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Chemical Compound Review

CHEBI:11814     4-[2-[3-[[(2R)-4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: KST-1A1759, AR-1A7374, AC1L3M7S, AC1Q5VD4, 1553-55-5, ...
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Disease relevance of EINECS 216-301-7


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Chemical compound and disease context of EINECS 216-301-7


Biological context of EINECS 216-301-7


Anatomical context of EINECS 216-301-7


Associations of EINECS 216-301-7 with other chemical compounds


Gene context of EINECS 216-301-7


Analytical, diagnostic and therapeutic context of EINECS 216-301-7


  1. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Ho, R.H., Tirona, R.G., Leake, B.F., Glaeser, H., Lee, W., Lemke, C.J., Wang, Y., Kim, R.B. Gastroenterology (2006) [Pubmed]
  2. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Kusama, T., Mukai, M., Iwasaki, T., Tatsuta, M., Matsumoto, Y., Akedo, H., Inoue, M., Nakamura, H. Gastroenterology (2002) [Pubmed]
  3. Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Kamiński, R., Kozar, K., Kopeć, M., Basak, G., Skierski, J.S., Koronkiewicz, M., Jakóbisiak, M., Gołab, J. Gastroenterology (2002) [Pubmed]
  4. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. Agarwal, B., Rao, C.V., Bhendwal, S., Ramey, W.R., Shirin, H., Reddy, B.S., Holt, P.R. Gastroenterology (1999) [Pubmed]
  5. Effects of alcohol and fluvastatin on lipid metabolism and hepatic function. Smit, J.W., Wijnne, H.J., Schobben, F., Sitsen, A., De Bruin, T.W., Erkelens, D.W. Ann. Intern. Med. (1995) [Pubmed]
  6. The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. Pooler, A.M., Xi, S.C., Wurtman, R.J. J. Neurochem. (2006) [Pubmed]
  7. Effect of pravastatin on outcomes after cardiac transplantation. Kobashigawa, J.A., Katznelson, S., Laks, H., Johnson, J.A., Yeatman, L., Wang, X.M., Chia, D., Terasaki, P.I., Sabad, A., Cogert, G.A. N. Engl. J. Med. (1995) [Pubmed]
  8. Effect of an inhibitor of 3-hydroxy-3-methyglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10-levels in patients with familial hypercholesterolemia. Mabuchi, H., Haba, T., Tatami, R., Miyamoto, S., Sakai, Y., Wakasugi, T., Watanabe, A., Koizumi, J., Takeda, R. N. Engl. J. Med. (1981) [Pubmed]
  9. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
  10. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. Wang, P.S., Solomon, D.H., Mogun, H., Avorn, J. JAMA (2000) [Pubmed]
  11. HMG-CoA reductase inhibitors and the risk of fractures. Meier, C.R., Schlienger, R.G., Kraenzlin, M.E., Schlegel, B., Jick, H. JAMA (2000) [Pubmed]
  12. Inhibition of pancreatic adenocarcinoma cell growth by lovastatin. Sumi, S., Beauchamp, R.D., Townsend, C.M., Uchida, T., Murakami, M., Rajaraman, S., Ishizuka, J., Thompson, J.C. Gastroenterology (1992) [Pubmed]
  13. Comparison of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma cells grown in vivo and in vitro. Beirne, O.R., Watson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  14. Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in minimal deviation hepatoma 7288C. Immunological measurements in hepatoma tissue culture cells. Beirne, O.R., Heller, R., Watson, J.A. J. Biol. Chem. (1977) [Pubmed]
  15. Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modification. Jordan-Starck, T.C., Rodwell, V.W. J. Biol. Chem. (1989) [Pubmed]
  16. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. Hidaka, Y., Hotta, H., Nagata, Y., Iwasawa, Y., Horie, M., Kamei, T. J. Biol. Chem. (1991) [Pubmed]
  17. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. Aktas, O., Waiczies, S., Smorodchenko, A., Dorr, J., Seeger, B., Prozorovski, T., Sallach, S., Endres, M., Brocke, S., Nitsch, R., Zipp, F. J. Exp. Med. (2003) [Pubmed]
