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Gene Review

CD80  -  CD80 molecule

Sus scrofa

 
 
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Disease relevance of CD80

 

High impact information on CD80

  • We hypothesize that expression of CD80 and/or CD86 on porcine cells may also play a role in NK cell activation as human NK cells express a variant of CD28 [2].
  • Differentiation was characterized by down-regulation of CD14, MHC Ags, the monocytic SWC1 marker, and p53; concomitant up-regulation of the SWC9 macrophage marker, a putative porcine CD80 (detected with anti-human CD80 Ab), and acid phosphatase secretion were also characteristic [3].
  • However, there was no modulation of DC surface major histocompatibility complex class I and class II, CD80/86, CD25, CD16, or CD14 [4].
  • DC activation was monitored in terms of MHC class II and CD80/86 upregulation, as well as the production of type I interferon (IFN-alpha/beta) [5].
  • The purpose of this study was to investigate the functional interaction between porcine CD80 and human T cells using the full-length clone of porcine CD80 [6].
 

Biological context of CD80

  • RESULTS: We cloned and determined the complete nucleotide sequence for the transmembrane form of porcine CD80 [6].
  • Polymerase chain reaction-amplified cDNA coding for the open reading frame of the porcine CD80 transmembrane form was subcloned into an expression vector and then transfected into Chinese hamster ovary (CHO) cells [6].
  • Comparison of the amino acid sequence of the TM form of ovine CD80 with the sequence of cattle, swine and human CD80 indicated that the deduced protein had a higher degree of similarity to cattle (87% of amino acid identity) than to pig (68%) and human sequence (53% of homology) [7].
 

Anatomical context of CD80

  • These differences were markedly potentiated in gamma interferon (IFN-gamma)-treated macrophages, in which LPS potently induced IL-12 and CD80-CD86 expression [8].
  • The blood DC specialized in T-cell stimulation were major histocompatibility complex (MHC) class II+, CD80/86+, CD1+/-, CD4-, and in contrast to monocytes CD14-. A CD16- and a CD16+ subset could be discriminated [9].
  • OprI activated porcine monocyte-derived dendritic cells (MoDC), upregulating CD80/86 and MHC class II expression, as well as pro-inflammatory cytokines [10].
  • These cells exhibit higher expression of porcine MHC class II (SLAII) and CD80/86 antigens as compared to macrophage/monocyte cells [11].
  • Monocyte differentiation into DC is accompanied by an up-regulation of the expression of swine leukocyte antigen (SLA) I, SLA II and CD80/86 molecules, and a decrease in the expression of CD14, CD16 and CD163 [12].
 

Associations of CD80 with chemical compounds

 

Other interactions of CD80

  • Differential regulation of macrophage interleukin-1 (IL-1), IL-12, and CD80-CD86 by two bacterial toxins [8].
  • Differences in the expression of adhesion and costimulatory molecules are also patent, with a progressive increase in the expression of CD11a, wCD11R1, CD29, CD49d, CD61, CD1a and CD80/86, and a concomitant decrease in that of wCD11R2 [14].
  • Granulocyte-macrophage colony-stimulating factor and interleukin-3 were survival factors for this DC subset, and culture induced an up-regulation of MHC class II and CD80/86 [9].
 

Analytical, diagnostic and therapeutic context of CD80

  • In tissues, RT-PCR using primers for the TM and the sCD80 transcripts indicated that the expression of both CD80 transcripts was almost exclusively expressed in the hematolymphoid system, with the exception of the uterus [7].

References

  1. CD80/86 and Th1 cytokine expression in intestinal graft following reperfusion and endotoxemia. Wada, M., Amae, S., Ishii, T., Sano, N., Sasaki, H., Nio, M., Hayashi, Y., Ohi, R. Transplant. Proc. (2001) [Pubmed]
  2. Human NK cell-mediated cytotoxicity triggered by CD86 and Gal alpha 1,3-Gal is inhibited in genetically modified porcine cells. Costa, C., Barber, D.F., Fodor, W.L. J. Immunol. (2002) [Pubmed]
  3. Modulation of monocytic cell activity and virus susceptibility during differentiation into macrophages. Basta, S., Knoetig, S.M., Spagnuolo-Weaver, M., Allan, G., McCullough, K.C. J. Immunol. (1999) [Pubmed]
  4. Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. Vincent, I.E., Carrasco, C.P., Herrmann, B., Meehan, B.M., Allan, G.M., Summerfield, A., McCullough, K.C. J. Virol. (2003) [Pubmed]
  5. Double-stranded secondary structures on mRNA induce type I interferon (IFN alpha/beta) production and maturation of mRNA-transfected monocyte-derived dendritic cells. Ceppi, M., Ruggli, N., Tache, V., Gerber, H., McCullough, K.C., Summerfield, A. The journal of gene medicine. (2005) [Pubmed]
  6. The functional roles of porcine CD80 molecule and its ability to stimulate and regulate human anti-pig cellular response. Wada, M., Amae, S., Sasaki, H., Ishii, T., Sano, N., Nio, M., Hayashi, Y., Ohi, R. Transplantation (2003) [Pubmed]
  7. Molecular cloning and mRNA tissue-expression of two isoforms of the ovine costimulatory molecule CD80 (B7-1). Terzo, E.A., Alzueta, M., Amorena, B., de Andrés, D.F., de la Lastra, J.M. Vet. Immunol. Immunopathol. (2005) [Pubmed]
  8. Differential regulation of macrophage interleukin-1 (IL-1), IL-12, and CD80-CD86 by two bacterial toxins. Foss, D.L., Zilliox, M.J., Murtaugh, M.P. Infect. Immun. (1999) [Pubmed]
  9. Porcine peripheral blood dendritic cells and natural interferon-producing cells. Summerfield, A., Guzylack-Piriou, L., Schaub, A., Carrasco, C.P., Tâche, V., Charley, B., McCullough, K.C. Immunology (2003) [Pubmed]
  10. Efficacy and functionality of lipoprotein OprI from Pseudomonas aeruginosa as adjuvant for a subunit vaccine against classical swine fever. Rau, H., Revets, H., Cornelis, P., Titzmann, A., Ruggli, N., McCullough, K.C., Summerfield, A. Vaccine (2006) [Pubmed]
  11. Characterization and functional analysis of skin-derived dendritic cells from swine without a requirement for in vitro propagation. Bautista, E.M., Gregg, D., Golde, W.T. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  12. In vitro differentiation of porcine blood CD163- and CD163+ monocytes into functional dendritic cells. Chamorro, S., Revilla, C., Gómez, N., Alvarez, B., Alonso, F., Ezquerra, A., Domínguez, J. Immunobiology (2004) [Pubmed]
  13. Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. Tadaki, D.K., Williams, A., Lee, K.P., Kirk, A.D., Harlan, D.M. Xenotransplantation (2003) [Pubmed]
  14. Phenotypic and functional heterogeneity of porcine blood monocytes and its relation with maturation. Chamorro, S., Revilla, C., Alvarez, B., Alonso, F., Ezquerra, A., Domínguez, J. Immunology (2005) [Pubmed]
 
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