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Gene Review

tnc  -  tenascin C

Xenopus laevis

Synonyms: tenascin-C, tn
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High impact information on TN

  • To identify changes in gene expression that occur in chicken embryo brain (CEB) cells as a consequence of their binding to the extracellular matrix molecule cytotactin/tenascin (CT/TN), a subtractive hybridization cloning strategy was employed [1].
  • No TN mRNA could be detected in lateral plate mesoderm, but expression was detectable beneath tail fin epidermis [2].
  • TN expression is, however, elicited in response to isolated dorsal vegetal blastomeres and in response to high concentrations of activin, both of which treatments lead to formation of muscle and/or notochord [2].
  • We report that TN transcripts are principally expressed in cells dispersed around the neural tube and notochord as well as in myotome and sclerotome cells [2].
  • In a second series of experiments, we studied the expression of TN mRNA and protein in combinations between animal and vegetal stage-6 blastomeres and in stage-8 blastula animal caps treated with activin A or basic fibroblastic growth factor (b-FGF) [2].

Biological context of TN


Anatomical context of TN


Associations of TN with chemical compounds


Other interactions of TN


Analytical, diagnostic and therapeutic context of TN

  • We have studied the spatial and temporal expression of TN mRNA in tailbud-stage embryos by RNAase protection and in situ hybridization using a cDNA probe for Xenopus TN obtained by PCR amplification [2].
  • Tenascin was purified by affinity chromatography on a column of the monoclonal antibody mAb TnM1; the molecule eluted from this column has a relative molecular mass of 210 kDa after reduction [7].
  • Immunogold electron microscopy revealed the presence of Tn throughout the ependymoglial cells, particularly near and along the plasma membrane of radial processes surrounding axons, especially growth cones [9].


  1. Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells. Tranque, P., Crossin, K.L., Cirelli, C., Edelman, G.M., Mauro, V.P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Expression of tenascin mRNA in mesoderm during Xenopus laevis embryogenesis: the potential role of mesoderm patterning in tenascin regionalization. Umbhauer, M., Riou, J.F., Spring, J., Smith, J.C., Boucaut, J.C. Development (1992) [Pubmed]
  3. Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage. Tucker, R., Drabikowski, K., Hess, J., Ferralli, J., Chiquet-Ehrismann, R., Adams, J. BMC Evol. Biol. (2006) [Pubmed]
  4. The distribution of fibronectin and tenascin along migratory pathways of the neural crest in the trunk of amphibian embryos. Epperlein, H.H., Halfter, W., Tucker, R.P. Development (1988) [Pubmed]
  5. Origin and distribution of enteric neurones in Xenopus. Epperlein, H.H., Krotoski, D., Halfter, W., Frey, A. Anat. Embryol. (1990) [Pubmed]
  6. The distribution of tenascin coincides with pathways of neural crest cell migration. Mackie, E.J., Tucker, R.P., Halfter, W., Chiquet-Ehrismann, R., Epperlein, H.H. Development (1988) [Pubmed]
  7. Purification and partial characterization of Xenopus laevis tenascin from the XTC cell line. Riou, J.F., Alfandari, D., Eppe, M., Tacchetti, C., Chiquet, M., Boucaut, J.C., Thiery, J.P., Levi, G. FEBS Lett. (1991) [Pubmed]
  8. Control of somitic expression of tenascin in Xenopus embryos by myogenic factors and Brachyury. Umbhauer, M., Riou, J.F., Smith, J.C., Boucaut, J.C. Dev. Dyn. (1994) [Pubmed]
  9. Tenascin expression in developing, adult and regenerating caudal spinal cord in the urodele amphibians. Caubit, X., Riou, J.F., Coulon, J., Arsanto, J.P., Benraiss, A., Boucaut, J.C., Thouveny, Y. Int. J. Dev. Biol. (1994) [Pubmed]
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