  18. Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. Tabas, I., Weiland, D.A., Tall, A.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  19. Cholesterol homeostasis in the rat with a portacaval anastomosis. Proia, A., McNamara, D.J., Edwards, K.D., Ahrens, E.H. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  20. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. Carlberg, M., Dricu, A., Blegen, H., Wang, M., Hjertman, M., Zickert, P., Höög, A., Larsson, O. J. Biol. Chem. (1996) [Pubmed]
  21. Phosphorylation of Ser871 impairs the function of His865 of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase. Omkumar, R.V., Rodwell, V.W. J. Biol. Chem. (1994) [Pubmed]
  22. Role of lipoprotein-X in the pathogenesis of cholestatic hypercholesterolemia. Uptake of lipoprotein-X and its effect on 3-hydroxy-3-methylglutaryl coenzyme A reductase and chylomicron remnant removal in human fibroblasts, lymphocytes, and in the rat. Walli, A.K., Seidel, D. J. Clin. Invest. (1984) [Pubmed]
  23. HMG CoA reductase inhibitor (statin) and aortic valve calcium. Shavelle, D.M., Takasu, J., Budoff, M.J., Mao, S., Zhao, X.Q., O'Brien, K.D. Lancet (2002) [Pubmed]
  24. Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleus. Wright, R., Basson, M., D'Ari, L., Rine, J. J. Cell Biol. (1988) [Pubmed]
  25. Genetic complementation analysis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency in cultured fibroblasts. Sovik, O., Sweetman, L., Gibson, K.M., Nyhan, W.L. Am. J. Hum. Genet. (1984) [Pubmed]
  26. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Guijarro, C., Blanco-Colio, L.M., Ortego, M., Alonso, C., Ortiz, A., Plaza, J.J., Díaz, C., Hernández, G., Egido, J. Circ. Res. (1998) [Pubmed]
  27. Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster. Horton, J.D., Cuthbert, J.A., Spady, D.K. J. Clin. Invest. (1994) [Pubmed]
  28. Lovastatin decreases coenzyme Q levels in rats. Willis, R.A., Folkers, K., Tucker, J.L., Ye, C.Q., Xia, L.J., Tamagawa, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Greenspan, M.D., Yudkovitz, J.B., Lo, C.Y., Chen, J.S., Alberts, A.W., Hunt, V.M., Chang, M.N., Yang, S.S., Thompson, K.L., Chiang, Y.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  30. Loss of transcriptional activation of three sterol-regulated genes in mutant hamster cells. Evans, M.J., Metherall, J.E. Mol. Cell. Biol. (1993) [Pubmed]
  31. Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. Lee, S.J., Ha, M.J., Lee, J., Nguyen, P., Choi, Y.H., Pirnia, F., Kang, W.K., Wang, X.F., Kim, S.J., Trepel, J.B. J. Biol. Chem. (1998) [Pubmed]
  32. Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes. Basson, M.E., Moore, R.L., O'Rear, J., Rine, J. Genetics (1987) [Pubmed]
  33. Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis. Vaziri, N.D., Sato, T., Liang, K. Kidney Int. (2003) [Pubmed]
  34. Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy. Wheeler, M.D., Smutney, O.M., Check, J.F., Rusyn, I., Schulte-Hermann, R., Thurman, R.G. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  35. Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression. Leon, C., Wasan, K.M., Sachs-Barrable, K., Johnston, T.P. Pharm. Res. (2006) [Pubmed]
  36. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Han, K.H., Ryu, J., Hong, K.H., Ko, J., Pak, Y.K., Kim, J.B., Park, S.W., Kim, J.J. Circulation (2005) [Pubmed]
  37. Antiatherothrombotic properties of statins: implications for cardiovascular event reduction. Rosenson, R.S., Tangney, C.C. JAMA (1998) [Pubmed]
  38. Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA. Chin, D.J., Luskey, K.L., Faust, J.R., MacDonald, R.J., Brown, M.S., Goldstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  39. Lipoprotein regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rat liver cell cultures. Breslow, J.L., Lothrop, D.A., Clowes, A.W., Lux, S.E. J. Biol. Chem. (1977) [Pubmed]
  40. Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Impact on activity and degradation of the enzyme. Parker, R.A., Miller, S.J., Gibson, D.M. J. Biol. Chem. (1989) [Pubmed]
  41. Squalene synthase-deficient mutant of Chinese hamster ovary cells. Bradfute, D.L., Silva, C.J., Simoni, R.D. J. Biol. Chem. (1992) [Pubmed]
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