including Ag(x) antigen)

Sus scrofa

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Disease relevance of APOB


High impact information on APOB


Biological context of APOB


Anatomical context of APOB


Associations of APOB with chemical compounds


Physical interactions of APOB

  • We have previously shown that addition of lipoprotein lipase (LPL) markedly increased binding of apolipoprotein B (apoB)-containing lipoproteins to an endothelial cell-derived matrix, and this enhanced lipoprotein binding was inhibited by apoE [20].

Regulatory relationships of APOB


Other interactions of APOB

  • As expected based on the observation of extensive linkage conservation and based on the previous assignment of the malate dehydrogenase locus (MDH1) in swine, APOB maps to chromosome 3, specifically to region 3q24-qter [21].

Analytical, diagnostic and therapeutic context of APOB


  1. Molecular genetics of the apolipoprotein B gene in pigs in relation to atherosclerosis. Maeda, N., Ebert, D.L., Doers, T.M., Newman, M., Hasler-Rapacz, J., Attie, A.D., Rapacz, J., Smithies, O. Gene (1988) [Pubmed]
  2. Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype. Nichols, T.C., Bellinger, D.A., Davis, K.E., Koch, G.G., Reddick, R.L., Read, M.S., Rapacz, J., Hasler-Rapacz, J., Brinkhous, K.M., Griggs, T.R. Am. J. Pathol. (1992) [Pubmed]
  3. Familial hypercholesterolemia associated with coronary atherosclerosis in swine bearing different alleles for apolipoprotein B. Prescott, M.F., Hasler-Rapacz, J., von Linden-Reed, J., Rapacz, J. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  4. Selective removal of apolipoprotein B-containing serum lipoproteins from blood plasma. Stoffel, W., Demant, T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. Defective receptor binding of low density lipoprotein from pigs possessing mutant apolipoprotein B alleles. Lowe, S.W., Checovich, W.J., Rapacz, J., Attie, A.D. J. Biol. Chem. (1988) [Pubmed]
  6. The HMG-CoA reductase inhibitor atorvastatin increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs. Burnett, J.R., Barrett, P.H., Vicini, P., Miller, D.B., Telford, D.E., Kleinstiver, S.J., Huff, M.W. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  7. Plasma lipoprotein profile and lipolytic activities in response to the substitution of lean white fish for other animal protein sources in premenopausal women. Gascon, A., Jacques, H., Moorjani, S., Deshaies, Y., Brun, L.D., Julien, P. Am. J. Clin. Nutr. (1996) [Pubmed]
  8. Abundant (A)n.(T)n mononucleotide repeats in the pig genome: linkage mapping of the porcine APOB, FSA, ALOX12, PEPN and RLN loci. Ellegren, H. Anim. Genet. (1993) [Pubmed]
  9. Mapping of the porcine apolipoprotein B (APOB) gene to chromosome 3 by fluorescence in situ hybridization. Sarmiento, U.M., Kadavil, K. Mamm. Genome (1993) [Pubmed]
  10. Apolipoprotein B messenger RNA editing is developmentally regulated in pig small intestine: nucleotide comparison of apolipoprotein B editing regions in five species. Teng, B., Black, D.D., Davidson, N.O. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  11. Citrus pectin and cholesterol interact to regulate hepatic cholesterol homeostasis and lipoprotein metabolism: a dose-response study in guinea pigs. Fernandez, M.L., Sun, D.M., Tosca, M.A., McNamara, D.J. Am. J. Clin. Nutr. (1994) [Pubmed]
  12. Apolipoprotein B accumulation and development of foam cell lesions in coronary arteries of hypercholesterolemic swine. Yamauchi, Y., Hoff, H.F. Lab. Invest. (1984) [Pubmed]
  13. Quantitation of apolipoprotein B in aortas of hypercholesterolemic swine. Hoff, H.F., Gerrity, R.G., Naito, H.K., Dusek, D.M. Lab. Invest. (1983) [Pubmed]
  14. Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation. Takatsu, H., Tasaki, H., Kim, H.N., Ueda, S., Tsutsui, M., Yamashita, K., Toyokawa, T., Morimoto, Y., Nakashima, Y., Adachi, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  15. Lipoprotein and apolipoprotein secretion by a newborn piglet intestinal cell line (IPEC-1). Gonzalez-Vallina, R., Wang, H., Zhan, R., Berschneider, H.M., Lee, R.M., Davidson, N.O., Black, D.D. Am. J. Physiol. (1996) [Pubmed]
  16. Inhibition of HMG-CoA reductase by atorvastatin decreases both VLDL and LDL apolipoprotein B production in miniature pigs. Burnett, J.R., Wilcox, L.J., Telford, D.E., Kleinstiver, S.J., Barrett, P.H., Newton, R.S., Huff, M.W. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  17. Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. Qureshi, A.A., Qureshi, N., Hasler-Rapacz, J.O., Weber, F.E., Chaudhary, V., Crenshaw, T.D., Gapor, A., Ong, A.S., Chong, Y.H., Peterson, D. Am. J. Clin. Nutr. (1991) [Pubmed]
  18. The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs. Burnett, J.R., Wilcox, L.J., Telford, D.E., Kleinstiver, S.J., Barrett, P.H., Newton, R.S., Huff, M.W. Endocrinology (1999) [Pubmed]
  19. Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs. Burnett, J.R., Wilcox, L.J., Telford, D.E., Kleinstiver, S.J., Barrett, P.H., Newton, R.S., Huff, M.W. J. Lipid Res. (1999) [Pubmed]
  20. Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix. Saxena, U., Auerbach, B.J., Ferguson, E., Wölle, J., Marcel, Y.L., Weisgraber, K.H., Hegele, R.A., Bisgaier, C.L. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  21. Assignment of the pig apolipoprotein B locus (APOB) to chromosome region 3q24-qter. Solinas, S., Hasler-Rapacz, J., Maeda, N., Rapacz, J., Fries, R. Anim. Genet. (1992) [Pubmed]
  22. Bi-PASA genotyping of a new polymorphism in the APOB gene shows no evidence for an association with fatness in pigs. Jiang, Z.H., Gibson, J.P. Anim. Genet. (1999) [Pubmed]
  23. The distribution and partial characterization of the serum apolipoproteins in the guinea pig. Chapman, M.J., Mills, G.L., Ledford, J.H. Biochem. J. (1975) [Pubmed]
  24. Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. Vergara-Jimenez, M., Conde, K., Erickson, S.K., Fernandez, M.L. J. Lipid Res. (1998) [Pubmed]
  25. Concentrations and compositions of plasma lipoprotein subfractions of Lpb5-Lpu1 homozygous and heterozygous swine with hypercholesterolemia. Lee, D.M., Mok, T., Hasler-Rapacz, J., Rapacz, J. J. Lipid Res. (1990) [Pubmed]
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