The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CSN2  -  casein beta

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CSN2


High impact information on CSN2

  • The synthetic peptide NH2-Tyr-Pro-Phe-Pro-CONH2 (morphiceptin), which is the amide of a fragment of the milk protein beta-casein, has morphinelike activities and is highly specific for morphine (mu) receptors but not for enkephalin (delta) receptors [2].
  • The primary site of amine incorporation by factor XIIIa in beta-casein was identified as glutamine 167 [3].
  • The validity of the procedure is demonstrated by the preparation of photosensitive derivatives of substance P and glucagon 1-6 and in the cleavable covalent cross-linking of guanidinated beta-casein [4].
  • Evidence for intermolecular cross-linking through polyamines with both the liver enzyme and thrombin-activated human plasma blood coagulation factor XIII was obtained by the use of a guanidinated derivative of beta-casein [5].
  • This suggests that the regulation of the beta-lactoglobulin gene is distinct from that of beta-casein and WAP [6].

Biological context of CSN2


Anatomical context of CSN2


Associations of CSN2 with chemical compounds


Analytical, diagnostic and therapeutic context of CSN2


  1. Purification of porcine beta-casein, N-terminal sequence, quantification in mastitic milk. Kauf, A.C., Kensinger, R.S. J. Anim. Sci. (2002) [Pubmed]
  2. Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors. Chang, K.J., Lillian, A., Hazum, E., Cuatrecasas, P., Chang, J.K. Science (1981) [Pubmed]
  3. Structural features of glutamine substrates for human plasma factor XIIIa (activated blood coagulation factor XIII). Gorman, J.J., Folk, J.E. J. Biol. Chem. (1980) [Pubmed]
  4. Transglutaminase amine substrates for photochemical labeling and cleavable cross-linking of proteins. Gorman, J.J., Folk, J.E. J. Biol. Chem. (1980) [Pubmed]
  5. Transglutaminase-catalyzed cross-linking through diamines and polyamines. Schrode, J., Folk, J.E. J. Biol. Chem. (1978) [Pubmed]
  6. Induction of lactogenesis in transgenic virgin pigs: evidence for gene and integration site-specific hormonal regulation. Shamay, A., Pursel, V.G., Wall, R.J., Hennighausen, L. Mol. Endocrinol. (1992) [Pubmed]
  7. Neoglycoproteins: in vitro introduction of glycosyl units at glutamines in beta-casein using transglutaminase. Yan, S.B., Wold, F. Biochemistry (1984) [Pubmed]
  8. Structure-activity relationships of cyclic beta-casomorphin-5 analogues. Schmidt, R., Neubert, K., Barth, A., Liebmann, C., Schnittler, M., Chung, N.N., Schiller, P.W. Peptides (1991) [Pubmed]
  9. Molecular cloning and phylogenetic analysis of canine beta-casein. Watanabe, M., Sugano, S., Togashi, T., Imai, J., Uchida, K., Yamaguchi, R., Tateyama, S. DNA Seq. (2000) [Pubmed]
  10. Digestion by pancreatic juice of a beta-casomorphin-containing fragment of buffalo beta-casein. Petrilli, P., Pucci, P., Pelissier, J.P., Addeo, F. Int. J. Pept. Protein Res. (1987) [Pubmed]
  11. Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A. Beninati, S., Nicolini, L., Jakus, J., Passeggio, A., Abbruzzese, A. Biochem. J. (1995) [Pubmed]
  12. Expression of components of the insulin-like growth factor system in pig mammary glands and serum during pregnancy and pseudopregnancy: effects of oestrogen. Lee, C.Y., Bazer, F.W., Simmen, F.A. J. Endocrinol. (1993) [Pubmed]
  13. Global quantitative phosphoprotein analysis using Multiplexed Proteomics technology. Steinberg, T.H., Agnew, B.J., Gee, K.R., Leung, W.Y., Goodman, T., Schulenberg, B., Hendrickson, J., Beechem, J.M., Haugland, R.P., Patton, W.F. Proteomics (2003) [Pubmed]
WikiGenes - Universities